UniProt Q6P988
Palmitoleoyl-protein carboxylesterase NOTUM (Q6P988)
Palmitoleoyl-protein carboxylesterase NOTUM (UniProt Q6P988), EC 3.1.1.98: 181 experimental structures on GenesisL1, 120 ligands bound, 80 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q6P988
- Protein
- Palmitoleoyl-protein carboxylesterase NOTUM
- EC
- 3.1.1.98
- Experimental structures
- 181
- Predicted models
- 0
- Ligands
- 120
- Pockets
- 80 · 36 records with a druggable one
Structures
181 records of Q6P988 in the MolNFT archive: 181 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UYU | Structure of the wnt deacylase notum - crystal form I iodide complex - 2.3A | x-ray diffraction | A, B | — | — |
| 4UYU | Structure of the wnt deacylase notum - crystal form I iodide complex - 2.3A | x-ray diffraction | A, B | — | — |
| 4UYW | Structure of the wnt deacylase notum - crystal form I heparin fragment complex - 1.7A | x-ray diffraction | A, B | — | — |
| 4UYW | Structure of the wnt deacylase notum - crystal form I heparin fragment complex - 1.7A | x-ray diffraction | A, B | — | — |
| 4UYZ | Structure of the wnt deacylase notum - crystal form II - 2.8A | x-ray diffraction | A, B, C, D | — | — |
| 4UYZ | Structure of the wnt deacylase notum - crystal form II - 2.8A | x-ray diffraction | A, B, C, D | — | — |
| 4UZ1 | Structure of the wnt deacylase notum - crystal form III - 1.4A | x-ray diffraction | A | — | — |
| 4UZ1 | Structure of the wnt deacylase notum - crystal form III - 1.4A | x-ray diffraction | A | — | — |
| 4UZ5 | Structure of the wnt deacylase notum - crystal form IV - 2.1A | x-ray diffraction | A | — | — |
| 4UZ5 | Structure of the wnt deacylase notum - crystal form IV - 2.1A | x-ray diffraction | A | — | — |
| 4UZ6 | Structure of the wnt deacylase notum - crystal form V - sos complex - 1.9A | x-ray diffraction | A, B | — | — |
| 4UZ6 | Structure of the wnt deacylase notum - crystal form V - sos complex - 1.9A | x-ray diffraction | A, B | — | — |
| 4UZ7 | Structure of the wnt deacylase notum - crystal form VI - 2.2A | x-ray diffraction | A, B | — | — |
| 4UZ7 | Structure of the wnt deacylase notum - crystal form VI - 2.2A | x-ray diffraction | A, B | — | — |
| 4UZ9 | Structure of the wnt deacylase notum - crystal form VII - sos complex - 2.2A | x-ray diffraction | A | — | — |
| 4UZ9 | Structure of the wnt deacylase notum - crystal form VII - sos complex - 2.2A | x-ray diffraction | A | — | — |
| 4UZA | Structure of the wnt deacylase notum - crystal form VIII - phosphate complex - 2.4A | x-ray diffraction | A | — | — |
| 4UZA | Structure of the wnt deacylase notum - crystal form VIII - phosphate complex - 2.4A | x-ray diffraction | A | — | — |
| 4UZL | Structure of the wnt deacylase notum - crystal form I myristoleate complex - 2.1A | x-ray diffraction | A, B | — | — |
| 4UZL | Structure of the wnt deacylase notum - crystal form I myristoleate complex - 2.1A | x-ray diffraction | A, B | — | — |
| 4UZQ | Structure of the wnt deacylase notum in complex with O-palmitoleoyl serine - crystal form IX - 1.5A | x-ray diffraction | A | — | — |
| 4UZQ | Structure of the wnt deacylase notum in complex with O-palmitoleoyl serine - crystal form IX - 1.5A | x-ray diffraction | A | — | — |
