MolNFT v1 · #183339 · protein
Crystal structure of 14-3-3 sigma in complex with 13MER amot-P130 peptide
7NMA · 14-3-3 protein sigma: “Crystal structure of 14-3-3 sigma in complex with 13MER amot-P130 peptide”. X-ray diffraction, 2 ligands (MG, CL), 2 pockets (best druggability 0.49). MolNFT v1 #183339 on GenesisL1: 3D structure, binding…
- PDB
- 7NMA
- Type
- protein
- Length
- 240 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein sigma; Amot-P130 phosphopeptide (PS175)
- UniProt
- P31947, Q4VCS5
- Ligands
- MG, CL
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein sigma | protein | 232 | 81% helix, 0% strand | P31947 |
| P | Amot-P130 phosphopeptide (PS175) | protein | 8 | 0% helix, 0% strand | Q4VCS5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.49 | 0.79 | 25 | empty |
| 2 | 97 | 0.36 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–P · 654 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation, phosphorylation).
Compared structures
- 7NMA · Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q4VCS5 · AlphaFold monomer V2.0 prediction for angiomotin (Q4VCS5) · a predicted model of the same protein · chain P against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31947
- Every structure of UniProt Q4VCS5
- Elsewhere: RCSB PDB 7NMA · PDBe 7NMA · UniProt P31947 · UniProt Q4VCS5
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