UniProt Q7K4Y6
Sodium-dependent dopamine transporter (Q7K4Y6)
Sodium-dependent dopamine transporter (UniProt Q7K4Y6): 26 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q7K4Y6
- Protein
- Sodium-dependent dopamine transporter
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 33 · 11 records with a druggable one
Structures
27 records of Q7K4Y6 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XP4 | X-ray structure of Drosophila dopamine transporter in complex with cocaine | x-ray diffraction | A | GLC, Y01, P4G, CLR, COC, NA | 3 (best 0.78) |
| 4XP4 | X-ray structure of drosophila dopamine transporter in complex with cocaine | x-ray diffraction | A | — | — |
| 4XPB | X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to… | x-ray diffraction | A | — | — |
| 4XPB | X-ray structure of drosophila dopamine transporter with subsiteb mutations (D121G/S426M) bound to… | x-ray diffraction | A | — | — |
| 4XPT | X-ray structure of Drosophila dopamine transporter with subsiteB mutations D121G/S426M and EL2… | x-ray diffraction | A | — | — |
| 4XPT | X-ray structure of drosophila dopamine transporter with subsiteb mutations D121G/S426M and EL2… | x-ray diffraction | A | — | — |
| 6M0F | X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) in… | x-ray diffraction | A | CL, CLR, P4G, NA | 5 (best 0.79) |
| 6M0F | X-ray structure of drosophila dopamine transporter with subsiteb mutations (D121G/S426M) in… | x-ray diffraction | A | CL, CLR, P4G, NA | — |
| 6M0Z | X-ray structure of Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in… | x-ray diffraction | A | CLR, Y01, NA, CL, LNR | — |
| 6M0Z | X-ray structure of drosophila dopamine transporter with net-like mutations (D121G/S426M/F471L) in… | x-ray diffraction | A | CLR, Y01, NA, CL, LNR | — |
| 6M2R | X-ray structure of a functional Drosophila dopamine transporter in L-norepinephrine bound form | x-ray diffraction | A | Y01, CLR, LNR, CL, NA, D10 | 3 (best 0.80) |
| 6M2R | X-ray structure of a functional drosophila dopamine transporter in L- norepinephrine bound form | x-ray diffraction | A | Y01, CLR, LNR, CL, NA, D10 | — |
| 6M38 | X-ray structure of a Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) in… | x-ray diffraction | A | 29E, Y01, NA, CL, CLR | 3 (best 0.78) |
| 6M38 | X-ray structure of a drosophila dopamine transporter with subsiteb mutations (D121G/S426M) in… | x-ray diffraction | A | 29E, Y01, NA, CL, CLR | — |
| 6M3Z | X-ray structure of a Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in… | x-ray diffraction | A | GLC, F0F, D10, CL, NA, Y01 | 6 (best 0.80) |
| 6M3Z | X-ray structure of a drosophila dopamine transporter with net-like mutations (D121G/S426M/F471L) in… | x-ray diffraction | A | GLC, F0F, D10, CL, NA, Y01 | — |
| 6M47 | X-ray structure of a Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in… | x-ray diffraction | A | GLC, CLR, Y01, NA, CL, F1U | 3 (best 0.80) |
| 6M47 | X-ray structure of a drosophila dopamine transporter with net-like mutations (D121G/S426M/F471L) in… | x-ray diffraction | A | GLC, CLR, Y01, NA, CL, F1U | — |
| 7WGD | X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like… | x-ray diffraction | A | NA, CL, Y01, CLR | 2 (best 0.79) |
| 7WGD | X-ray structure of thermostabilized drosophila dopamine transporter with GABA TRANSPORTER1-like… | x-ray diffraction | A | NA, CL, Y01, CLR | — |
| 7WGT | X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like… | x-ray diffraction | A | 9BC, CLR, NA, CL, Y01 | 2 (best 0.78) |
| 7WGT | X-ray structure of thermostabilized drosophila dopamine transporter with GABA TRANSPORTER1-like… | x-ray diffraction | A | 9BC, CLR, NA, CL, Y01 | — |
| 7WLW | X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like… | x-ray diffraction | A | CL, NA, 1WR, Y01, CLR | 2 (best 0.80) |
| 7WLW | X-ray structure of thermostabilized drosophila dopamine transporter with GABA TRANSPORTER1-like… | x-ray diffraction | A | CL, NA, 1WR, Y01, CLR | — |
| 9EUO | Outward-open structure of Drosophila dopamine transporter bound to an atypical non-competitive… | electron microscopy | A | A1H8F, Y01, CLR, NA, CL | 3 (best 0.79) |
| 9EUP | Inhibitor-free outward-open structure of Drosophila dopamine transporter | electron microscopy | A | Y01, CLR, NA, CL | 1 (best 0.78) |
| Q7K4Y6 | AlphaFold monomer V2.0 prediction for sodium-dependent dopamine transporter (Q7K4Y6) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 21 records
- CLR · Cholesterol · in 21 records
- NA · Sodium ion · in 21 records
- Y01 · Cholesterol hemisuccinate · in 19 records
- D10 · Decane · in 6 records
- GLC · alpha-D-glucopyranose · in 5 records
- LNR · L-norepinephrine · in 4 records
- P4G · 1-ethoxy-2-(2-ethoxyethoxy)ethane · in 3 records
- 1WR · (3S)-1-(4,4-diphenylbut-3-enyl)piperidine-3-carboxylic acid · in 2 records
- 29E · (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl) propan-1-amine · in 2 records
- 9BC · 1-(2-{[(diphenylmethylidene)amino]oxy}ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid · in 2 records
- F0F · (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide · in 2 records
- F1U · (1S,2S)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexan-1-ol · in 2 records
- A1H8F · N-[3-(6-chloranyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)propyl]butanamide · in 1 record
- COC · Cocaine · in 1 record
Experiment against prediction
- 4XP4 chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.47 Å
- 4XP4 chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.47 Å
- 6M38 chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.48 Å
- 6M38 chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.48 Å
- 9EUP chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.50 Å
- 9EUO chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.52 Å
- 6M0Z chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.53 Å
- 6M0Z chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.53 Å
- 4XPB chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.52 Å
- 4XPB chain A against the predicted model Q7K4Y6: TM-score 1.00, RMSD 0.52 Å
Elsewhere
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