UniProt Q8TDU6
G-protein coupled bile acid receptor 1 (Q8TDU6)
G-protein coupled bile acid receptor 1 (UniProt Q8TDU6): 7 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8TDU6
- Protein
- G-protein coupled bile acid receptor 1
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 18 · 4 records with a druggable one
Structures
8 records of Q8TDU6 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7BW0 | Active human TGR5 complex with a synthetic agonist 23H | electron microscopy | R | — | — |
| 7CFM | Cryo-EM structure of the P395-bound GPBAR-Gs complex | electron microscopy | R | FWX, CLR | 4 (best 0.83) |
| 7CFM | Cryo-EM structure of the P395-bound gpbar-gs complex | electron microscopy | R | FWX, CLR | — |
| 7CFN | Cryo-EM structure of the INT-777-bound GPBAR-Gs complex | electron microscopy | R | FX0, CLR, PLM | 6 (best 0.79) |
| 7CFN | Cryo-EM structure of the int-777-bound gpbar-gs complex | electron microscopy | R | FX0, CLR, PLM | — |
| 7XTQ | Cryo-EM structure of the R399-bound GPBAR-Gs complex | electron microscopy | R | H8I | 5 (best 0.86) |
| 7XTQ | Cryo-EM structure of the R399-bound gpbar-gs complex | electron microscopy | R | H8I | — |
| Q8TDU6 | AlphaFold monomer V2.0 prediction for G-protein coupled bile acid receptor 1 (Q8TDU6) | predicted | A | — | 3 (best 0.80) |
Ligands
- CLR · Cholesterol · in 4 records
- FWX · 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7, 8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide · in 2 records
- FX0 · (2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6, 7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid · in 2 records
- H8I · [2-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone · in 2 records
- PLM · Palmitic acid · in 2 records
Experiment against prediction
- 7CFN chain R against the predicted model Q8TDU6: TM-score 0.95, RMSD 1.45 Å
- 7CFN chain R against the predicted model Q8TDU6: TM-score 0.95, RMSD 1.45 Å
- 7XTQ chain R against the predicted model Q8TDU6: TM-score 0.95, RMSD 1.51 Å
- 7XTQ chain R against the predicted model Q8TDU6: TM-score 0.95, RMSD 1.51 Å
- 7CFM chain R against the predicted model Q8TDU6: TM-score 0.95, RMSD 1.52 Å
- 7CFM chain R against the predicted model Q8TDU6: TM-score 0.95, RMSD 1.52 Å
- 7BW0 chain R against the predicted model Q8TDU6: TM-score 0.93, RMSD 1.82 Å
- 7BW0 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.28 Å
Elsewhere
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