MolNFT v1 · #137816 · protein
Structure of human TUT7 catalytic module (cm)
5W0B · Terminal uridylyltransferase 7: “Structure of human TUT7 catalytic module (cm)”. X-ray diffraction, 3 ligands (ZN, SO4, IOD), 16 pockets (best druggability 0.74). MolNFT v1 #137816 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5W0B
- Type
- protein
- Length
- 1,036 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Terminal uridylyltransferase 7
- EC
- 2.7.7.52
- UniProt
- Q5VYS8
- Ligands
- ZN, SO4, IOD
- Pockets
- 16 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 44% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Terminal uridylyltransferase 7 (EC 2.7.7.52) | protein | 334 | 44% helix, 12% strand | Q5VYS8 |
| B | Terminal uridylyltransferase 7 (EC 2.7.7.52) | protein | 349 | 44% helix, 13% strand | Q5VYS8 |
| C | Terminal uridylyltransferase 7 (EC 2.7.7.52) | protein | 353 | 45% helix, 13% strand | Q5VYS8 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
- SO4 · Sulfate ion · ion · 7 copies · chains A, B, C
- IOD · Iodide ion · ion · 3 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 339 | 0.74 | 0.86 | 54 | empty |
| 2 | 290 | 0.72 | 0.86 | 40 | SO4 |
| 3 | 758 | 0.72 | 0.78 | 82 | empty |
| 4 | 545 | 0.69 | 0.79 | 56 | empty |
| 5 | 502 | 0.65 | 0.77 | 52 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1024 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 936 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 815 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5VYS8
- Elsewhere: RCSB PDB 5W0B · PDBe 5W0B · UniProt Q5VYS8
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