UniProt Q96PN6
Adenylate cyclase type 10 (Q96PN6)
Adenylate cyclase type 10 (UniProt Q96PN6), EC 4.6.1.1: 66 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96PN6
- Protein
- Adenylate cyclase type 10
- EC
- 4.6.1.1
- Experimental structures
- 66
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 46 · 8 records with a druggable one
Structures
67 records of Q96PN6 in the MolNFT archive: 66 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4CLF | Crystal structure of human soluble Adenylyl Cyclase (Apo form) | x-ray diffraction | A | — | — |
| 4CLF | Crystal structure of human soluble adenylyl cyclase (apo form) | x-ray diffraction | A | — | — |
| 4CLK | Crystal structure of human soluble Adenylyl Cyclase in complex with… | x-ray diffraction | A | — | — |
| 4CLK | Crystal structure of human soluble adenylyl cyclase in complex with… | x-ray diffraction | A | — | — |
| 4CLL | Crystal structure of human soluble Adenylyl Cyclase in complex with bicarbonate | x-ray diffraction | A | — | — |
| 4CLL | Crystal structure of human soluble adenylyl cyclase in complex with bicarbonate | x-ray diffraction | A | — | — |
| 4CLP | Crystal structure of human soluble Adenylyl Cyclase complex with… | x-ray diffraction | A | — | — |
| 4CLP | Crystal structure of human soluble adenylyl cyclase complex with… | x-ray diffraction | A | — | — |
| 4CLS | Crystal structure of human soluble Adenylyl Cyclase with Pyrophosphate | x-ray diffraction | A | — | — |
| 4CLS | Crystal structure of human soluble adenylyl cyclase with pyrophosphate | x-ray diffraction | A | — | — |
| 4CLT | Crystal structure of human soluble Adenylyl Cyclase with adenosine-3', 5'-cyclic-monophosphate and… | x-ray diffraction | A | — | — |
| 4CLT | Crystal structure of human soluble adenylyl cyclase with adenosine-3', 5'-cyclic-monophosphate and… | x-ray diffraction | A | — | — |
| 4CLU | Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate | x-ray diffraction | A | — | — |
| 4CLU | Crystal structure of human soluble adenylyl cyclase with pyrophosphate | x-ray diffraction | A | — | — |
| 4CLW | Crystal structure of human soluble Adenylyl Cyclase in complex with… | x-ray diffraction | A | — | — |
| 4CLW | Crystal structure of human soluble adenylyl cyclase in complex with… | x-ray diffraction | A | — | — |
| 4CLY | Crystal structure of human soluble Adenylyl Cyclase soaked with biselenite | x-ray diffraction | A | — | — |
| 4CLY | Crystal structure of human soluble adenylyl cyclase soaked with biselenite | x-ray diffraction | A | — | — |
| 4CLZ | Crystal structure of human soluble Adenylyl Cyclase with Inhibitor 4… | x-ray diffraction | A | — | — |
| 4CLZ | Crystal structure of human soluble adenylyl cyclase with inhibitor 4… | x-ray diffraction | A | — | — |
| 4CM0 | Crystal structure of human soluble Adenylyl Cyclase with alpha,beta… | x-ray diffraction | A | — | — |
| 4CM0 | Crystal structure of human soluble adenylyl cyclase with ALPHA,BETA… | x-ray diffraction | A | — | — |
| 4CM2 | Crystal structure of human soluble Adenylyl Cyclase soaked with bisulfite | x-ray diffraction | A | — | — |
| 4CM2 | Crystal structure of human soluble adenylyl cyclase soaked with bisulfite | x-ray diffraction | A | — | — |
| 4OYA | Human solAC Complexed with (4-Aminofurazan-3-yl)-[3-(1H-benzoimidazol-2-ylmethoxy)phenyl]metha | x-ray diffraction | A | — | — |
| 4OYA | Human solac complexed with (4-aminofurazan-3-yl)-[3-(1H-benzoimidazol- 2-YLMETHOXY)PHENYL]METHANONE | x-ray diffraction | A | — | — |
| 4OYB | Crystal Structure Analysis of the solAC | x-ray diffraction | A | — | — |
| 4OYB | Crystal structure analysis of the solac | x-ray diffraction | A | — | — |
| 4OYI | Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-metha | x-ray diffraction | A | — | — |
| 4OYI | Human solac complexed with (4-amino-furazan-3-yl)-phenyl-methanone | x-ray diffraction | A | — | — |
| 4OYM | Human solAC Complexed with (4-Amino-furazan-3-yl)-(3-methoxy-phenyl)-metha | x-ray diffraction | A | — | — |
| 4OYM | Human solac complexed with (4-amino-furazan-3-yl)-(3-methoxy-phenyl)- methanone | x-ray diffraction | A | — | — |
| 4OYO | Human solAC Complexed with 4-(2-Chlorophenyl)-3-methyl-1H-pyrazole | x-ray diffraction | A | — | — |
| 4OYO | Human solac complexed with 4-(2-chlorophenyl)-3-methyl-1H-pyrazole | x-ray diffraction | A | — | — |
| 4OYP | Human solAC Complexed with 1-Benzofuran-2-carboxylic acid | x-ray diffraction | A | — | — |
| 4OYP | Human solac complexed with 1-benzofuran-2-carboxylic acid | x-ray diffraction | A | — | — |
