UniProt Q83883
3C-like protease (Q83883)
3C-like protease (UniProt Q83883), EC 2.7.7.48, 3.4.22.66: 55 experimental structures on GenesisL1, 16 ligands bound, 16 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q83883
- Protein
- 3C-like protease
- EC
- 2.7.7.48, 3.4.22.66, 3.6.1.15
- Experimental structures
- 55
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 16 · 5 records with a druggable one
Structures
55 records of Q83883 in the MolNFT archive: 55 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FYQ | Crystal Structure of the Norwalk Virus Protease | x-ray diffraction | A | — | — |
| 2FYQ | Crystal structure of the norwalk virus protease | x-ray diffraction | A | — | — |
| 2FYR | Crystal Structure of Norwalk Virus Protease grown in the presence of AEBSF | x-ray diffraction | A | — | — |
| 2FYR | Crystal structure of norwalk virus protease grown in the presence of aebsf | x-ray diffraction | A | — | — |
| 2LNC | Solution NMR structure of Norwalk virus protease | solution nmr | A | — | — |
| 2LNC | Solution NMR structure of norwalk virus protease | solution nmr | A | — | — |
| 3UR6 | 1.5A resolution structure of apo Norwalk Virus Protease | x-ray diffraction | A, B | — | — |
| 3UR6 | 1.5A resolution structure of apo norwalk virus protease | x-ray diffraction | A, B | — | — |
| 3UR9 | 1.65A resolution structure of Norwalk Virus Protease Containing a covalently bound dipeptidyl… | x-ray diffraction | A, B | — | — |
| 3UR9 | 1.65A resolution structure of norwalk virus protease containing a covalently bound dipeptidyl… | x-ray diffraction | A, B | — | — |
| 4IMQ | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | x-ray diffraction | A | — | — |
| 4IMQ | Structural basis of substrate specificity and protease inhibition in norwalk virus | x-ray diffraction | A | — | — |
| 4IMZ | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | x-ray diffraction | A | — | — |
| 4IMZ | Structural basis of substrate specificity and protease inhibition in norwalk virus | x-ray diffraction | A | — | — |
| 4IN1 | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | x-ray diffraction | A | — | — |
| 4IN1 | Structural basis of substrate specificity and protease inhibition in norwalk virus | x-ray diffraction | A | — | — |
| 4IN2 | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | x-ray diffraction | A, B | — | — |
| 4IN2 | Structural basis of substrate specificity and protease inhibition in norwalk virus | x-ray diffraction | A, B | — | — |
| 4INH | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4INH | Structural basis of substrate specificity and protease inhibition in norwalk virus | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4XBB | 1.85A resolution structure of Norovirus 3CL protease complex with a covalently bound dipeptidyl… | x-ray diffraction | A | — | — |
| 4XBB | 1.85A resolution structure of norovirus 3CL protease complex with a covalently bound dipeptidyl… | x-ray diffraction | A | — | — |
| 4XBC | 1.60 A resolution structure of Norovirus 3CL protease complex with a covalently bound dipeptidyl… | x-ray diffraction | A | — | — |
| 4XBC | 1.60 a resolution structure of norovirus 3CL protease complex with a covalently bound dipeptidyl… | x-ray diffraction | A | — | — |
| 4XBD | 1.45A resolution structure of Norovirus 3CL protease complex with a covalently bound dipeptidyl… | x-ray diffraction | A, B | — | — |
