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Ligand · UPU

UPU · [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S, 4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl hydrogen (S)-phosphate

UPU, [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S, 4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl hydrogen (S)-phosphate (C18…

Component
UPU
Formula
C18 H23 N4 O14 P
Class
ligand
Structures
2
PDB entries
1

Binding sites

UPU in 2 structures; the first of them:

  • 5W0N · Structure of human TUT7 catalytic module (CM) in complex with UMPNPP and U2 RNA · UPU A1403 · binds PHE1045, ASP1058, ASP1060, ILE1099, THR1101, ALA1102, VAL1104, ILE1106 and 12 more
  • 5W0N · Structure of human TUT7 catalytic module (cm) in complex with umpnpp and U2 RNA · UPU A1403 · binds PHE1045, ASP1058, ASP1060, ILE1099, ALA1102, VAL1104, ILE1106, ASP1119 and 7 more

Residues it binds most

ASP 6, ILE 6, ALA 6, SER 6, ASN 6, PHE 6, VAL 6, HIS 4, THR 5, GLY 4 (residue and the binding sites it lines).

Found with

  • 2KH · 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine
  • MG · Magnesium ion
  • ZN · Zinc ion
  • IOD · Iodide ion
  • SO4 · Sulfate ion

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