| 4OYW | Crystal Structure of Human Soluble Adenylate Cyclase | x-ray diffraction | A | — | — |
| 4OYW | Crystal structure of human soluble adenylate cyclase | x-ray diffraction | A | — | — |
| 4OYX | Human solAC Complexed with AMPCPP | x-ray diffraction | A | — | — |
| 4OYX | Human solac complexed with ampcpp | x-ray diffraction | A | — | — |
| 4OYZ | Human solAC Complexed with Bicarbonate | x-ray diffraction | A | — | — |
| 4OYZ | Human solac complexed with bicarbonate | x-ray diffraction | A | — | — |
| 4OZ2 | Human solAC Complexed with 4-(4-Fluorophenyl)-3-methyl-1H-pyrazole | x-ray diffraction | A | — | — |
| 4OZ2 | Human solac complexed with 4-(4-fluorophenyl)-3-methyl-1H-pyrazole | x-ray diffraction | A | — | — |
| 4OZ3 | Human solAC Complexed with 4-phenyl-3-(trifluoromethyl)-1H-pyrazole | x-ray diffraction | A | — | — |
| 4OZ3 | Human solac complexed with 4-phenyl-3-(trifluoromethyl)-1H-pyrazole | x-ray diffraction | A | — | — |
| 4UST | Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with… | x-ray diffraction | A | — | — |
| 4UST | Crystal structure of human soluble adenylyl cyclase with pyrophosphate resulting from soaking with… | x-ray diffraction | A | — | — |
| 4USU | Crystal structure of human soluble Adenylyl Cyclase in complex with… | x-ray diffraction | A | — | — |
| 4USU | Crystal structure of human soluble adenylyl cyclase in complex with… | x-ray diffraction | A | — | — |
| 4USV | Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with… | x-ray diffraction | A | — | — |
| 4USV | Crystal structure of human soluble adenylyl cyclase with pyrophosphate resulting from soaking with… | x-ray diffraction | A | — | — |
| 4USW | Crystal structure of human soluble Adenylyl Cyclase with ATP | x-ray diffraction | A | — | — |
| 4USW | Crystal structure of human soluble adenylyl cyclase with ATP | x-ray diffraction | A | — | — |
| 5D0R | Crystal structure of human soluble Adenylyl Cyclase with the inhibitor bithionol | x-ray diffraction | A | B1T | 5 (best 0.76) |
| 5D0R | Crystal structure of human soluble adenylyl cyclase with the inhibitor bithionol | x-ray diffraction | A | — | — |
| 5IV3 | Crystal structure of human soluble adenylyl cyclase in complex with… | x-ray diffraction | A | LRI, APC, CA, CL | 7 (best 0.78) |
| 5IV3 | Crystal structure of human soluble adenylyl cyclase in complex with… | x-ray diffraction | A | — | — |
| 5IV4 | Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor… | x-ray diffraction | A | LRI, CL | 5 (best 0.79) |
| 5IV4 | Crystal structure of the human soluble cyclase in complex with the allosteric inhibitor LRE1 | x-ray diffraction | A | — | — |
7 records more on the page itself.
Ligands
- CL · Chloride ion · in 3 records
- LRI · 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine · in 2 records
- 1S2 · 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine · in 1 record
- APC · Diphosphomethylphosphonic acid adenosyl ester · in 1 record
- B1T · 2,2'-sulfanediylbis(4,6-dichlorophenol) · in 1 record
- CA · Calcium ion · in 1 record
- PJU · [(3~{R})-4-[2-[2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-[bis(fluoranyl)methyl]pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol · in 1 record
- V6U · methyl 2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-methyl-pyrazol-4-yl]methyl]benzoate · in 1 record
- V9E · 4-chloranyl-6-[1-methyl-4-(thiophen-2-ylmethyl)pyrazol-3-yl]pyrimidin-2-amine · in 1 record
- VBB · 2-(dimethylamino)ethyl 5-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-2-methyl-4-(phenylmethyl)pyrazole-3-carboxylate · in 1 record
- VE1 · 4-chloranyl-6-[4-[(3-fluorophenyl)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-amine · in 1 record
Experiment against prediction
- 8CNH chain A against the predicted model Q96PN6: TM-score 0.97, RMSD 1.61 Å
- 7OVD chain A against the predicted model Q96PN6: TM-score 0.96, RMSD 1.62 Å
- 8COJ chain A against the predicted model Q96PN6: TM-score 0.96, RMSD 1.64 Å
- 8COT chain A against the predicted model Q96PN6: TM-score 0.96, RMSD 1.68 Å
- 8CO7 chain A against the predicted model Q96PN6: TM-score 0.96, RMSD 1.71 Å
- 5IV4 chain A against the predicted model Q96PN6: TM-score 0.96, RMSD 1.70 Å
- 5IV4 chain A against the predicted model Q96PN6: TM-score 0.96, RMSD 1.70 Å
- 5D0R chain A against the predicted model Q96PN6: TM-score 0.96, RMSD 1.76 Å
- 5D0R chain A against the predicted model Q96PN6: TM-score 0.96, RMSD 1.76 Å
- 5IV3 chain A against the predicted model Q96PN6: TM-score 0.95, RMSD 1.82 Å
Elsewhere
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