| 4WBH | Structure of the wnt deacylase notum - crystal form I apo - 2.2A | x-ray diffraction | A, B | — | — |
| 4WBH | Structure of the wnt deacylase notum - crystal form I apo - 2.2A | x-ray diffraction | A, B | — | — |
| 6R8P | Notum fragment 723 | x-ray diffraction | A | NAG, SO4, JVB | — |
| 6R8Q | Structure of the wnt deacylase notum in complex with a benzotriazole fragment | x-ray diffraction | A | NAG, SO4, JV5 | 2 (best 0.64) |
| 6R8Q | Structure of the wnt deacylase notum in complex with a benzotriazole fragment | x-ray diffraction | A | NAG, SO4, JV5 | — |
| 6R8R | Structure of the Wnt deacylase Notum in complex with isoquinoline 45 | x-ray diffraction | A | NAG, JV8, SO4 | 2 (best 0.66) |
| 6R8R | Structure of the wnt deacylase notum in complex with isoquinoline 45 | x-ray diffraction | A | NAG, JV8, SO4 | — |
| 6T2H | FURANO[2,3-D]PRYMIDINE amides as notum inhibitors | x-ray diffraction | A | SO4, NAG, M9N | — |
| 6T2K | Furano[2,3-d]prymidine amides as Notum inhibitors | x-ray diffraction | A | SO4, NAG, M9K | — |
| 6T2K | FURANO[2,3-D]PRYMIDINE amides as notum inhibitors | x-ray diffraction | A | SO4, NAG, M9K | — |
| 6TR5 | Melatonin-Notum complex | x-ray diffraction | A | ML1, NAG, SO4 | — |
| 6TR5 | Melatonin-notum complex | x-ray diffraction | A | ML1, NAG, SO4 | — |
| 6TR6 | N-acetylserotonin-notum complex | x-ray diffraction | A | NAG, SO4, ASE | — |
| 6TR7 | N-[2-(5-fluoro-1H-indol-3-YL)ETHYL]ACETAMIDE-notum complex | x-ray diffraction | A | SO4, NAG, HWH | — |
| 6TUZ | Theophylline-notum complex | x-ray diffraction | A | SO4, NAG, TEP | — |
| 6TV4 | CFF-Notum complex | x-ray diffraction | A | SO4, NAG, CFF | — |
| 6TV4 | Cff-notum complex | x-ray diffraction | A | SO4, NAG, CFF | — |
| 6YSK | 1-phenylpyrroles and 1-enylpyrrolidines as inhibitors of Notum | x-ray diffraction | A | NAG, SO4, PJK | 2 (best 0.74) |
| 6YSK | 1-phenylpyrroles and 1-enylpyrrolidines as inhibitors of notum | x-ray diffraction | A | NAG, SO4, PJK | — |
| 6YUW | Structure of the wnt deacylase notum in complex with a pyrrole-3- carboxylic acid fragment 454 | x-ray diffraction | A | SO4, PQZ, NAG | — |
| 6YUY | Structure of the wnt deacylase notum in complex with a pyrrole-3- carboxylic acid fragment 471 | x-ray diffraction | A | SO4, PQH, NAG | — |
| 6YV0 | Structure of the wnt deacylase notum in complex with a pyrrolidine-3- carboxylic acid fragment 587 | x-ray diffraction | A | SO4, PQT, NAG | — |
| 6YV2 | Structure of the wnt deacylase notum in complex with a pyrrolidine-3- carboxylic acid fragment 598 | x-ray diffraction | A | NAG, PUE, SO4 | — |
| 6YV4 | Structure of the wnt deacylase notum in complex with a pyrrole-3-carboxylic acid fragment 686 | x-ray diffraction | A | PQK, NAG, SO4 | — |
| 6YV4 | Structure of the wnt deacylase notum in complex with a pyrrole-3- carboxylic acid fragment 686 | x-ray diffraction | A | PQK, NAG, SO4 | — |
| 6YXI | Structure of notum in complex with a 1-(3-chlorophenyl)-2,5-dimethyl- 1H-pyrrole-3-carboxylic acid… | x-ray diffraction | A | PZ8, NAG, SO4 | — |
| 6ZUV | Notum fragment 286 | x-ray diffraction | A | NAG, SO4, B1J | — |
| 6ZVL | ARUK3000263 complex with notum | x-ray diffraction | A | NAG, SO4, QR2 | — |
| 6ZYF | NOTUM_GHRELIN complex | x-ray diffraction | A, B | NAG, K4Q | — |
