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Ligand · NMM

NMM · (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid

NMM, (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid (C7 H16 N4 O2, 188.2 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
NMM
Formula
C7 H16 N4 O2
Class
ligand
Structures
8
PDB entries
4

Binding sites

NMM in 8 structures; the first of them:

  • 5FBJ · Complex structure of JMJD5 and substrate · NMM A502 · binds GLU238, TYR243, TYR272, ALA274, GLN275, TRP310, ILE317, SER318 and 3 more
  • 6AVS · Complex structure of JMJD5 and Symmetric Monomethyl-Arginine (MMA) · NMM A502 · binds GLU238, TYR243, TYR272, ALA274, GLN275, TRP310, ILE317, SER318 and 5 more
  • 6MEV · Structure of JMJD6 bound to Mono-Methyl Arginine. · NMM A403 · binds PHE133, THR184, GLY185, ILE186, HIS187, ASP189, PRO190, ASP230 and 1 more
  • 6OI1 · Crystal structure of human WDR5 in complex with monomethyl L-arginine · NMM A404 · binds SER49, SER91, ASP92, PHE133, CYS134, SER175, TYR260, CYS261 and 2 more
  • 5FBJ · Complex structure of JMJD5 and substrate · NMM A502 · binds GLU238, TYR243, TYR272, ALA274, GLN275, TRP310, ILE317, SER318 and 3 more
  • 6AVS · Complex structure of JMJD5 and symmetric monomethyl-arginine (mma) · NMM A502 · binds GLU238, TYR243, TYR272, ALA274, GLN275, TRP310, ILE317, SER318 and 5 more
  • 6MEV · Structure of JMJD6 bound to mono-methyl arginine. · NMM A403 · binds PHE133, THR184, GLY185, ILE186, HIS187, ASP189, PRO190, ASP230 and 1 more
  • 6OI1 · Crystal structure of human WDR5 in complex with monomethyl L-arginine · NMM A404 · binds SER49, SER91, ASP92, PHE133, CYS134, SER175, TYR260, CYS261 and 2 more

Residues it binds most

ASP 14, HIS 12, ILE 12, PHE 10, SER 6, THR 8, TRP 6, TYR 6, GLY 8, PRO 6 (residue and the binding sites it lines).

Found with

  • AKG · 2-oxoglutaric acid
  • ZN · Zinc ion
  • FE · Fe (III) ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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