UniProt Q4VCS5

Amot-p130 phosphopeptide (pS175) (Q4VCS5)

Amot-p130 phosphopeptide (pS175) (UniProt Q4VCS5), EC 2.3.2.26: 36 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: Q4VCS5
Protein: Amot-p130 phosphopeptide (pS175)
EC: 2.3.2.26
Experimental structures: 36
Predicted models: 1
Ligands: 7
Pockets: 54 · 12 records with a druggable one

Structures

37 records of Q4VCS5 in the MolNFT archive: 36 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6JJX	Crystal Structure of KIBRA and Angiomotin complex	x-ray diffraction	D, C	—	—
6JJX	Crystal structure of kibra and angiomotin complex	x-ray diffraction	D, C	—	—
7LP2	Structure of Nedd4L WW3 domain	x-ray diffraction	B, D, F	SO4	1 (best 0.65)
7LP2	Structure of NEDD4L WW3 domain	x-ray diffraction	B, D, F	SO4	1 (best 0.65)
7LP3	Structure of Nedd4L WW3 domain	x-ray diffraction	B, D	SO4	—
7LP3	Structure of NEDD4L WW3 domain	x-ray diffraction	B, D	SO4	—
7LP5	Structure of Nedd4L WW3 domain	solution nmr	A	—	—
7LP5	Structure of NEDD4L WW3 domain	solution nmr	A	—	—
7NMA	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide	x-ray diffraction	P	—	2 (best 0.49)
7NMA	Crystal structure of 14-3-3 sigma in complex with 13MER amot-P130 peptide	x-ray diffraction	P	—	2 (best 0.49)
7NMW	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 40	x-ray diffraction	P	—	2 (best 0.53)
7NMW	Crystal structure of 14-3-3 sigma in complex with 13MER amot-P130 peptide and fragment 40	x-ray diffraction	P	—	2 (best 0.53)
7NMX	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 12	x-ray diffraction	P	—	2 (best 0.43)
7NMX	Crystal structure of 14-3-3 sigma in complex with 13MER amot-P130 peptide and fragment 12	x-ray diffraction	P	—	2 (best 0.43)
7NN2	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 41	x-ray diffraction	P	K8W	2 (best 0.53)
7NN2	Crystal structure of 14-3-3 sigma in complex with 13MER amot-P130 peptide and fragment 41	x-ray diffraction	P	K8W	2 (best 0.53)
7NND	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 09	x-ray diffraction	P	K7N	2 (best 0.62)
7NND	Crystal structure of 14-3-3 sigma in complex with 13MER amot-P130 peptide and fragment 09	x-ray diffraction	P	K7N	2 (best 0.62)
7NNE	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 22	x-ray diffraction	P	K92	2 (best 0.57)
7NNE	Crystal structure of 14-3-3 sigma in complex with 13MER amot-P130 peptide and fragment 22	x-ray diffraction	P	K92	2 (best 0.57)
7NP2	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide	x-ray diffraction	P	—	2 (best 0.42)
7NP2	Crystal structure of 14-3-3 sigma in complex with 20MER amot-P130 peptide	x-ray diffraction	P	—	2 (best 0.42)
7NPB	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 09	x-ray diffraction	P	K7N	2 (best 0.61)
7NPB	Crystal structure of 14-3-3 sigma in complex with 20MER amot-P130 peptide and fragment 09	x-ray diffraction	P	K7N	2 (best 0.61)
7NPG	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 22	x-ray diffraction	P	K92	1 (best 0.47)
7NPG	Crystal structure of 14-3-3 sigma in complex with 20MER amot-P130 peptide and fragment 22	x-ray diffraction	P	K92	1 (best 0.47)
7OQG	Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ136	x-ray diffraction	P	0AW	2 (best 0.47)
7OQG	Ternary complex of 14-3-3 sigma, amot-P130 phosphopeptide, and WQ136	x-ray diffraction	P	0AW	2 (best 0.47)
7OQJ	Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ162	x-ray diffraction	P	09W	2 (best 0.40)
7OQJ	Ternary complex of 14-3-3 sigma, amot-P130 phosphopeptide, and WQ162	x-ray diffraction	P	09W	2 (best 0.40)
7OQS	Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ177	x-ray diffraction	P	0BS	2 (best 0.50)
7OQS	Ternary complex of 14-3-3 sigma, amot-P130 phosphopeptide, and WQ177	x-ray diffraction	P	0BS	2 (best 0.50)
7OQU	Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ180	x-ray diffraction	P	—	2 (best 0.45)
7OQU	Ternary complex of 14-3-3 sigma, amot-P130 phosphopeptide, and WQ180	x-ray diffraction	P	—	2 (best 0.45)
7OQW	Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ178	x-ray diffraction	P	—	1 (best 0.40)
7OQW	Ternary complex of 14-3-3 sigma, amot-P130 phosphopeptide, and WQ178	x-ray diffraction	P	—	1 (best 0.40)
Q4VCS5	AlphaFold monomer V2.0 prediction for angiomotin (Q4VCS5)	predicted	A	—	—

Ligands

K7N · 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide · in 4 records
K92 · 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide · in 4 records
SO4 · Sulfate ion · in 4 records
09W · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-7-carboxamide · in 2 records
0AW · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-5-carboxamide · in 2 records
0BS · 2-(1,3-benzodioxol-5-yl)-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]ethanamide · in 2 records
K8W · 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide · in 2 records

Experiment against prediction

7OQW chain P against the predicted model Q4VCS5: TM-score 0.62, RMSD 0.60 Å
7OQW chain P against the predicted model Q4VCS5: TM-score 0.62, RMSD 0.60 Å
7OQU chain P against the predicted model Q4VCS5: TM-score 0.57, RMSD 0.57 Å
7OQU chain P against the predicted model Q4VCS5: TM-score 0.57, RMSD 0.57 Å
7NN2 chain P against the predicted model Q4VCS5: TM-score 0.57, RMSD 0.84 Å
7NN2 chain P against the predicted model Q4VCS5: TM-score 0.57, RMSD 0.84 Å
7OQS chain P against the predicted model Q4VCS5: TM-score 0.54, RMSD 1.07 Å
7OQS chain P against the predicted model Q4VCS5: TM-score 0.54, RMSD 1.07 Å
7NMW chain P against the predicted model Q4VCS5: TM-score 0.53, RMSD 0.82 Å
7NMW chain P against the predicted model Q4VCS5: TM-score 0.53, RMSD 0.82 Å

Elsewhere

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