UniProt Q8ZNT7
D-Cysteine desulfhydrase (Q8ZNT7)
D-Cysteine desulfhydrase (UniProt Q8ZNT7), EC 4.4.1.15: 22 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 176 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8ZNT7
- Protein
- D-Cysteine desulfhydrase
- EC
- 4.4.1.15
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 176 · 11 records with a druggable one
Structures
23 records of Q8ZNT7 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4D8T | Crystal structure of D-Cysteine desulfhydrase from Salmonella typhimurium at 2.2 A resolution | x-ray diffraction | A, B, C, D | SO4, CL, BEN | 18 (best 0.86) |
| 4D8T | Crystal structure of D-cysteine desulfhydrase from salmonella typhimurium at 2.2 a resolution | x-ray diffraction | A, B, C, D | — | — |
| 4D8U | Crystal structure of D-Cysteine desulfhydrase from Salmonella typhimurium at 3.3 A in monoclinic… | x-ray diffraction | A, B, C, D, E, F, G, H | PO4 | 20 (best 0.79) |
| 4D8U | Crystal structure of D-cysteine desulfhydrase from salmonella typhimurium at 3.3 a in monoclinic… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4D8W | Salmonella typhimurium D-Cysteine desulfhydrase soaked with D-cys shows pyruvate bound 4 A away… | x-ray diffraction | A, B, C, D | CL, BEN, PYR, SO4 | 15 (best 0.86) |
| 4D8W | Salmonella typhimurium D-cysteine desulfhydrase soaked with D-cys shows pyruvate bound 4 a away… | x-ray diffraction | A, B, C, D | — | — |
| 4D92 | Salmonella typhimurium D-Cysteine desulfhydrase soaked with beta-chloro-D-alanine shows pyruvate… | x-ray diffraction | A, B, C, D | BEN, PYR, SO4 | 16 (best 0.85) |
| 4D92 | Salmonella typhimurium D-cysteine desulfhydrase soaked with beta- chloro-D-alanine shows pyruvate… | x-ray diffraction | A, B, C, D | — | — |
| 4D96 | D-Cysteine desulfhydrase from Salmonella typhimurium complexed with 1-amino-1-carboxycyclopropane… | x-ray diffraction | A, B, C, D | 5PA, BEN, SO4 | 19 (best 0.85) |
| 4D96 | D-cysteine desulfhydrase from salmonella typhimurium complexed with 1- amino-1-carboxycyclopropane… | x-ray diffraction | A, B, C, D | — | — |
| 4D97 | Salmonella typhimurium D-Cysteine desulfhydrase with D-ser bound at active site | x-ray diffraction | A, B, C, D | BEN, DSN | 14 (best 0.85) |
| 4D97 | Salmonella typhimurium D-cysteine desulfhydrase with D-ser bound at active site | x-ray diffraction | A, B, C, D | — | — |
| 4D99 | Salmonella typhimurium D-Cysteine desulfhydrase with L-ser bound non-covalently at the active site | x-ray diffraction | A, B, C, D | BEN, SER, NA | 17 (best 0.85) |
| 4D99 | Salmonella typhimurium D-cysteine desulfhydrase with L-ser bound non- covalently at the active site | x-ray diffraction | A, B, C, D | — | — |
| 4D9B | Pyridoxamine 5' phosphate (PMP) bound form of Salmonella typhimurium D-Cysteine desulfhydrase… | x-ray diffraction | A, B, C, D | BEN, PMP | 14 (best 0.86) |
| 4D9B | Pyridoxamine 5' phosphate (pmp) bound form of salmonella typhimurium D-cysteine desulfhydrase… | x-ray diffraction | A, B, C, D | — | — |
| 4D9C | PMP bound form of Salmonella typhimurium D-Cysteine desulfhydrase obtained after co-crystallization… | x-ray diffraction | A, B, C, D | BEN, PMP | 12 (best 0.85) |
| 4D9C | Pmp bound form of salmonella typhimurium D-cysteine desulfhydrase obtained after co-crystallization… | x-ray diffraction | A, B, C, D | — | — |
| 4D9E | D-Cysteine desulfhydrase from Salmonella typhimurium complexed with L-cycloserine (LCS) | x-ray diffraction | A, B, C, D | BEN, LCS | 14 (best 0.85) |
| 4D9E | D-cysteine desulfhydrase from salmonella typhimurium complexed with L- cycloserine (lcs) | x-ray diffraction | A, B, C, D | — | — |
| 4D9F | D-Cysteine desulfhydrase from Salmonella typhimurium complexed with D-cycloserine (DCS) | x-ray diffraction | A, B, C, D | BEN, DCS | 17 (best 0.80) |
| 4D9F | D-cysteine desulfhydrase from salmonella typhimurium complexed with D- cycloserine (dcs) | x-ray diffraction | A, B, C, D | — | — |
| Q8ZNT7 | AlphaFold monomer V2.0 prediction for D-cysteine desulfhydrase (Q8ZNT7) | predicted | A | — | — |
Ligands
- BEN · Benzamidine · in 10 records
- SO4 · Sulfate ion · in 4 records
- CL · Chloride ion · in 2 records
- PMP · 4'-deoxy-4'-aminopyridoxal-5'-phosphate · in 2 records
- PYR · Pyruvic acid · in 2 records
- 5PA · N-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-Y-lmethyl]-1-amino-cyclopropanecarboxylic acid · in 1 record
- DCS · D-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-N,O-cycloserylamide · in 1 record
- DSN · D-serine · in 1 record
- LCS · [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate · in 1 record
- NA · Sodium ion · in 1 record
- PO4 · Phosphate ion · in 1 record
- SER · Serine · in 1 record
Experiment against prediction
- 4D8U chain A against the predicted model Q8ZNT7: TM-score 0.99, RMSD 0.26 Å
- 4D8U chain A against the predicted model Q8ZNT7: TM-score 0.99, RMSD 0.26 Å
- 4D97 chain A against the predicted model Q8ZNT7: TM-score 1.00, RMSD 0.28 Å
- 4D97 chain A against the predicted model Q8ZNT7: TM-score 1.00, RMSD 0.28 Å
- 4D99 chain A against the predicted model Q8ZNT7: TM-score 1.00, RMSD 0.28 Å
- 4D99 chain A against the predicted model Q8ZNT7: TM-score 1.00, RMSD 0.28 Å
- 4D8U chain E against the predicted model Q8ZNT7: TM-score 0.99, RMSD 0.28 Å
- 4D8U chain E against the predicted model Q8ZNT7: TM-score 0.99, RMSD 0.28 Å
- 4D8W chain A against the predicted model Q8ZNT7: TM-score 1.00, RMSD 0.29 Å
- 4D8W chain A against the predicted model Q8ZNT7: TM-score 1.00, RMSD 0.29 Å
Elsewhere
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