UniProt Q6L732
Kanamycin B dioxygenase (Q6L732)
Kanamycin B dioxygenase (UniProt Q6L732), EC 1.14.11.37: 22 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 213 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q6L732
- Protein
- Kanamycin B dioxygenase
- EC
- 1.14.11.37
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 213 · 15 records with a druggable one
Structures
23 records of Q6L732 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6S0R | The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus complex… | x-ray diffraction | A, B, C, D, E, F | NI, SO4, CL | 12 (best 0.71) |
| 6S0R | The crystal structure of kanamycin B dioxygenase (kanj) from streptomyces kanamyceticus complex… | x-ray diffraction | A, B, C, D, E, F | NI, SO4, CL | — |
| 6S0S | The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | NI, AKG, RIO, CL | 13 (best 0.69) |
| 6S0S | The crystal structure of kanamycin B dioxygenase (kanj) from streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | NI, AKG, RIO, CL | — |
| 6S0T | The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | NI, SO4, IOD | 14 (best 0.66) |
| 6S0T | The crystal structure of kanamycin B dioxygenase (kanj) from streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | NI, SO4, IOD | — |
| 6S0U | The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | AKG, NI, CL, NA | 14 (best 0.69) |
| 6S0U | The crystal structure of kanamycin B dioxygenase (kanj) from streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | AKG, NI, CL, NA | — |
| 6S0V | The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | NI, SO4, XXX | 15 (best 0.75) |
| 6S0V | The crystal structure of kanamycin B dioxygenase (kanj) from streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | NI, SO4, XXX | — |
| 6S0W | The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | 9CS, NI, SO4 | 15 (best 0.72) |
| 6S0W | The crystal structure of kanamycin B dioxygenase (kanj) from streptomyces kanamyceticus in complex… | x-ray diffraction | A, B, C, D, E, F | 9CS, NI, SO4 | — |
| 7CL2 | The crystal structure of KanJ | x-ray diffraction | A, B, C, D, E, F | NI, SO4 | 14 (best 0.63) |
| 7CL2 | The crystal structure of kanj | x-ray diffraction | A, B, C, D, E, F | NI, SO4 | 14 (best 0.63) |
| 7CL3 | The crystal structure of KanJ in complex with kanamycin B | x-ray diffraction | A, B, C, D, E, F | NI, SO4, 9CS | 16 (best 0.73) |
| 7CL3 | The crystal structure of kanj in complex with kanamycin B | x-ray diffraction | A, B, C, D, E, F | NI, SO4, 9CS | 16 (best 0.73) |
| 7CL4 | The crystal structure of KanJ in complex with N-oxalylglycine | x-ray diffraction | A, B, C, D, E, F | NI, OGA | 14 (best 0.63) |
| 7CL4 | The crystal structure of kanj in complex with N-oxalylglycine | x-ray diffraction | A, B, C, D, E, F | NI, OGA | — |
| 7CL5 | The crystal structure of KanJ in complex with kanamycin B and N-oxalylglycine | x-ray diffraction | A, B, C, D, E, F | NI, OGA, 9CS | 14 (best 0.73) |
| 7CL5 | The crystal structure of kanj in complex with kanamycin B and N- oxalylglycine | x-ray diffraction | A, B, C, D, E, F | NI, OGA, 9CS | 14 (best 0.73) |
| 7CL6 | The crystal structure of KanJ in complex with neamine and N-oxalylglycine | x-ray diffraction | A, B, C, D, E, F | NI, OGA, XXX | 14 (best 0.75) |
| 7CL6 | The crystal structure of kanj in complex with neamine and N- oxalylglycine | x-ray diffraction | A, B, C, D, E, F | NI, OGA, XXX | 14 (best 0.75) |
| Q6L732 | AlphaFold monomer V2.0 prediction for kanamycin B dioxygenase (Q6L732) | predicted | A | — | — |
Ligands
- NI · Nickel (II) ion · in 22 records
- SO4 · Sulfate ion · in 12 records
- 9CS · (1R,2S,3S,4R,6S)-4,6-diamino-3-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside · in 6 records
- CL · Chloride ion · in 6 records
- OGA · N-oxalylglycine · in 6 records
- AKG · 2-oxoglutaric acid · in 4 records
- XXX · (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2, 6-diamino-2,6-dideoxy-alpha-D-glucopyranoside · in 4 records
- IOD · Iodide ion · in 2 records
- NA · Sodium ion · in 2 records
- RIO · Ribostamycin · in 2 records
Experiment against prediction
- 7CL4 chain A against the predicted model Q6L732: TM-score 0.98, RMSD 0.78 Å
- 7CL4 chain A against the predicted model Q6L732: TM-score 0.98, RMSD 0.78 Å
- 6S0V chain E against the predicted model Q6L732: TM-score 0.98, RMSD 0.79 Å
- 6S0V chain E against the predicted model Q6L732: TM-score 0.98, RMSD 0.79 Å
- 6S0W chain E against the predicted model Q6L732: TM-score 0.98, RMSD 0.81 Å
- 6S0W chain E against the predicted model Q6L732: TM-score 0.98, RMSD 0.81 Å
- 7CL5 chain E against the predicted model Q6L732: TM-score 0.98, RMSD 0.82 Å
- 7CL5 chain E against the predicted model Q6L732: TM-score 0.98, RMSD 0.82 Å
- 6S0W chain A against the predicted model Q6L732: TM-score 0.97, RMSD 0.85 Å
- 6S0W chain A against the predicted model Q6L732: TM-score 0.97, RMSD 0.85 Å
Elsewhere
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