UniProt Q8IDR3
Myosin-A (Q8IDR3)
Myosin-A (UniProt Q8IDR3): 24 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 112 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8IDR3
- Protein
- Myosin-A
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 112 · 9 records with a druggable one
Structures
25 records of Q8IDR3 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4MZJ | Crystal Structure of MTIP from Plasmodium falciparum in complex with pGly[801,805], a stapled myoA… | x-ray diffraction | T | — | — |
| 4MZJ | Crystal structure of mtip from plasmodium falciparum in complex with PGLY[801,805], a stapled myoa… | x-ray diffraction | T | — | — |
| 4MZK | Crystal Structure of MTIP from Plasmodium falciparum in complex with pGly[807,811], a stapled myoA… | x-ray diffraction | T | — | — |
| 4MZK | Crystal structure of mtip from plasmodium falciparum in complex with PGLY[807,811], a stapled myoa… | x-ray diffraction | T | — | — |
| 4MZL | Crystal structure of mtip from plasmodium falciparum in complex with hbs myoa, a hydrogen bond… | x-ray diffraction | C, D | — | — |
| 4R1E | Crystal Structure of MTIP from Plasmodium falciparum in complex with a peptide-fragment chimera | x-ray diffraction | B | — | — |
| 4R1E | Crystal structure of mtip from plasmodium falciparum in complex with a peptide-fragment chimera | x-ray diffraction | B | — | — |
| 6I7D | Plasmodium falciparum Myosin A, post-rigor and rigor-like states | x-ray diffraction | A, B, C, D | — | 20 (best 0.85) |
| 6I7D | Plasmodium falciparum myosin a, post-rigor and rigor-like states | x-ray diffraction | A, B, C, D | — | — |
| 6I7E | Plasmodium falciparum Myosin A, Pre-powerstroke | x-ray diffraction | A | ADP, MG, VO4 | — |
| 6I7E | Plasmodium falciparum myosin a, pre-powerstroke | x-ray diffraction | A | ADP, MG, VO4 | — |
| 6TU7 | Structure of PfMyoA decorated Plasmodium Act1 filament | electron microscopy | AP1, GP1 | — | 13 (best 0.81) |
| 6YCX | Plasmodium falciparum Myosin A full-length, pre-powerstroke state | x-ray diffraction | A, B | ADP, VO4, MG | 19 (best 0.86) |
| 6YCX | Plasmodium falciparum myosin a full-length, pre-powerstroke state | x-ray diffraction | A, B | ADP, VO4, MG | — |
| 6YCY | Plasmodium falciparum Myosin A full-length, post-rigor state | x-ray diffraction | A | SO4, MG, ADP | 12 (best 0.82) |
| 6YCY | Plasmodium falciparum myosin a full-length, post-rigor state | x-ray diffraction | A | SO4, MG, ADP | — |
| 6YCZ | Plasmodium falciparum Myosin A delta-Nter, Post-Rigor state | x-ray diffraction | A | SO4, MG, ADP | 10 (best 0.81) |
| 6YCZ | Plasmodium falciparum myosin a delta-nter, post-rigor state | x-ray diffraction | A | SO4, MG, ADP | — |
| 6ZN3 | Plasmodium facliparum glideosome trimeric sub-complex | x-ray diffraction | C, F, I, L, O | — | 8 (best 0.71) |
| 6ZN3 | Plasmodium facliparum glideosome trimeric sub-complex | x-ray diffraction | C, F, I, L, O | — | — |
| 7ALN | Cryo-EM structure of the divergent actomyosin complex from Plasmodium falciparum Myosin A in the… | electron microscopy | F | — | — |
| 7ALN | Cryo-EM structure of the divergent actomyosin complex from plasmodium falciparum myosin a in the… | electron microscopy | F | — | — |
| 8A12 | Plasmodium falciparum Myosin A full-length, post-rigor state complexed to Mg.ATP-gamma-S | x-ray diffraction | A | ADP, SO4, MG | 11 (best 0.79) |
| 8CDM | Plasmodium falciparum Myosin A full-length, post-rigor state complexed to the inhibitor KNX-002 | x-ray diffraction | A | KQ0 | 9 (best 0.81) |
| Q8IDR3 | AlphaFold monomer V2.0 prediction for myosin-a (Q8IDR3) | predicted | A | — | 10 (best 0.77) |
Ligands
Experiment against prediction
- 6I7D chain C against the predicted model Q8IDR3: TM-score 0.97, RMSD 1.74 Å
- 6I7D chain C against the predicted model Q8IDR3: TM-score 0.97, RMSD 1.74 Å
- 6I7D chain B against the predicted model Q8IDR3: TM-score 0.96, RMSD 1.96 Å
- 6I7D chain B against the predicted model Q8IDR3: TM-score 0.96, RMSD 1.96 Å
- 6I7D chain A against the predicted model Q8IDR3: TM-score 0.95, RMSD 2.09 Å
- 6I7D chain A against the predicted model Q8IDR3: TM-score 0.95, RMSD 2.09 Å
- 6I7D chain D against the predicted model Q8IDR3: TM-score 0.95, RMSD 2.28 Å
- 6I7D chain D against the predicted model Q8IDR3: TM-score 0.95, RMSD 2.28 Å
- 7ALN chain F against the predicted model Q8IDR3: TM-score 0.94, RMSD 2.45 Å
- 7ALN chain F against the predicted model Q8IDR3: TM-score 0.94, RMSD 2.45 Å
Elsewhere
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