UniProt Q8N371
JmjC domain-containing protein 5 (Q8N371)
JmjC domain-containing protein 5 (UniProt Q8N371), EC 1.14.11.27, 1.14.11.47: 42 experimental structures on GenesisL1, 13 ligands bound, 5 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8N371
- Protein
- JmjC domain-containing protein 5
- EC
- 1.14.11.27, 1.14.11.47, 3.4.-.-
- Experimental structures
- 42
- Predicted models
- 0
- Ligands
- 13
- Pockets
- 5 · 2 records with a druggable one
Structures
42 records of Q8N371 in the MolNFT archive: 42 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3UYJ | Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG | x-ray diffraction | A, B | — | — |
| 3UYJ | Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-kg | x-ray diffraction | A, B | — | — |
| 4AAP | Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with… | x-ray diffraction | A, B | — | — |
| 4AAP | Crystal structure of JMJD5 domain of human lysine-specific demethylase 8 (KDM8) in complex with… | x-ray diffraction | A, B | — | — |
| 4GAZ | Crystal Structure of a Jumonji Domain-containing Protein JMJD5 | x-ray diffraction | A, B | — | — |
| 4GAZ | Crystal structure of a jumonji domain-containing protein JMJD5 | x-ray diffraction | A, B | — | — |
| 4GJY | JMJD5 in complex with N-Oxalylglycine | x-ray diffraction | A | — | — |
| 4GJY | JMJD5 in complex with N-oxalylglycine | x-ray diffraction | A | — | — |
| 4GJZ | JMJD5 in complex with 2-oxoglutarate | x-ray diffraction | A | — | — |
| 4GJZ | JMJD5 in complex with 2-oxoglutarate | x-ray diffraction | A | — | — |
| 4QU1 | Crystal structure of human JMJD5 jmj-c domain | x-ray diffraction | A | — | — |
| 4QU1 | Crystal structure of human JMJD5 jmj-C domain | x-ray diffraction | A | — | — |
| 5FBJ | Complex structure of JMJD5 and substrate | x-ray diffraction | A | AKG, ZN | — |
| 5FBJ | Complex structure of JMJD5 and substrate | x-ray diffraction | A | — | — |
| 6AVS | Complex structure of JMJD5 and symmetric monomethyl-arginine (mma) | x-ray diffraction | A | ZN | — |
| 6AX3 | Complex structure of JMJD5 and Symmetric Dimethyl-Arginine (SDMA) | x-ray diffraction | A | 2MR, AKG, ZN | 1 (best 0.59) |
| 6AX3 | Complex structure of JMJD5 and symmetric dimethyl-arginine (sdma) | x-ray diffraction | A | AKG, ZN | — |
| 6F4M | Human JMJD5 in its apo form. | x-ray diffraction | A | — | — |
| 6F4N | Human JMJD5 in complex with MN and 2OG. | x-ray diffraction | A, B | MN, AKG | 3 (best 0.45) |
| 6F4N | Human JMJD5 in complex with mn and 2OG. | x-ray diffraction | A, B | MN, AKG | — |
| 6F4O | Human JMJD5 in complex with Mn(II) and Succinate. | x-ray diffraction | A | MN | — |
| 6F4O | Human JMJD5 in complex with MN(II) and succinate. | x-ray diffraction | A | MN | — |
| 6F4P | Human JMJD5 in complex with mn, nog and RPS6 (129-144) (complex-1) | x-ray diffraction | A | MN, OGA | — |
| 6F4Q | Human JMJD5 (Q275C) in complex with MN(II), nog and RPS6-A138C (129- 144) (complex-2) | x-ray diffraction | A | MN, OGA | — |
| 6F4R | Human JMJD5 (N308C) in complex with Mn(II), NOG and RCCD1 (139-143) (complex-3) | x-ray diffraction | A | MN, OGA | — |
