UniProt Q8N5Z0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Q8N5Z0)
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (UniProt Q8N5Z0), EC 2.6.1.39, 2.6.1.7: 34 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 31 pockets. Binding sites, druggability and…
- UniProt
- Q8N5Z0
- Protein
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- EC
- 2.6.1.39, 2.6.1.7
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 31 · 3 records with a druggable one
Structures
35 records of Q8N5Z0 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QLR | Crystal structure of human kynurenine aminotransferase II | x-ray diffraction | A, B, C, D | — | — |
| 2QLR | Crystal structure of human kynurenine aminotransferase II | x-ray diffraction | A, B, C, D | — | — |
| 2R2N | The crystal structure of human kynurenine aminotransferase II in complex with kynurenine | x-ray diffraction | A, B, C, D | — | — |
| 2R2N | The crystal structure of human kynurenine aminotransferase II in complex with kynurenine | x-ray diffraction | A, B, C, D | — | — |
| 2VGZ | Crystal structure of human kynurenine aminotransferase II | x-ray diffraction | A, B | — | — |
| 2VGZ | Crystal structure of human kynurenine aminotransferase II | x-ray diffraction | A, B | — | — |
| 2XH1 | Crystal structure of human KAT II-inhibitor complex | x-ray diffraction | A, B | — | — |
| 2XH1 | Crystal structure of human kat II-inhibitor complex | x-ray diffraction | A, B | — | — |
| 3DC1 | Crystal structure of kynurenine aminotransferase II complex with alpha-ketoglutarate | x-ray diffraction | A, B, C, D | — | — |
| 3DC1 | Crystal structure of kynurenine aminotransferase II complex with alpha-ketoglutarate | x-ray diffraction | A, B, C, D | — | — |
| 3UE8 | Kynurenine Aminotransferase II Inhibitors | x-ray diffraction | A, B | — | — |
| 3UE8 | Kynurenine aminotransferase II inhibitors | x-ray diffraction | A, B | — | — |
| 4GDY | Kynurenine Aminotransferase II inhibitors | x-ray diffraction | A, B | — | — |
| 4GDY | Kynurenine aminotransferase II inhibitors | x-ray diffraction | A, B | — | — |
| 4GE4 | Kynurenine Aminotransferase II Inhibitors | x-ray diffraction | A, B | — | — |
| 4GE4 | Kynurenine aminotransferase II inhibitors | x-ray diffraction | A, B | — | — |
| 4GE7 | Kynurenine Aminotransferase II Inhibitors | x-ray diffraction | A, B | — | — |
| 4GE7 | Kynurenine aminotransferase II inhibitors | x-ray diffraction | A, B | — | — |
| 4GE9 | Kynurenine Aminotransferase II Inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4GE9 | Kynurenine aminotransferase II inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4GEB | Kynurenine Aminotransferase II Inhibitors | x-ray diffraction | A, B | — | — |
| 4GEB | Kynurenine aminotransferase II inhibitors | x-ray diffraction | A, B | — | — |
| 5EFS | The crystal structure of human kynurenine aminotransferase II | x-ray diffraction | A | — | 5 (best 0.50) |
| 5EFS | The crystal structure of human kynurenine aminotransferase II | x-ray diffraction | A | — | — |
| 5EUN | The Crystal Structure of Human Kynurenine Aminotransferase II, PLP-bound form, at 1.83 A | x-ray diffraction | A | — | — |
| 5EUN | The crystal structure of human kynurenine aminotransferase II, plp- bound form, at 1.83 a | x-ray diffraction | A | — | — |
| 5TF5 | Crystal structure of human kat-2 in complex with a reversible inhibitor | x-ray diffraction | A, B | 7AR | 7 (best 0.67) |
| 5TF5 | Crystal structure of human kat-2 in complex with a reversible inhibitor | x-ray diffraction | A, B | 7AR | — |
| 6D0A | Crystal structure of Kynurenine Aminotransferase-II in apo-form, at 1.47 A resolution | x-ray diffraction | A | — | 5 (best 0.45) |
| 6D0A | Crystal structure of kynurenine aminotransferase-II in apo-form, at 1.47 a resolution | x-ray diffraction | A | — | — |
| 6T8P | HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4… | x-ray diffraction | A, B | MVT, IOD | 10 (best 0.72) |
| 6T8P | Hkatii in complex with ligand (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)… | x-ray diffraction | A, B | MVT, IOD | — |
| 6T8Q | HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4… | x-ray diffraction | A | MVQ, CD, CL | 4 (best 0.46) |
| 6T8Q | Hkatii in complex with ligand (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)… | x-ray diffraction | A | MVQ, CD, CL | — |
| Q8N5Z0 | AlphaFold monomer V2.0 prediction for KYNURENINE/ALPHA-aminoadipate aminotransferase, mitochondrial… | predicted | A | — | — |
Ligands
- 7AR · (2R)-2-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid · in 2 records
- CD · Cadmium ion · in 2 records
- CL · Chloride ion · in 2 records
- IOD · Iodide ion · in 2 records
- MVQ · (2~{R})-1-[6-methyl-5-(oxan-4-yl)-7-oxidanylidene-[1, 3]thiazolo[5,4-d]pyrimidin-2-yl]-~{N}-(phenylmethyl) pyrrolidine-2-carboxamide · in 2 records
- MVT · 3,5-bis(fluoranyl)-~{N}-[5-[(2~{R})-2-(3-fluorophenyl)-3-methyl-butyl]-1,3,4-thiadiazol-2-yl]benzenesulfonamide · in 2 records
Experiment against prediction
- 2XH1 chain A against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.64 Å
- 2XH1 chain A against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.64 Å
- 3DC1 chain A against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.82 Å
- 3DC1 chain A against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.82 Å
- 2XH1 chain B against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.67 Å
- 2XH1 chain B against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.67 Å
- 3UE8 chain B against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.77 Å
- 3UE8 chain B against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.77 Å
- 3DC1 chain B against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.99 Å
- 3DC1 chain B against the predicted model Q8N5Z0: TM-score 0.99, RMSD 0.99 Å
Elsewhere
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