UniProt Q5V8X3
Polymerase basic protein 2 (Q5V8X3)
Polymerase basic protein 2 (UniProt Q5V8X3): 46 experimental structures on GenesisL1, 4 ligands bound, 377 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q5V8X3
- Protein
- Polymerase basic protein 2
- Experimental structures
- 46
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 377 · 28 records with a druggable one
Structures
46 records of Q5V8X3 in the MolNFT archive: 46 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WRT | Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2) | x-ray diffraction | C | — | — |
| 4WRT | Crystal structure of influenza B polymerase with bound vrna promoter (form FLUB2) | x-ray diffraction | C | — | — |
| 4WSA | Crystal structure of Influenza B polymerase bound to the vRNA promoter (FluB1 form) | x-ray diffraction | C | — | — |
| 4WSA | Crystal structure of influenza B polymerase bound to the vrna promoter (FLUB1 form) | x-ray diffraction | C | — | — |
| 5EPI | Crystal structure of influenza B polymerase with bound 5' crna exhibits a novel domain arrangement | x-ray diffraction | C, G, K, O, S, W | — | — |
| 5FML | Crystal structure of the endonuclease from the PA subunit of influenza B virus bound to the PB2… | x-ray diffraction | A | — | — |
| 5FML | Crystal structure of the endonuclease from the pa subunit of influenza B virus bound to the PB2… | x-ray diffraction | A | — | — |
| 5FMZ | Crystal structure of Influenza B polymerase with bound 5' vRNA | x-ray diffraction | C, F | — | — |
| 5FMZ | Crystal structure of influenza B polymerase with bound 5' vrna | x-ray diffraction | C, F | — | — |
| 5M3J | Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD | x-ray diffraction | C | — | 15 (best 0.89) |
| 5M3J | Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated pol II ctd | x-ray diffraction | C | — | — |
| 5MSG | Influenza B polymerase bound to vRNA promoter and capped RNA primer | x-ray diffraction | C | — | 15 (best 0.89) |
| 5MSG | Influenza B polymerase bound to vrna promoter and capped RNA primer | x-ray diffraction | C | — | — |
| 6EUX | Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound… | x-ray diffraction | A | BYB | 2 (best 0.65) |
| 6EUX | Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound… | x-ray diffraction | A | BYB | — |
| 6F5O | A mechanism for the activation of the influenza virus transcriptase | electron microscopy | C | — | 14 (best 0.88) |
| 6F5O | A mechanism for the activation of the influenza virus transcriptase | electron microscopy | C | — | — |
| 6QCS | Influenza B polymerase pre-initiation complex | electron microscopy | C | — | 14 (best 0.89) |
| 6QCS | Influenza B polymerase pre-initiation complex | electron microscopy | C | GTG | — |
| 6QCT | Influenza B polymerase elongation complex | electron microscopy | C | — | 14 (best 0.86) |
| 6QCT | Influenza B polymerase elongation complex | electron microscopy | C | GTG | — |
| 6QCV | Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP | x-ray diffraction | C | — | 17 (best 0.90) |
| 6QCV | Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP | x-ray diffraction | C | — | — |
| 6QCW | Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer | x-ray diffraction | C | — | 16 (best 0.90) |
| 6QCW | Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer | x-ray diffraction | C | — | — |
| 6QCX | Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer | x-ray diffraction | C | — | 16 (best 0.90) |
| 6QCX | Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer | x-ray diffraction | C | — | — |
| 7R1F | Early transcription elongation state of influenza B polymerase backtracked due to double… | electron microscopy | C | GTA | 15 (best 0.91) |
| 7Z42 | Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B | x-ray diffraction | C, F | — | 16 (best 0.88) |
| 7Z42 | Influenza B polymerase with pol II PSER5 ctd peptide mimic bound in site 2B | x-ray diffraction | C, F | — | 16 (best 0.88) |
| 7Z43 | Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B | x-ray diffraction | CCC | IC5 | 16 (best 0.89) |
| 8BDR | Early transcription elongation state of influenza B/Mem polymerase backtracked due to double… | electron microscopy | C | GTA | 14 (best 0.90) |
| 8BE0 | Early transcription elongation state of influenza B/Mem polymerase backtracked due to double… | electron microscopy | C | GTA | 12 (best 0.89) |
| 8BF5 | Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP… | electron microscopy | C | GTA | 15 (best 0.86) |
| 8RN1 | Influenza B polymerase, monomeric encapsidase with 5' cRNA hook bound | electron microscopy | C | — | 14 (best 0.85) |
| 8RN2 | Monomeric apo-influenza B polymerase, encapsidase conformation | electron microscopy | C | — | 11 (best 0.84) |
| 8RN3 | Pseudo-symmetrical influenza B polymerase apo-dimer, encapsidase moiety (from "Influenza B… | electron microscopy | C | — | 10 (best 0.85) |
| 8RN4 | Pseudo-symmetrical influenza B polymerase apo-dimer, ENDO(T) moiety (from "Influenza B polymerase… | electron microscopy | C | — | 10 (best 0.79) |
| 8RN5 | Pseudo-symmetrical influenza B polymerase apo-dimer, ENDO(R) moiety (from "Influenza B polymerase… | electron microscopy | C | — | 14 (best 0.84) |
| 8RN6 | Pseudo-symmetrical influenza B polymerase apo-dimer, ENDO(E) moiety (from "Influenza B polymerase… | electron microscopy | C | — | 5 (best 0.78) |
| 8RN7 | Pseudo-symmetrical influenza B polymerase apo-dimer, core-only moeity (from "Influenza B polymerase… | electron microscopy | C | — | 11 (best 0.80) |
| 8RN8 | Influenza B polymerase pseudo-symmetrical apo-dimer (FluPol(E)|FluPol(S)) | electron microscopy | C, F | — | 13 (best 0.82) |
| 8RN9 | Influenza B polymerase, replicase (from "Influenza B polymerase apo-trimer" | Local refinement) | electron microscopy | C | — | 17 (best 0.82) |
| 8RNA | Influenza B polymerase apo-trimer | electron microscopy | C, F, Z | — | 14 (best 0.87) |
| 8RNB | Influenza B polymerase, encapsidase plus 627(R) / human ANP32A (from "Influenza B polymerase… | electron microscopy | F, C | — | 14 (best 0.85) |
| 8RNC | Influenza B polymerase, replication complex, an asymmetric polymerase dimer bound to human ANP32A… | electron microscopy | C, F | — | 17 (best 0.86) |
Ligands
- GTA · P1-7-methylguanosine-P3-adenosine-5',5'-triphosphate · in 4 records
- BYB · (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid · in 2 records
- GTG · 7-methyl-guanosine-5'-triphosphate-5'-guanosine · in 2 records
- IC5 · [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate · in 1 record
Elsewhere
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