MolNFT v1 · #139375 · protein
Staphylococcus aureus ftsz 12-316 complexed with TXA707
5XDT · Cell division protein ftsz: “Staphylococcus aureus ftsz 12-316 complexed with TXA707”. X-ray diffraction, 4 ligands (MB3, GDP, ZI7), 3 pockets (best druggability 0.68). MolNFT v1 #139375 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5XDT
- Type
- protein
- Length
- 306 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division protein ftsz
- UniProt
- Q6GHP9
- Ligands
- MB3, GDP, ZI7, CA
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division protein ftsz | protein | 306 | 46% helix, 23% strand | Q6GHP9 |
Ligands and binding sites
- MB3 · 1-methylpyrrolidin-2-one · ligand · 2 copies · chains A
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- ZI7 · 2,6-bis(fluoranyl)-3-[[6-(trifluoromethyl)-[1, 3]thiazolo[5,4-b]pyridin-2-yl]methoxy]benzamide · ligand · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 214 | 0.68 | 0.85 | 39 | ZI7 |
| 2 | 233 | 0.61 | 0.81 | 40 | GDP, MB3 |
| 3 | 96 | 0.46 | 0.80 | 15 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GHP9
- Elsewhere: RCSB PDB 5XDT · PDBe 5XDT · UniProt Q6GHP9
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