| 4XBD | 1.45A resolution structure of norovirus 3CL protease complex with a covalently bound dipeptidyl… | x-ray diffraction | A, B | — | — |
| 5DG6 | 2.35A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable… | x-ray diffraction | A, B | CL, V66 | 2 (best 0.64) |
| 5DG6 | 2.35A resolution structure of norovirus 3CL protease in complex an oxadiazole-based, cell permeable… | x-ray diffraction | A, B | — | — |
| 5DGJ | 1.0A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable… | x-ray diffraction | A | — | — |
| 5DGJ | 1.0A resolution structure of norovirus 3CL protease in complex an oxadiazole-based, cell permeable… | x-ray diffraction | A | — | — |
| 5E0G | 1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic… | x-ray diffraction | A | CL, 5LG | 1 (best 0.35) |
| 5E0G | 1.20 a resolution structure of norovirus 3CL protease in complex with a triazole-based macrocyclic… | x-ray diffraction | A | — | — |
| 5E0H | 1.95 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic… | x-ray diffraction | A, B | 5LH | — |
| 5E0H | 1.95 a resolution structure of norovirus 3CL protease in complex with a triazole-based macrocyclic… | x-ray diffraction | A, B | — | — |
| 5E0J | 1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic… | x-ray diffraction | A | CL, 5LJ | — |
| 5E0J | 1.20 a resolution structure of norovirus 3CL protease in complex with a triazole-based macrocyclic… | x-ray diffraction | A | — | — |
| 5T6D | 2.10 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7l… | x-ray diffraction | A, B | N38 | 3 (best 0.64) |
| 5T6D | 2.10 a resolution structure of norovirus 3CL protease in complex with the dipeptidyl inhibitor 7L… | x-ray diffraction | A, B | N38 | — |
| 5T6F | 1.90 a resolution structure of norovirus 3CL protease in complex with the dipeptidyl inhibitor 7L… | x-ray diffraction | A, B | N38 | — |
| 5T6G | 2.45 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7m… | x-ray diffraction | A, B | N40 | 3 (best 0.66) |
| 5T6G | 2.45 a resolution structure of norovirus 3CL protease in complex with the dipeptidyl inhibitor 7M… | x-ray diffraction | A, B | N40 | — |
| 5TG1 | 1.40 a resolution structure of norovirus 3CL protease in complex with the a M-chlorophenyl… | x-ray diffraction | A | CL, V56 | — |
| 5TG2 | 1.75 a resolution structure of norovirus 3CL protease in complex with the a N-pentyl substituted… | x-ray diffraction | A | V69 | — |
| 5WEJ | 1.95 a resolution structure of norovirus 3CL protease in complex with a dipeptidyl… | x-ray diffraction | A, B | V45 | — |
| 6BIB | 1.95 a resolution structure of norovirus 3CL protease in complex with a triazole-based macrocyclic… | x-ray diffraction | A, B | DW7 | — |
| 6BIC | 2.25 a resolution structure of norovirus 3CL protease in complex with a triazole-based macrocyclic… | x-ray diffraction | A, B | 5LH | — |
| 6BID | 1.15 a resolution structure of norovirus 3CL protease in complex with a triazole-based macrocyclic… | x-ray diffraction | A | DW4 | — |
| 6W5H | 1.85 A resolution structure of Norovirus 3CL protease in complex with inhibitor 5d | x-ray diffraction | A, B, C, D | TKP | 5 (best 0.64) |
| 6W5H | 1.85 a resolution structure of norovirus 3CL protease in complex with inhibitor 5D | x-ray diffraction | A, B, C, D | TKP | — |
| 6W5J | 1.85 A resolution structure of Norovirus 3CL protease in complex with inhibitor 7d | x-ray diffraction | A, B | TKS | 2 (best 0.63) |
