UniProt Q5SI56
Serine hydroxymethyltransferase (Q5SI56)
Serine hydroxymethyltransferase (UniProt Q5SI56), EC 2.1.2.1: 6 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 41 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q5SI56
- Protein
- Serine hydroxymethyltransferase
- EC
- 2.1.2.1
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 41 · 6 records with a druggable one
Structures
7 records of Q5SI56 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8SSY | Room-temperature X-ray structure of Thermus thermophilus serine hydroxymethyltransferase (SHMT)… | x-ray diffraction | A, B | DSN, SO4 | 7 (best 0.70) |
| 8SUI | Joint X-ray/neutron structure of Thermus thermophilus serine hydroxymethyltransferase (TthSHMT) in… | x-ray diffraction, neutron diffraction | A, B | SO4, SER | 7 (best 0.71) |
| 8SUJ | Joint X-ray/neutron structure of Thermus thermophilus serine hydroxymethyltransferase (TthSHMT) in… | x-ray diffraction, neutron diffraction | A, B | SO4 | 9 (best 0.70) |
| 9BOH | Room-temperature X-ray structure of Thermus Thermophilus serine hydroxymethyltransferase (SHMT)… | x-ray diffraction | A, B | SO4, A1AQW, FFO | 6 (best 0.75) |
| 9BOW | X-ray structure of Thermus thermophilus serine hydroxymethyltransferase with PLP-L-Ser external… | x-ray diffraction | A, B | SER, SO4, KOU, FFO | 6 (best 0.75) |
| 9BPE | Joint X-ray/neutron structure of Thermus thermophilus serine hydroxymethyltransferase (TthSHMT) in… | x-ray diffraction, neutron diffraction | A, B | SO4, FFO | 6 (best 0.74) |
| Q5SI56 | AlphaFold monomer V2.0 prediction for serine hydroxymethyltransferase (Q5SI56) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 6 records
- FFO · N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid · in 3 records
- SER · Serine · in 2 records
- A1AQW · (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)glycine · in 1 record
- DSN · D-serine · in 1 record
- KOU · (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine · in 1 record
Experiment against prediction
- 8SSY chain B against the predicted model Q5SI56: TM-score 1.00, RMSD 0.39 Å
- 8SUI chain B against the predicted model Q5SI56: TM-score 1.00, RMSD 0.44 Å
- 8SUJ chain B against the predicted model Q5SI56: TM-score 1.00, RMSD 0.45 Å
- 9BOW chain A against the predicted model Q5SI56: TM-score 0.99, RMSD 0.52 Å
- 8SUJ chain A against the predicted model Q5SI56: TM-score 0.99, RMSD 0.52 Å
- 8SUI chain A against the predicted model Q5SI56: TM-score 0.99, RMSD 0.53 Å
- 9BPE chain A against the predicted model Q5SI56: TM-score 0.99, RMSD 0.53 Å
- 8SSY chain A against the predicted model Q5SI56: TM-score 0.99, RMSD 0.53 Å
- 9BOH chain B against the predicted model Q5SI56: TM-score 0.99, RMSD 0.57 Å
- 9BPE chain B against the predicted model Q5SI56: TM-score 0.99, RMSD 0.59 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.