UniProt P03126
Protein E6 (P03126)
Protein E6 (UniProt P03126): 33 experimental structures on GenesisL1, 2 ligands bound, 102 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P03126
- Protein
- Protein E6
- Experimental structures
- 33
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 102 · 11 records with a druggable one
Structures
33 records of P03126 in the MolNFT archive: 33 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FK4 | Solution structure of the C-terminal zinc binding domain of the HPV16 E6 oncoprotein | solution nmr | A | — | — |
| 2FK4 | Solution structure of the C-terminal zinc binding domain of the HPV16 E6 oncoprotein | solution nmr | A | — | — |
| 2KPL | Magi-1 PDZ1 / E6CT | solution nmr | B | — | — |
| 2KPL | Magi-1 PDZ1 / E6CT | solution nmr | B | — | — |
| 2LJX | Structure of the monomeric N-terminal domain of HPV16 E6 oncoprotein | solution nmr | A | — | — |
| 2LJX | Structure of the monomeric N-terminal domain of HPV16 E6 oncoprotein | solution nmr | A | — | — |
| 2LJY | Haddock model structure of the N-terminal domain dimer of HPV16 E6 | solution nmr | A, B | — | — |
| 2LJY | Haddock model structure of the N-terminal domain dimer of HPV16 E6 | solution nmr | A, B | — | — |
| 2LJZ | Structure of the C-terminal domain of HPV16 E6 oncoprotein | solution nmr | A | — | — |
| 2LJZ | Structure of the C-terminal domain of HPV16 E6 oncoprotein | solution nmr | A | — | — |
| 4GIZ | Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide… | x-ray diffraction | C, D | — | — |
| 4GIZ | Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with lxxll peptide… | x-ray diffraction | C, D | — | — |
| 4JOP | CFTR Associated Ligand (CAL) PDZ bound to HPV16 E6 oncoprotein C-terminal peptide (TRRETQL) | x-ray diffraction | C, D | — | — |
| 4JOP | Cftr associated ligand (cal) PDZ bound to HPV16 E6 oncoprotein C- terminal peptide (trretql) | x-ray diffraction | C, D | — | — |
| 4XR8 | Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution | x-ray diffraction | F, H | — | — |
| 4XR8 | Crystal structure of the HPV16 E6/E6AP/P53 ternary complex at 2.25 a resolution | x-ray diffraction | F, H | — | — |
| 6HKS | Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide | x-ray diffraction | G, H, I, J, K, L | — | — |
| 6HKS | Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide | x-ray diffraction | G, H, I, J, K, L | — | — |
| 6SIV | Structure of HPV16 E6 oncoprotein in complex with mutant IRF3 LxxLL motif | x-ray diffraction | B | ZN | 4 (best 0.65) |
| 6SIV | Structure of HPV16 E6 oncoprotein in complex with mutant IRF3 lxxll motif | x-ray diffraction | B | ZN | — |
| 6SJA | Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif | x-ray diffraction | B | ZN | 3 (best 0.60) |
| 6SJA | Structure of HPV16 E6 oncoprotein in complex with IRF3 lxxll motif | x-ray diffraction | B | ZN | — |
| 6TWU | MAGI1_2 complexed with a phosphomimetic 16E6 peptide | x-ray diffraction | C | — | — |
| 6TWU | MAGI1_2 complexed with a phosphomimetic 16E6 peptide | x-ray diffraction | C | — | — |
| 7UAJ | Crystal structure of apo HPV16 E6 | x-ray diffraction | A, B, C, D | GLC, ZN | 19 (best 0.85) |
| 8GCR | HPV16 E6-E6AP-p53 complex | electron microscopy | A | ZN | 6 (best 0.77) |
| 8JRN | Structure of E6AP-E6 complex in Att1 state | electron microscopy | D, B | ZN | 13 (best 0.79) |
| 8JRO | Structure of E6AP-E6 complex in Att2 state | electron microscopy | D, B | ZN | 11 (best 0.81) |
| 8JRP | Structure of E6AP-E6 complex in Att3 state | electron microscopy | B, D | ZN | 11 (best 0.80) |
| 8JRQ | Structure of E6AP-E6 complex in Det1 state | electron microscopy | B, D | ZN | 10 (best 0.79) |
| 8JRR | Structure of E6AP-E6 complex in Det2 state | electron microscopy | B, D | ZN | 11 (best 0.83) |
| 8R1F | Monomeric E6AP-E6-p53 ternary complex | electron microscopy | B | ZN | 6 (best 0.83) |
| 8R1G | Dimeric ternary structure of E6AP-E6-p53 | electron microscopy | B, E | ZN | 8 (best 0.87) |
Ligands
Experiment against prediction
- 7UAJ chain A against the predicted model P0AEX9: TM-score 0.72, RMSD 0.77 Å
- 7UAJ chain D against the predicted model P0AEX9: TM-score 0.72, RMSD 0.73 Å
- 7UAJ chain B against the predicted model P0AEX9: TM-score 0.71, RMSD 0.80 Å
- 7UAJ chain C against the predicted model P0AEX9: TM-score 0.72, RMSD 0.78 Å
- 8R1G chain E against the predicted model Q12306: TM-score 0.23, RMSD 3.38 Å
- 8R1G chain B against the predicted model Q12306: TM-score 0.23, RMSD 3.38 Å
- 8R1F chain B against the predicted model Q12306: TM-score 0.23, RMSD 3.38 Å
Elsewhere
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