UniProt Q6GHP9
Cell division protein FtsZ (Q6GHP9)
Cell division protein FtsZ (UniProt Q6GHP9): 15 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6GHP9
- Protein
- Cell division protein FtsZ
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 27 · 8 records with a druggable one
Structures
16 records of Q6GHP9 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5H5G | Staphylococcus aureus FtsZ-GDP in T and R states | x-ray diffraction | A, B | GDP, CA | 7 (best 0.67) |
| 5H5G | Staphylococcus aureus ftsz-GDP in T and R states | x-ray diffraction | A, B | — | — |
| 5H5H | Staphylococcus aureus FtsZ-GDP R29A mutant in T state | x-ray diffraction | A | GDP, CA | 3 (best 0.58) |
| 5H5H | Staphylococcus aureus ftsz-GDP R29A mutant in T state | x-ray diffraction | A | — | — |
| 5H5I | Staphylococcus aureus FtsZ-GDP R29A mutant in R state | x-ray diffraction | A | GDP | 2 (best 0.65) |
| 5H5I | Staphylococcus aureus ftsz-GDP R29A mutant in R state | x-ray diffraction | A | — | — |
| 5XDT | Staphylococcus aureus FtsZ 12-316 complexed with TXA707 | x-ray diffraction | A | GDP, CA, ZI7, MB3 | 3 (best 0.68) |
| 5XDT | Staphylococcus aureus ftsz 12-316 complexed with TXA707 | x-ray diffraction | A | GDP, CA, ZI7, MB3 | — |
| 5XDU | Staphylococcus aureus FtsZ 12-316 complexed with TXA6101 | x-ray diffraction | A | GDP, CA, ZI6 | 3 (best 0.74) |
| 5XDU | Staphylococcus aureus ftsz 12-316 complexed with TXA6101 | x-ray diffraction | A | GDP, CA, ZI6 | — |
| 5XDV | Staphylococcus aureus FtsZ 12-316 G196S complexed with TXA6101 | x-ray diffraction | A | GDP, CA, ZI6 | 3 (best 0.73) |
| 5XDV | Staphylococcus aureus ftsz 12-316 G196S complexed with TXA6101 | x-ray diffraction | A | GDP, CA, ZI6 | — |
| 5XDW | Staphylococcus aureus FtsZ 12-316 G196S | x-ray diffraction | A | GDP, CA | 3 (best 0.59) |
| 5XDW | Staphylococcus aureus ftsz 12-316 G196S | x-ray diffraction | A | GDP, CA | — |
| 8HTB | Staphylococcus aureus FtsZ 12-316 complexed with TXH9179 | x-ray diffraction | A | GDP, CA, ZI9 | 3 (best 0.66) |
| Q6GHP9 | AlphaFold monomer V2.0 prediction for cell division protein ftsz (Q6GHP9) | predicted | A | — | — |
Ligands
- GDP · Guanosine-5'-diphosphate · in 12 records
- CA · Calcium ion · in 11 records
- ZI6 · 3-[[5-bromanyl-4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl]methoxy]-2,6-bis(fluoranyl)benzamide · in 4 records
- MB3 · 1-methylpyrrolidin-2-one · in 2 records
- ZI7 · 2,6-bis(fluoranyl)-3-[[6-(trifluoromethyl)-[1, 3]thiazolo[5,4-b]pyridin-2-yl]methoxy]benzamide · in 2 records
- ZI9 · 3-[(6-ethynyl-[1,3]thiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-bis(fluoranyl)benzamide · in 1 record
Experiment against prediction
- 5H5G chain B against the predicted model Q6GHP9: TM-score 0.97, RMSD 1.46 Å
- 5H5G chain B against the predicted model Q6GHP9: TM-score 0.97, RMSD 1.46 Å
- 5H5I chain A against the predicted model Q6GHP9: TM-score 0.94, RMSD 1.74 Å
- 5H5I chain A against the predicted model Q6GHP9: TM-score 0.94, RMSD 1.74 Å
- 5XDT chain A against the predicted model Q6GHP9: TM-score 0.89, RMSD 2.44 Å
- 5XDT chain A against the predicted model Q6GHP9: TM-score 0.89, RMSD 2.44 Å
- 5XDU chain A against the predicted model Q6GHP9: TM-score 0.89, RMSD 2.49 Å
- 5XDU chain A against the predicted model Q6GHP9: TM-score 0.89, RMSD 2.49 Å
- 5XDV chain A against the predicted model Q6GHP9: TM-score 0.89, RMSD 2.48 Å
- 5XDV chain A against the predicted model Q6GHP9: TM-score 0.89, RMSD 2.48 Å
Elsewhere
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