UniProt Q8NHZ8
Anaphase-promoting complex subunit CDC26 (Q8NHZ8)
Anaphase-promoting complex subunit CDC26 (UniProt Q8NHZ8): 34 experimental structures and 1 predicted model on GenesisL1, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8NHZ8
- Protein
- Anaphase-promoting complex subunit CDC26
- Experimental structures
- 34
- Predicted models
- 1
- Pockets
- 20 · 10 records with a druggable one
Structures
35 records of Q8NHZ8 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3HYM | Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure | x-ray diffraction | A, C, E, G, I, K | — | — |
| 3HYM | Insights into anaphase promoting complex tpr subdomain assembly from a CDC26-APC6 structure | x-ray diffraction | A, C, E, G, I, K | — | — |
| 4UI9 | Atomic structure of the human Anaphase-Promoting Complex | electron microscopy | G, W | — | 2 (best 0.81) |
| 4UI9 | Atomic structure of the human anaphase-promoting complex | electron microscopy | G, W | — | — |
| 5A31 | Structure of the human apc-CDH1-HSL1-UBCH10 complex. | electron microscopy | G, W | — | — |
| 5G04 | Structure of the human APC-Cdc20-Hsl1 complex | electron microscopy | G, W | — | — |
| 5G04 | Structure of the human apc-CDC20-HSL1 complex | electron microscopy | G, W | — | — |
| 5G05 | Cryo-EM structure of combined apo phosphorylated APC | electron microscopy | G, W | — | — |
| 5G05 | Cryo-EM structure of combined apo phosphorylated apc | electron microscopy | G, W | — | — |
| 5KHR | Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with… | electron microscopy | G, W | — | — |
| 5KHR | Model of human anaphase-promoting COMPLEX/CYCLOSOME complex (APC15 deletion mutant) in complex with… | electron microscopy | G, W | — | — |
| 5KHU | Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the… | electron microscopy | G, W | — | — |
| 5KHU | Model of human anaphase-promoting COMPLEX/CYCLOSOME (APC15 deletion mutant), in complex with the… | electron microscopy | G, W | — | — |
| 5L9T | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for… | electron microscopy | G, W | — | — |
| 5L9T | Model of human anaphase-promoting COMPLEX/CYCLOSOME (APC/C-CDH1) with E2 UBE2S poised for… | electron microscopy | G, W | — | — |
| 5L9U | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin… | electron microscopy | G, W | — | — |
| 5L9U | Model of human anaphase-promoting COMPLEX/CYCLOSOME (APC/C-CDH1) with a cross linked ubiquitin… | electron microscopy | G, W | — | — |
| 5LCW | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic… | electron microscopy | G, W | — | 2 (best 0.81) |
| 5LCW | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the mitotic… | electron microscopy | G, W | — | — |
| 6Q6G | Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class | electron microscopy | G, W | — | 3 (best 0.80) |
| 6Q6G | Cryo-EM structure of the APC/C-CDC20-CDK2-CYCLINA2-CKS2 complex, the D1 box class | electron microscopy | G, W | — | — |
| 6Q6H | Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class | electron microscopy | G, W | — | 2 (best 0.80) |
| 6Q6H | Cryo-EM structure of the APC/C-CDC20-CDK2-CYCLINA2-CKS2 complex, the D2 box class | electron microscopy | G, W | — | — |
| 6TLJ | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic… | electron microscopy | G, W | — | 2 (best 0.81) |
| 6TLJ | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the mitotic… | electron microscopy | G, W | — | — |
| 6TM5 | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate… | electron microscopy | G, W | — | 2 (best 0.83) |
| 6TM5 | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the NEK2A substrate… | electron microscopy | G, W | — | — |
| 6TNT | SUMOylated apoAPC/C with repositioned APC2 WHB domain | electron microscopy | G, W | — | 2 (best 0.81) |
| 6TNT | Sumoylated APOAPC/C with repositioned APC2 whb domain | electron microscopy | G, W | — | — |
| 7QE7 | High-resolution structure of the anaphase-promoting COMPLEX/CYCLOSOME (APC/C) bound to co-activator… | electron microscopy | G, W | — | — |
| 8PKP | Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution | electron microscopy | G, W | — | 2 (best 0.80) |
| 8TAR | APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD | electron microscopy | G, W | — | — |
| 8TAU | APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB | electron microscopy | G, W | — | 1 (best 0.67) |
| 9GAW | High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator… | electron microscopy | G, W | — | 2 (best 0.81) |
| Q8NHZ8 | AlphaFold monomer V2.0 prediction for anaphase-promoting complex subunit CDC26 (Q8NHZ8) | predicted | A | — | — |
Experiment against prediction
- 9GAW chain W against the predicted model Q8NHZ8: TM-score 0.45, RMSD 2.21 Å
- 8TAR chain G against the predicted model Q8NHZ8: TM-score 0.45, RMSD 2.71 Å
- 9GAW chain G against the predicted model Q8NHZ8: TM-score 0.44, RMSD 2.47 Å
- 3HYM chain E against the predicted model Q8NHZ8: TM-score 0.44, RMSD 2.64 Å
- 3HYM chain E against the predicted model Q8NHZ8: TM-score 0.44, RMSD 2.64 Å
- 7QE7 chain G against the predicted model Q8NHZ8: TM-score 0.43, RMSD 2.17 Å
- 8TAU chain G against the predicted model Q8NHZ8: TM-score 0.42, RMSD 2.43 Å
- 8PKP chain W against the predicted model Q8NHZ8: TM-score 0.42, RMSD 2.29 Å
- 7QE7 chain W against the predicted model Q8NHZ8: TM-score 0.41, RMSD 2.18 Å
- 8TAR chain W against the predicted model Q8NHZ8: TM-score 0.41, RMSD 2.19 Å
Elsewhere
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