MolNFT v1 · #109081 · protein + RNA

Crystal structure of influenza B polymerase with bound vrna promoter (form FLUB2)

4WRT · Influenza virus polymerase vrna promoter 3' end: “Crystal structure of influenza B polymerase with bound vrna promoter (form FLUB2)”. X-ray diffraction, 20 pockets (best druggability 0.82). MolNFT v1 #109081 on GenesisL1: 3D…

PDB: 4WRT
Type: protein + RNA
Length: 1,730 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Influenza virus polymerase vrna promoter 3' end; Influenza virus polymerase vrna promoter…
EC: 2.7.7.48
UniProt: Q5V8Z9, Q5V8Y6, Q5V8X3
Pockets: 20 · best druggability 0.82

Structure

x-ray diffraction · 5 distinct chains · 46% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R	Influenza virus polymerase vrna promoter 3' end	rna	15	—	—
V	Influenza virus polymerase vrna promoter 5' end	rna	14	—	—
A	Pa	protein	709	46% helix, 17% strand	Q5V8Z9
B	RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48)	protein	742	47% helix, 16% strand	Q5V8Y6
C	PB2	protein	250	46% helix, 19% strand	Q5V8X3

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	706	0.82	0.86	73	empty
2	985	0.78	0.80	82	empty
3	432	0.78	0.87	49	empty
4	579	0.77	0.84	77	empty
5	817	0.76	0.80	86	empty

Interfaces

9 interfaces between chains.

A–B · 8966 Å² buried · 148 hydrogen bonds · protein-protein
B–C · 6336 Å² buried · 75 hydrogen bonds · protein-protein
A–C · 1402 Å² buried · 14 hydrogen bonds · protein-protein
V–A · 1261 Å² buried · 19 hydrogen bonds · protein-nucleic
R–B · 989 Å² buried · 26 hydrogen bonds · protein-nucleic

Compared structures

4WRT · Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2) · the same entry in another collection · chain R against R, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5V8Z9
Every structure of UniProt Q5V8Y6
Every structure of UniProt Q5V8X3
Elsewhere: RCSB PDB 4WRT · PDBe 4WRT · UniProt Q5V8Z9 · UniProt Q5V8Y6 · UniProt Q5V8X3

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