UniProt Q5VYS8
Terminal uridylyltransferase 7 (Q5VYS8)
Terminal uridylyltransferase 7 (UniProt Q5VYS8), EC 2.7.7.52: 12 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 91 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q5VYS8
- Protein
- Terminal uridylyltransferase 7
- EC
- 2.7.7.52
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 91 · 9 records with a druggable one
Structures
13 records of Q5VYS8 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5W0B | Structure of human TUT7 catalytic module (CM) | x-ray diffraction | A, B, C | ZN, SO4, IOD | 16 (best 0.74) |
| 5W0B | Structure of human TUT7 catalytic module (cm) | x-ray diffraction | A, B, C | ZN, SO4, IOD | — |
| 5W0M | Structure of human TUT7 catalytic module (CM) in complex with U5 RNA | x-ray diffraction | A, B, C | SO4, ZN, IOD | 17 (best 0.84) |
| 5W0M | Structure of human TUT7 catalytic module (cm) in complex with U5 RNA | x-ray diffraction | A, B, C | SO4, ZN, IOD | — |
| 5W0N | Structure of human TUT7 catalytic module (CM) in complex with UMPNPP and U2 RNA | x-ray diffraction | A, B, C | MG, 2KH, UPU, ZN, IOD, SO4 | 10 (best 0.83) |
| 5W0N | Structure of human TUT7 catalytic module (cm) in complex with umpnpp and U2 RNA | x-ray diffraction | A, B, C | MG, 2KH, UPU, ZN, IOD, SO4 | — |
| 5W0O | Structure of human TUT7 catalytic module (CM) in complex with dsRNA | x-ray diffraction | A, B | UTP | 6 (best 0.76) |
| 5W0O | Structure of human TUT7 catalytic module (cm) in complex with dsrna | x-ray diffraction | A, B | UTP | — |
| 8OEF | Structure of human terminal uridylyltransferase 7 (hTUT7/ZCCHC6) | electron microscopy | A | — | 8 (best 0.70) |
| 8OPP | Structure of human terminal uridylyltransferase 7 (hTUT7/ZCCHC6) bound with pre-let7g miRNA and… | electron microscopy | A | P5E | 6 (best 0.81) |
| 8OPS | Human terminal uridylyltransferase 7 (TUT7/ZCCHC6) bound with pre-let7g miRNA and Lin28A - complex 1 | electron microscopy | A | — | 7 (best 0.65) |
| 8OPT | Human terminal uridylyltransferase 7 (TUT7/ZCCHC6) bound with pre-let7g miRNA and Lin28A - complex 2 | electron microscopy | A | ZN | 11 (best 0.74) |
| Q5VYS8 | AlphaFold monomer V2.0 prediction for terminal uridylyltransferase 7 (Q5VYS8) | predicted | A | — | 10 (best 0.80) |
Ligands
- ZN · Zinc ion · in 7 records
- IOD · Iodide ion · in 6 records
- SO4 · Sulfate ion · in 6 records
- 2KH · 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine · in 2 records
- MG · Magnesium ion · in 2 records
- UPU · [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S, 4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl hydrogen (S)-phosphate · in 2 records
- UTP · Uridine 5'-triphosphate · in 2 records
- P5E · [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene) pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl] phosphono hydrogen phosphate · in 1 record
Experiment against prediction
- 5W0N chain A against the predicted model Q5VYS8: TM-score 1.00, RMSD 0.26 Å
- 5W0N chain A against the predicted model Q5VYS8: TM-score 1.00, RMSD 0.26 Å
- 5W0M chain A against the predicted model Q5VYS8: TM-score 1.00, RMSD 0.29 Å
- 5W0M chain A against the predicted model Q5VYS8: TM-score 1.00, RMSD 0.29 Å
- 5W0M chain C against the predicted model Q5VYS8: TM-score 0.99, RMSD 0.67 Å
- 5W0M chain C against the predicted model Q5VYS8: TM-score 0.99, RMSD 0.67 Å
- 5W0N chain B against the predicted model Q5VYS8: TM-score 0.99, RMSD 0.72 Å
- 5W0N chain B against the predicted model Q5VYS8: TM-score 0.99, RMSD 0.72 Å
- 5W0B chain B against the predicted model Q5VYS8: TM-score 0.99, RMSD 0.72 Å
- 5W0B chain B against the predicted model Q5VYS8: TM-score 0.99, RMSD 0.72 Å
Elsewhere
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