| 6W5J | 1.85 a resolution structure of norovirus 3CL protease in complex with inhibitor 7D | x-ray diffraction | A, B | TKS | — |
| 6W5K | 1.95 A resolution structure of Norovirus 3CL protease in complex with inhibitor 5g | x-ray diffraction | A, B, C, D | TKV | — |
| 6W5K | 1.95 a resolution structure of norovirus 3CL protease in complex with inhibitor 5G | x-ray diffraction | A, B, C, D | TKV | — |
| 6W5L | 2.1 A resolution structure of Norovirus 3CL protease in complex with inhibitor 7g | x-ray diffraction | A, B, C, D | T0D | — |
| 6W5L | 2.1 a resolution structure of norovirus 3CL protease in complex with inhibitor 7G | x-ray diffraction | A, B, C, D | T0D | — |
Ligands
- CL · Chloride ion · in 4 records
- N38 · 3-cyclohexyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-{[3-(4-methoxyphenoxy) propyl]sulfonyl}-L-alaninamide · in 3 records
- 5LH · (phenylmethyl) ~{N}-[(9~{S},12~{S},15~{S})-9-(hydroxymethyl)-12-(2-methylpropyl)-6,11,14-tris(oxidanylidene)-1,5,10,13,18,19-hexazabicyclo[15.2.1]icosa-17(20),18-dien-15-yl]carbamate · in 2 records
- N40 · 3-cyclohexyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-(octylsulfonyl)-L-alaninamide · in 2 records
- T0D · (2~{S})-~{N}-[(1~{R})-1-[bis($l^{1}-oxidanyl)-methoxy-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{R})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[[2-(3-chlorophenyl)-2-methyl-propoxy]-oxidanylidene-methyl]amino]-4-methyl-pentanamide · in 2 records
- TKP · 2-(3-chlorophenyl)-2-methylpropyl [(2S)-3-cyclohexyl-1-({(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-1-oxopropan-2-yl]carbamate · in 2 records
- TKS · 2-(3-chlorophenyl)-2-methylpropyl [(2S)-3-cyclohexyl-1-({(1R,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-1-sulfanylpropan-2-yl}amino)-1-oxopropan-2-yl]carbamate · in 2 records
- TKV · N~2~-{[2-(3-chlorophenyl)-2-methylpropoxy]carbonyl}-N-{(1R,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-1-sulfanylpropan-2-yl}-L-leucinamide · in 2 records
- 5LG · (phenylmethyl) ~{N}-[(8~{S},11~{S},14~{S})-8-(hydroxymethyl)-11-(2-methylpropyl)-5,10,13-tris(oxidanylidene)-1,4,9,12,17,18-hexazabicyclo[14.2.1]nonadeca-16(19),17-dien-14-yl]carbamate · in 1 record
- 5LJ · (phenylmethyl) ~{N}-[(12~{S},15~{S},18~{S})-15-(cyclohexylmethyl)-12-(hydroxymethyl)-9,14,17-tris(oxidanylidene)-1,8,13,16,21,22-hexazabicyclo[18.2.1]tricosa-20(23),21-dien-18-yl]carbamate · in 1 record
- DW4 · Benzyl [(8S,11S,14S)-11-(cyclohexylmethyl)-8-(hydroxymethyl)-5,10,13-trioxo-1,4,9,12,17,18-hexaazabicyclo[14.2.1]nonadeca-16(19),17-dien-14-yl]carbamate · in 1 record
- DW7 · Benzyl [(9S,12S,15S)-12-(cyclohexylmethyl)-9-(hydroxymethyl)-6,11,14-trioxo-1,5,10,13,18,19-hexaazabicyclo[15.2.1]icosa-17(20),18-dien-15-yl]carbamate · in 1 record
- V45 · (2S)-2-{(5S)-5-[(3-chlorophenyl)methyl]-2-oxo-1,3-oxazolidin-3-yl}-4-methyl-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}pentanamide · in 1 record
- V56 · (4S,7S,17S)-17-(3-chlorophenyl)-7-(hydroxymethyl)-4-(2-methylpropyl)-1-oxa-3,6,11-triazacycloheptadecane-2,5, 10-trione · in 1 record
- V66 · tert-butyl [(4S,7S,10S)-7-(cyclohexylmethyl)-10-(hydroxymethyl)-5,8,13-trioxo-23-oxa-6,9,14,21,22-pentaazabicyclo[18.2.1]tricosa-1(22),20-dien-4-yl]carbamate · in 1 record
- V69 · (4S,7S,17R)-7-(hydroxymethyl)-4-(2-methylpropyl)-17-pentyl-1-oxa-3,6,11-triazacycloheptadecane-2,5,10-trione · in 1 record
Elsewhere
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