UniProt Q962Y6
Thioredoxin glutathione reductase (Q962Y6)
Thioredoxin glutathione reductase (UniProt Q962Y6), EC 1.6.4.5: 53 experimental structures on GenesisL1, 43 ligands bound, 460 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q962Y6
- Protein
- Thioredoxin glutathione reductase
- EC
- 1.6.4.5
- Experimental structures
- 53
- Predicted models
- 0
- Ligands
- 43
- Pockets
- 460 · 38 records with a druggable one
Structures
53 records of Q962Y6 in the MolNFT archive: 53 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2V6O | Structure of Schistosoma mansoni Thioredoxin-Glutathione Reductase (SmTGR) | x-ray diffraction | A | — | — |
| 2V6O | Structure of schistosoma mansoni thioredoxin-glutathione reductase (smtgr) | x-ray diffraction | A | — | — |
| 2X8C | Thioredoxin glutathione reductase from Schistosoma mansoni with the reduced C-terminal end | x-ray diffraction | A, B | — | — |
| 2X8C | Thioredoxin glutathione reductase from schistosoma mansoni with the reduced C-terminal end | x-ray diffraction | A, B | — | — |
| 2X8G | Oxidized thioredoxin glutathione reductase from Schistosoma mansoni | x-ray diffraction | A | — | — |
| 2X8G | Oxidized thioredoxin glutathione reductase from schistosoma mansoni | x-ray diffraction | A | — | — |
| 2X8H | Thioredoxin glutathione reductase from Schistosoma mansoni in complex with GSH | x-ray diffraction | A | — | — |
| 2X8H | Thioredoxin glutathione reductase from schistosoma mansoni in complex with gsh | x-ray diffraction | A | — | — |
| 2X99 | Thioredoxin glutathione reductase from Schistosoma mansoni in complex with NADPH | x-ray diffraction | A | — | — |
| 2X99 | Thioredoxin glutathione reductase from schistosoma mansoni in complex with NADPH | x-ray diffraction | A | — | — |
| 3H4K | Crystal structure of the wild type Thioredoxin glutatione reductase from Schistosoma mansoni in… | x-ray diffraction | A | — | — |
| 3H4K | Crystal structure of the wild type thioredoxin glutatione reductase from schistosoma mansoni in… | x-ray diffraction | A | — | — |
| 7B02 | Thioredoxin glutathione reductase from Schistosoma mansoni in complex with… | x-ray diffraction | A | FAD, SJN, K, CL, NA | 7 (best 0.82) |
| 7B02 | Thioredoxin glutathione reductase from schistosoma mansoni in complex with… | x-ray diffraction | A | FAD, SJN, K, CL, NA | — |
| 7NPX | Thioredoxin glutathione reductase from Schistosoma mansoni in complex with… | x-ray diffraction | A, B | FAD, EY7, CL, K | 13 (best 0.86) |
| 7NPX | Thioredoxin glutathione reductase from schistosoma mansoni in complex with… | x-ray diffraction | A, B | FAD, EY7, CL, K | — |
| 8A1R | cryo-EM structure of thioredoxin glutathione reductase in complex with a non-competitive inhibitor | electron microscopy | A, B | FAD, KW2 | — |
| 8PDD | Thioredoxin glutathione reductase of Schistosoma mansoni at 1.25A resolution. | x-ray diffraction | A, B | FAD, MG | 14 (best 0.85) |
| 8PL0 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 1. | x-ray diffraction | A, B | FAD, I8G | 13 (best 0.82) |
| 8PL1 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 2. | x-ray diffraction | A, B | FAD, UVS | 13 (best 0.83) |
| 8PL2 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 3. | x-ray diffraction | A, B | FAD, ZMT | 11 (best 0.85) |
| 8PL3 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 4. | x-ray diffraction | A, B | FAD, ZMI | 14 (best 0.83) |
| 8PL4 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 5. | x-ray diffraction | A, B | FAD, ZMC | 13 (best 0.85) |
| 8PL5 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 6. | x-ray diffraction | A, B | FAD, ZM8 | 13 (best 0.85) |
| 8PL6 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 7. | x-ray diffraction | A | FAD, ZLX | 6 (best 0.79) |
| 8PL7 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 8. | x-ray diffraction | A, B | FAD, ZLT | 15 (best 0.82) |
| 8PL8 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 9. | x-ray diffraction | A | FAD, ZLO | 6 (best 0.82) |
| 8PL9 | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 10. | x-ray diffraction | A, B | FAD, O3D | 14 (best 0.85) |
| 8PLA | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 11. | x-ray diffraction | A, B | FAD, ZLI | 11 (best 0.85) |
| 8PLB | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 12. | x-ray diffraction | A, B | FAD, VWY | 13 (best 0.85) |
| 8PLC | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 13. | x-ray diffraction | A, B | FAD, A7N | 16 (best 0.82) |
| 8PLD | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 14. | x-ray diffraction | A, B | FAD, T9Q | 13 (best 0.83) |