| 7ARG | Notum in complex with ARUK3002704 | x-ray diffraction | A | NAG, SO4, RW8 | 2 (best 0.75) |
| 7ARG | Notum in complex with ARUK3002704 | x-ray diffraction | A | NAG, SO4, RW8 | — |
| 7B2V | Notum complex with ARUK3003906 | x-ray diffraction | A | NAG, SO4, SRH | — |
| 7B2Y | Notum complex with ARUK3003910 | x-ray diffraction | A | NAG, SO4, SRQ | 3 (best 0.71) |
| 7B2Y | Notum complex with ARUK3003910 | x-ray diffraction | A | NAG, SO4, SRQ | — |
| 7B2Z | Notum complex with ARUK3003907 | x-ray diffraction | A | SO4, SQW | 2 (best 0.72) |
| 7B2Z | Notum complex with ARUK3003907 | x-ray diffraction | A | SO4, SQW | — |
| 7B37 | Notum complex with ARUK3003718 | x-ray diffraction | A | NAG, SO4, SRK | — |
| 7B3F | Notum S232A in complex with ARUK3003718 | x-ray diffraction | A | NAG, SO4, SRK | — |
121 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 155 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 142 records
- A6Z · 2-[4-(3-chlorophenyl)piperazin-1-ium-1-yl]ethanenitrile · in 2 records
- AW7 · 2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine · in 2 records
- AXV · 1~{H}-benzimidazol-2-ylcyanamide · in 2 records
- AYR · (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl) penta-2,4-dien-1-one · in 2 records
- CFF · Caffeine · in 2 records
- EJW · (3-phenyl-1,2-oxazol-5-yl)methylazanium · in 2 records
- GW1 · (4-chloranyl-2-methyl-pyrazol-3-yl)-piperidin-1-yl-methanone · in 2 records
- JFS · [4-(1H-benzimidazol-1-yl)phenyl]methanol · in 2 records
- JHJ · N-(4-methoxyphenyl)-N'-pyridin-4-ylurea · in 2 records
- JV5 · ~{N}-(1~{H}-benzotriazol-5-yl)-2-(2-methylphenoxy) ethanamide · in 2 records
- JV8 · ~{N}-isoquinolin-6-yl-2-(2-methylphenoxy)ethanamide · in 2 records
- LO5 · 1-(1,3-benzodioxol-5-yl)-~{N}-[[(2~{R})-oxolan-2-yl]methyl]methanamine · in 2 records
- M9K · 2-(6-chloranyl-7-cyclopropyl-thieno[3,2-d]pyrimidin-4-yl)sulfanylethanoic acid · in 2 records
- ML1 · N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide · in 2 records
- NUM · N-[2-(4-hydroxyphenyl)ethyl]pyridine-2-carboxamide · in 2 records
- NW7 · 3-ethyl-5-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,2-oxazole-4-carboxamide · in 2 records
- PJK · (3~{S})-1-[4-chloranyl-3-(trifluoromethyl) phenyl]pyrrolidine-3-carboxylic acid · in 2 records
- PQK · 1-cyclopropyl-2,5-dimethyl-pyrrole-3-carboxylic acid · in 2 records
- QL5 · (2,5-dimethylphenyl) pyridine-4-carboxylate · in 2 records
- ROA · (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid · in 2 records
- RW8 · methyl 4-(2,3-dihydroindol-1-yl)-4-oxidanylidene-butanoate · in 2 records
- SQW · propan-2-yl 4-indol-1-yl-4-oxidanylidene-butanoate · in 2 records
- SRK · 4-(2,3-dihydroindol-1-yl)-4-oxidanylidene-butanoic acid · in 2 records
- SRQ · 2,2-bis(fluoranyl)ethyl 4-(2,3-dihydroindol-1-yl)-4-oxidanylidene-butanoate · in 2 records
- STK · 3-(3-chlorophenyl)sulfanyl-1$l^{4},2,7,8-tetrazabicyclo[4.3.0]nona-1(6),2,4,7-tetraen-9-one · in 2 records
- T3T · 1-(1,3-benzodioxol-5-yl)-~{N}-(pyridin-2-ylmethyl) methanamine · in 2 records
- TE5 · 4-methoxy-6-phenyl-pyrimidin-2-amine · in 2 records
- TE8 · (2~{R})-2-(4-phenylphenoxy)propanoic acid · in 2 records
Elsewhere
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