MolNFT v1 · #118197 · protein

The crystal structure of human kynurenine aminotransferase II, plp- bound form, at 1.83 a

5EUN · KYNURENINE/ALPHA-aminoadipate aminotransferase…: “The crystal structure of human kynurenine aminotransferase II, plp- bound form, at 1.83 a”. X-ray diffraction, 4 pockets (best druggability 0.41). MolNFT v1 #118197 on GenesisL1: 3D…

PDB: 5EUN
Type: protein
Length: 425 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: KYNURENINE/ALPHA-aminoadipate aminotransferase, mitochondrial
EC: 2.6.1.39, 2.6.1.7
UniProt: Q8N5Z0
Pockets: 4 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	KYNURENINE/ALPHA-aminoadipate aminotransferase, mitochondrial (EC 2.6.1.39, 2.6.1.7)	protein	425	42% helix, 15% strand	Q8N5Z0

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.41	0.80	24	empty
2	124	0.37	0.73	21	empty
3	67	0.36	0.77	16	empty
4	64	0.36	0.77	15	empty

Modifications

Observed in the structure: 1 modified (cofactor).

Compared structures

5EUN · The Crystal Structure of Human Kynurenine Aminotransferase II, PLP-bound form, at 1.83 A · the same entry in another collection · chain A against A, TM-score 1.00
Q8N5Z0 · AlphaFold monomer V2.0 prediction for KYNURENINE/ALPHA-aminoadipate aminotransferase… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8N5Z0
Elsewhere: RCSB PDB 5EUN · PDBe 5EUN · UniProt Q8N5Z0

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