UniProt Q92643
GPI-anchor transamidase,GFP-like fluorescent chromoprotein cFP484 (Q92643)
GPI-anchor transamidase,GFP-like fluorescent chromoprotein cFP484 (UniProt Q92643), EC 3.-.-.-: 3 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 7 pockets. Binding sites, druggability and experiment…
- UniProt
- Q92643
- Protein
- GPI-anchor transamidase,GFP-like fluorescent chromoprotein cFP484
- EC
- 3.-.-.-
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 7 · 1 record with a druggable one
Structures
4 records of Q92643 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7W72 | Structure of a human glycosylphosphatidylinositol (gpi) transamidase | electron microscopy | K | CA | — |
| 7WLD | Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53 ångström… | electron microscopy | K | CA, P5S, CLR | — |
| 8IMY | Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate | electron microscopy | K | 05E, CA, 6OU, Y01 | 7 (best 0.86) |
| Q92643 | AlphaFold monomer V2.0 prediction for gpi-anchor transamidase (Q92643) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 3 records
- 05E · 2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate · in 1 record
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 1 record
- CLR · Cholesterol · in 1 record
- P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 8IMY chain K against the predicted model Q92643: TM-score 0.82, RMSD 1.34 Å
- 7W72 chain K against the predicted model Q92643: TM-score 0.81, RMSD 1.72 Å
- 7WLD chain K against the predicted model Q92643: TM-score 0.81, RMSD 1.79 Å
- 8IMY chain K against the predicted model Q9U6Y3: TM-score 0.24, RMSD 6.54 Å
Elsewhere
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