UniProt Q5V8Y6
RNA-directed RNA polymerase catalytic subunit (Q5V8Y6)
RNA-directed RNA polymerase catalytic subunit (UniProt Q5V8Y6), EC 2.7.7.48: 44 experimental structures on GenesisL1, 5 ligands bound, 422 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q5V8Y6
- Protein
- RNA-directed RNA polymerase catalytic subunit
- EC
- 2.7.7.48
- Experimental structures
- 44
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 422 · 28 records with a druggable one
Structures
44 records of Q5V8Y6 in the MolNFT archive: 44 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WRT | Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2) | x-ray diffraction | B | — | — |
| 4WRT | Crystal structure of influenza B polymerase with bound vrna promoter (form FLUB2) | x-ray diffraction | B | — | — |
| 4WSA | Crystal structure of Influenza B polymerase bound to the vRNA promoter (FluB1 form) | x-ray diffraction | B | — | — |
| 4WSA | Crystal structure of influenza B polymerase bound to the vrna promoter (FLUB1 form) | x-ray diffraction | B | — | — |
| 5EPI | Crystal structure of influenza B polymerase with bound 5' crna exhibits a novel domain arrangement | x-ray diffraction | B, F, J, N, R, V | — | — |
| 5FMZ | Crystal structure of Influenza B polymerase with bound 5' vRNA | x-ray diffraction | B, E | — | — |
| 5FMZ | Crystal structure of influenza B polymerase with bound 5' vrna | x-ray diffraction | B, E | — | — |
| 5M3J | Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD | x-ray diffraction | B | — | 14 (best 0.89) |
| 5M3J | Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated pol II ctd | x-ray diffraction | B | — | — |
| 5MSG | Influenza B polymerase bound to vRNA promoter and capped RNA primer | x-ray diffraction | B | PO4 | 16 (best 0.89) |
| 5MSG | Influenza B polymerase bound to vrna promoter and capped RNA primer | x-ray diffraction | B | PO4 | — |
| 6F5O | A mechanism for the activation of the influenza virus transcriptase | electron microscopy | B | — | 14 (best 0.88) |
| 6F5O | A mechanism for the activation of the influenza virus transcriptase | electron microscopy | B | — | — |
| 6QCS | Influenza B polymerase pre-initiation complex | electron microscopy | B | MG | 14 (best 0.89) |
| 6QCS | Influenza B polymerase pre-initiation complex | electron microscopy | B | MG | — |
| 6QCT | Influenza B polymerase elongation complex | electron microscopy | B | MG | 16 (best 0.86) |
| 6QCT | Influenza B polymerase elongation complex | electron microscopy | B | MG | — |
| 6QCV | Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP | x-ray diffraction | B | CTP, MG | 14 (best 0.90) |
| 6QCV | Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP | x-ray diffraction | B | CTP, MG | — |
| 6QCW | Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer | x-ray diffraction | B | PO4 | 15 (best 0.90) |
| 6QCW | Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer | x-ray diffraction | B | PO4 | — |
| 6QCX | Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer | x-ray diffraction | B | POP, MG | 16 (best 0.90) |
| 6QCX | Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer | x-ray diffraction | B | POP, MG | — |
| 6T0W | Human Influenza B polymerase recycling complex | electron microscopy | B | — | 17 (best 0.78) |
| 6T0W | Human influenza B polymerase recycling complex | electron microscopy | B | — | — |
| 7R1F | Early transcription elongation state of influenza B polymerase backtracked due to double… | electron microscopy | B | MG | 14 (best 0.91) |
| 7Z42 | Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B | x-ray diffraction | B, E | — | 16 (best 0.88) |
| 7Z42 | Influenza B polymerase with pol II PSER5 ctd peptide mimic bound in site 2B | x-ray diffraction | B, E | — | 16 (best 0.88) |
| 7Z43 | Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B | x-ray diffraction | BBB | PO4 | 15 (best 0.89) |
| 8BDR | Early transcription elongation state of influenza B/Mem polymerase backtracked due to double… | electron microscopy | B | MG | 16 (best 0.90) |
| 8BE0 | Early transcription elongation state of influenza B/Mem polymerase backtracked due to double… | electron microscopy | B | MG | 15 (best 0.89) |
| 8BF5 | Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP… | electron microscopy | B | G2P, MG | 16 (best 0.86) |
| 8RN1 | Influenza B polymerase, monomeric encapsidase with 5' cRNA hook bound | electron microscopy | B | — | 12 (best 0.85) |
| 8RN2 | Monomeric apo-influenza B polymerase, encapsidase conformation | electron microscopy | B | — | 14 (best 0.84) |
| 8RN3 | Pseudo-symmetrical influenza B polymerase apo-dimer, encapsidase moiety (from "Influenza B… | electron microscopy | B, E | MG | 15 (best 0.85) |
| 8RN4 | Pseudo-symmetrical influenza B polymerase apo-dimer, ENDO(T) moiety (from "Influenza B polymerase… | electron microscopy | B, E | MG | 16 (best 0.79) |
| 8RN5 | Pseudo-symmetrical influenza B polymerase apo-dimer, ENDO(R) moiety (from "Influenza B polymerase… | electron microscopy | B, D | MG | 19 (best 0.84) |
| 8RN6 | Pseudo-symmetrical influenza B polymerase apo-dimer, ENDO(E) moiety (from "Influenza B polymerase… | electron microscopy | B | — | 13 (best 0.80) |
| 8RN7 | Pseudo-symmetrical influenza B polymerase apo-dimer, core-only moeity (from "Influenza B polymerase… | electron microscopy | B, D | MG | 17 (best 0.80) |
| 8RN8 | Influenza B polymerase pseudo-symmetrical apo-dimer (FluPol(E)|FluPol(S)) | electron microscopy | B, E | MG | 17 (best 0.83) |
| 8RN9 | Influenza B polymerase, replicase (from "Influenza B polymerase apo-trimer" | Local refinement) | electron microscopy | B, D | — | 14 (best 0.81) |
| 8RNA | Influenza B polymerase apo-trimer | electron microscopy | B, E, Y | — | 15 (best 0.86) |
| 8RNB | Influenza B polymerase, encapsidase plus 627(R) / human ANP32A (from "Influenza B polymerase… | electron microscopy | E | — | 12 (best 0.85) |
| 8RNC | Influenza B polymerase, replication complex, an asymmetric polymerase dimer bound to human ANP32A… | electron microscopy | B, Y, E | — | 14 (best 0.86) |
Ligands
Elsewhere
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