| 6F4R | Human JMJD5 (N308C) in complex with MN(II), nog and RCCD1 (139-143) (complex-3) | x-ray diffraction | A | MN, OGA | — |
| 6F4S | Human JMJD5 (N308C) in complex with Mn(II), 2OG and RCCD1 (139-143) (complex-4) | x-ray diffraction | A | MN, AKG | — |
| 6F4S | Human JMJD5 (N308C) in complex with MN(II), 2OG and RCCD1 (139-143) (complex-4) | x-ray diffraction | A | MN, AKG | — |
| 6F4T | Human JMJD5 (W414C) in complex with MN(II), nog and RCCD1 (139-143) (complex-5) | x-ray diffraction | A | MN, OGA | — |
| 6I9L | JmjC domain-containing protein 5 (JMJD5) in complex with Mn and pyridine-2,4-dicarboxylic acid… | x-ray diffraction | A | MN, PD2 | — |
| 6I9L | Jmjc domain-containing protein 5 (JMJD5) in complex with mn and pyridine-2,4-dicarboxylic acid… | x-ray diffraction | A | MN, PD2 | — |
| 6I9M | JmjC domain-containing protein 5 (JMJD5) in complex with Mn and R-2-hydroxyglutarate | x-ray diffraction | A | MN, 2HG | 1 (best 0.52) |
| 6I9M | Jmjc domain-containing protein 5 (JMJD5) in complex with mn and R-2- hydroxyglutarate | x-ray diffraction | A | MN, 2HG | — |
| 6I9N | Jmjc domain-containing protein 5 (JMJD5) in complex with mn and L-2- hydroxyglutarate | x-ray diffraction | A | MN, S2G | — |
| 7DYT | Human JMJD5 in complex with mn and 5-((4-METHOXYBENZYL)AMINO)PYRIDINE- 2,4-dicarboxylic acid. | x-ray diffraction | A | MN, HR3 | — |
| 7DYU | Human JMJD5 in complex with mn and 5-((4-PHENYLBUTYL)AMINO)PYRIDINE-2, 4-dicarboxylic acid. | x-ray diffraction | A | MN, HR9 | — |
| 7DYV | Human JMJD5 in complex with MN and 5-(benzylamino)pyridine-2,4-dicarboxylic acid. | x-ray diffraction | A | MN, HRF | — |
| 7DYV | Human JMJD5 in complex with mn and 5-(BENZYLAMINO)PYRIDINE-2,4- dicarboxylic acid. | x-ray diffraction | A | MN, HRF | — |
| 7DYW | Human JMJD5 in complex with MN and 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid. | x-ray diffraction | A | HRL, MN | — |
| 7DYW | Human JMJD5 in complex with mn and 5-((2-METHOXYBENZYL)AMINO)PYRIDINE- 2,4-dicarboxylic acid. | x-ray diffraction | A | HRL, MN | — |
| 7DYX | Human JMJD5 in complex with mn and 5-((2-CYCLOPROPYLBENZYL)AMINO) pyridine-2,4-dicarboxylic acid. | x-ray diffraction | A | MN, HRR | — |
| Q8N371 | AlphaFold monomer V2.0 prediction for bifunctional peptidase and arginyl-hydroxylase JMJD5 (Q8N371) | — | — | — |
Ligands
- MN · Manganese (II) ion · in 23 records
- AKG · 2-oxoglutaric acid · in 7 records
- OGA · N-oxalylglycine · in 5 records
- ZN · Zinc ion · in 4 records
- 2HG · (2R)-2-hydroxypentanedioic acid · in 2 records
- HRF · 5-(benzylamino)pyridine-2,4-dicarboxylic acid · in 2 records
- HRL · 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid · in 2 records
- PD2 · Pyridine-2,4-dicarboxylic acid · in 2 records
- 2MR · N3, N4-dimethylarginine · in 1 record
- HR3 · 5-((4-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid · in 1 record
- HR9 · 5-(4-phenylbutylamino)pyridine-2,4-dicarboxylic acid · in 1 record
- HRR · 5-((2-cyclopropylbenzyl)amino)pyridine-2,4-dicarboxylic acid · in 1 record
- S2G · (2S)-2-hydroxypentanedioic acid · in 1 record
Elsewhere
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