| 8PLE | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 15. | x-ray diffraction | A, B | FAD, VZS | 15 (best 0.82) |
| 8PLF | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 16. | x-ray diffraction | A, B | FAD, NZ1 | 12 (best 0.83) |
| 8PLG | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 17. | x-ray diffraction | A | FAD, YI6 | 8 (best 0.82) |
| 8PLH | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 18. | x-ray diffraction | A | FAD, GVY | 6 (best 0.82) |
| 8PLI | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 19. | x-ray diffraction | A, B | FAD, WZY | 15 (best 0.82) |
| 8PLJ | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 20. | x-ray diffraction | A, B | FAD, ZP8 | 14 (best 0.82) |
| 8PLK | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 21. | x-ray diffraction | A, B | FAD, JO1 | 15 (best 0.82) |
| 8PLL | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 22. | x-ray diffraction | A | FAD, AYV | 7 (best 0.82) |
| 8PLM | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 23. | x-ray diffraction | A | FAD, JJ7 | 7 (best 0.83) |
| 8PLN | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 24. | x-ray diffraction | A | FAD, ZPI | 7 (best 0.82) |
| 8PLO | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 25. | x-ray diffraction | A, B | FAD, WLY | 13 (best 0.83) |
| 8PLP | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 26. | x-ray diffraction | A, B | FAD, WO1 | 14 (best 0.82) |
| 8PLQ | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 27. | x-ray diffraction | A, B | FAD, TEK | 13 (best 0.82) |
| 8PLR | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 28. | x-ray diffraction | A, B | FAD, MJ4 | 11 (best 0.85) |
| 8PLS | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 29. | x-ray diffraction | A, B | FAD, B0M | 14 (best 0.83) |
| 8PLT | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 30. | x-ray diffraction | A, B | FAD, NVD | 13 (best 0.82) |
| 8PLU | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 31. | x-ray diffraction | A, B | FAD, ZPU | 13 (best 0.82) |
| 8PLV | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 32. | x-ray diffraction | A, B | FAD, UXG | 16 (best 0.85) |
| 8PLW | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 33. | x-ray diffraction | A, B | FAD, Q4L | 15 (best 0.82) |
| 8PLX | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 34. | x-ray diffraction | A, B | FAD, O1M | 14 (best 0.82) |
| 8PLY | Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 35. | x-ray diffraction | A, B | FAD, JKG | 13 (best 0.85) |
Ligands
- FAD · Flavin-adenine dinucleotide · in 41 records
- CL · Chloride ion · in 4 records
- K · Potassium ion · in 4 records
- EY7 · 3-(3-methoxyquinoxalin-2-yl)propanoic acid · in 2 records
- NA · Sodium ion · in 2 records
- SJN · 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid · in 2 records
- A7N · (1~{R})-1-(4-ethoxyphenyl)ethanamine · in 1 record
- AYV · 1-[2-methyl-1,3-bis(oxidanyl)propan-2-yl]-3-phenyl-urea · in 1 record
- B0M · 1~{H}-indol-6-yl-(4-methylpiperazin-1-yl)methanone · in 1 record
- GVY · 4-(5-amino-1,3,4-thiadiazol-2-yl)phenol · in 1 record
- I8G · 2-(4-fluorophenoxy)-1-(pyrrolidin-1-yl)ethan-1-one · in 1 record
- JJ7 · 1-{4-[(2-methoxyethyl)amino]piperidin-1-yl}ethan-1-one · in 1 record
- JKG · 4-({[(thiophen-2-yl)methyl]amino}methyl)phenol · in 1 record
- JO1 · 1-methyl-N-[(thiophen-2-yl)methyl]-1H-pyrazole-5-carboxamide · in 1 record
- KW2 · (2~{R},3~{R},4~{S},5~{R})-2-[3-[[[(1~{R},2~{R},3~{R},5~{S})-2,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]amino]methyl]indol-1-yl]oxane-3,4,5-triol · in 1 record
- MG · Magnesium ion · in 1 record
- MJ4 · (2R)-1-{[(5-methylthiophen-2-yl)methyl]amino}propan-2-ol · in 1 record
- NVD · N-{[4-(dimethylamino)phenyl]methyl}-4H-1,2,4-triazol-4-amine · in 1 record
- NZ1 · 5-methoxy-1,3-benzothiazol-2-amine · in 1 record
- O1M · 4-(4-fluorophenyl)piperazine-1-carboxamide · in 1 record
- O3D · 4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione · in 1 record
- Q4L · methyl 4-(4-fluorophenyl)piperazine-1-carboxylate · in 1 record
- T9Q · N-Benzyl-2-methoxyacetamide · in 1 record
- TEK · ~{N}-(1-ethylbenzimidazol-2-yl)ethanamide · in 1 record
- UVS · 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine · in 1 record
- UXG · 1-(diphenylmethyl)azetidin-3-ol · in 1 record
- VWY · N-ethyl-4-[(methylsulfonyl)amino]benzamide · in 1 record
- VZS · N-(2-methoxy-5-methylphenyl)-N'-4H-1,2,4-triazol-4-ylurea · in 1 record
- WLY · 2-(4-methylphenyl)-N-{[(2S)-oxolan-2-yl]methyl}acetamide · in 1 record
- WO1 · (3R)-1-methylpiperidin-3-yl furan-2-carboxylate · in 1 record
Elsewhere
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