MolNFT v1 · #51761 · protein
Crystal structure of human kynurenine aminotransferase II
2VGZ · KYNURENINE/ALPHA-aminoadipate aminotransferase: “Crystal structure of human kynurenine aminotransferase II”. X-ray diffraction, 2 ligands (PLP, IOD), 5 pockets (best druggability 0.67). MolNFT v1 #51761 on GenesisL1: 3D structure…
- PDB
- 2VGZ
- Type
- protein
- Length
- 828 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- KYNURENINE/ALPHA-aminoadipate aminotransferase
- EC
- 2.6.1.39, 2.6.1.7
- UniProt
- Q8N5Z0
- Ligands
- PLP, IOD
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | KYNURENINE/ALPHA-aminoadipate aminotransferase (EC 2.6.1.39, 2.6.1.7) | protein | 414 | 41% helix, 18% strand | Q8N5Z0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 307 | 0.67 | 0.82 | 39 | PLP |
| 2 | 313 | 0.64 | 0.80 | 41 | PLP |
| 3 | 295 | 0.64 | 0.81 | 29 | empty |
| 4 | 72 | 0.44 | 0.82 | 23 | empty |
| 5 | 81 | 0.44 | 0.80 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 3789 Ų buried · 58 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 2VGZ · Crystal structure of human kynurenine aminotransferase II · the same entry in another collection · chain A against A, TM-score 1.00
- Q8N5Z0 · AlphaFold monomer V2.0 prediction for KYNURENINE/ALPHA-aminoadipate aminotransferase… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N5Z0
- Elsewhere: RCSB PDB 2VGZ · PDBe 2VGZ · UniProt Q8N5Z0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.