UniProt Q5S007
Leucine-rich repeat serine/threonine-protein kinase 2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (UniProt Q5S007), EC 2.7.11.1, 3.6.5.-: 26 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 108 pockets. Binding sites, druggability and experiment…
- UniProt
- Q5S007
- Protein
- Leucine-rich repeat serine/threonine-protein kinase 2
- EC
- 2.7.11.1, 3.6.5.-
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 108 · 7 records with a druggable one
Structures
27 records of Q5S007 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3D6T | Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2… | x-ray diffraction | B | — | — |
| 3D6T | Structure of the roc domain from the PARKINSON'S disease-associated leucine-rich repeat kinase 2… | x-ray diffraction | B | — | — |
| 5MY9 | Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS935 | x-ray diffraction | P | — | — |
| 5MY9 | Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide PS935 | x-ray diffraction | P | — | — |
| 5MYC | Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide PS910 | x-ray diffraction | P | — | — |
| 6DLO | Crystal structure of LRRK2 WD40 domain dimer | x-ray diffraction | B, A | — | — |
| 6DLP | Crystal structure of LRRK2 WD40 domain dimer | x-ray diffraction | B, A | PT | 5 (best 0.73) |
| 6DLP | Crystal structure of LRRK2 WD40 domain dimer | x-ray diffraction | B, A | PT | — |
| 6OJE | Dimeric structure of LRRK2 GTPase domain | x-ray diffraction | A, B | MG, GDP | — |
| 6OJF | Dimeric structure of LRRK2 GTPase domain | x-ray diffraction | A, B | MG, GDP | — |
| 6VNO | Cryo-EM structure of the C-terminal half of the PARKINSON'S disease- linked protein leucine rich… | electron microscopy | A | GDP, MG | — |
| 6VP6 | Cryo-EM structure of the C-terminal half of the Parkinson's Disease-linked protein Leucine Rich… | electron microscopy | A, B, C | GDP, MG | 20 (best 0.81) |
| 6VP6 | Cryo-EM structure of the C-terminal half of the PARKINSON'S disease- linked protein leucine rich… | electron microscopy | A, B, C | GDP, MG | — |
| 6VP7 | Cryo-EM structure of the C-terminal half of the PARKINSON'S disease- linked protein leucine rich… | electron microscopy | A | — | — |
| 6VP8 | Cryo-EM structure of the C-terminal half of the PARKINSON'S disease- linked protein leucine rich… | electron microscopy | A, B, C | — | — |
| 6XAF | 1.9A crystal structure of the GTPase domain of PARKINSON'S disease- associated protein LRRK2… | x-ray diffraction | A, B | MG, GDP | — |
| 6XR4 | Integrative in situ structure of parkinsons disease-linked human LRRK2 | electron microscopy | A, B | — | — |
| 7LHT | Structure of the LRRK2 dimer | electron microscopy | A, B | GDP, ATP | — |
| 7LHW | Structure of the LRRK2 monomer | electron microscopy | A | GDP, ATP | 20 (best 0.77) |
| 7LHW | Structure of the LRRK2 monomer | electron microscopy | A | GDP, ATP | — |
| 7LI3 | Structure of the LRRK2 G2019S mutant | electron microscopy | A | GDP, ATP | 20 (best 0.80) |
| 7LI3 | Structure of the LRRK2 G2019S mutant | electron microscopy | A | GDP, ATP | — |
| 7LI4 | Structure of LRRK2 after symmetry expansion | electron microscopy | A | GDP, ATP | — |
| 8FO2 | Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 monomer state | electron microscopy | E | GDP, ATP | 18 (best 0.81) |
| 9C76 | LRRK2 Roc domain RP (Ras-pocket) complexed to Divarasib | x-ray diffraction | A, B | GDP, BR, MG, F, A1AWR, IOD | 5 (best 0.71) |
| 9CHO | Autoinhibited full-length LRRK2(I2020T) on microtubules with MLi-2 | electron microscopy | A | GDP, A1N | 20 (best 0.82) |
| Q5S007 | AlphaFold monomer V2.0 prediction for leucine-rich repeat SERINE/THREONINE-protein kinase 2 (Q5S007) | predicted | A | — | — |
Ligands
- GDP · Guanosine-5'-diphosphate · in 15 records
- ATP · Adenosine-5'-triphosphate · in 7 records
- MG · Magnesium ion · in 7 records
- PT · Platinum (II) ion · in 2 records
- A1AWR · 1-{(3S)-4-[(7M)-7-[6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl]-6-chloro-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}quinazolin-4-yl]-3-methylpiperazin-1-yl}propan-1-one · in 1 record
- A1N · (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine · in 1 record
- BR · Bromide ion · in 1 record
- F · Fluoride ion · in 1 record
- IOD · Iodide ion · in 1 record
Experiment against prediction
- 6VP8 chain C against the predicted model Q5S007: TM-score 0.98, RMSD 0.85 Å
- 6VP6 chain C against the predicted model Q5S007: TM-score 0.98, RMSD 0.87 Å
- 6VP6 chain C against the predicted model Q5S007: TM-score 0.98, RMSD 0.87 Å
- 6DLP chain B against the predicted model Q5S007: TM-score 0.98, RMSD 1.10 Å
- 6DLP chain B against the predicted model Q5S007: TM-score 0.98, RMSD 1.10 Å
- 6DLO chain B against the predicted model Q5S007: TM-score 0.98, RMSD 1.10 Å
- 6DLP chain A against the predicted model Q5S007: TM-score 0.98, RMSD 1.12 Å
- 6DLP chain A against the predicted model Q5S007: TM-score 0.98, RMSD 1.12 Å
- 6DLO chain A against the predicted model Q5S007: TM-score 0.98, RMSD 1.12 Å
- 5MY9 chain P against the predicted model Q5S007: TM-score 0.97, RMSD 0.08 Å
Elsewhere
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