UniProt P31947
14-3-3 protein sigma (P31947)
14-3-3 protein sigma (UniProt P31947): 652 experimental structures and 1 predicted model on GenesisL1, 243 ligands bound, 433 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P31947
- Protein
- 14-3-3 protein sigma
- Experimental structures
- 652
- Predicted models
- 1
- Ligands
- 243
- Pockets
- 433 · 138 records with a druggable one
Structures
653 records of P31947 in the MolNFT archive: 652 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YWT | Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide | x-ray diffraction | A, B | — | — |
| 1YWT | Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide | x-ray diffraction | A, B | — | — |
| 1YZ5 | The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution | x-ray diffraction | A, B | — | — |
| 1YZ5 | The crystal structure of 14-3-3-sigma at 2.8 ångström resolution | x-ray diffraction | A, B | — | — |
| 3IQJ | Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer) | x-ray diffraction | A | — | — |
| 3IQJ | Crystal structure of human 14-3-3 sigma in complex with RAF1 peptide (10MER) | x-ray diffraction | A | — | — |
| 3IQU | Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) | x-ray diffraction | A | — | — |
| 3IQU | Crystal structure of human 14-3-3 sigma in complex with RAF1 peptide (6MER) | x-ray diffraction | A | — | — |
| 3IQV | Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator… | x-ray diffraction | A | — | — |
| 3IQV | Crystal structure of human 14-3-3 sigma in complex with RAF1 peptide (6MER) and stabilisator… | x-ray diffraction | A | — | — |
| 3LW1 | Binary complex of 14-3-3 sigma and p53 pT387-peptide | x-ray diffraction | A | — | — |
| 3LW1 | Binary complex of 14-3-3 sigma and P53 PT387-peptide | x-ray diffraction | A | — | — |
| 3MHR | 14-3-3 sigma in complex with YAP pS127-peptide | x-ray diffraction | A | — | — |
| 3MHR | 14-3-3 sigma in complex with yap PS127-peptide | x-ray diffraction | A | — | — |
| 3O8I | Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule… | x-ray diffraction | A | — | — |
| 3O8I | Structure of 14-3-3 isoform sigma in complex with a C-RAF1 peptide and a stabilizing small molecule… | x-ray diffraction | A | — | — |
| 3P1N | Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide | x-ray diffraction | A | — | — |
| 3P1N | Crystal structure of human 14-3-3 sigma in complex with task-3 peptide | x-ray diffraction | A | — | — |
| 3P1O | Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilisator Fusicoccin A | x-ray diffraction | A | — | — |
| 3P1O | Crystal structure of human 14-3-3 sigma in complex with task-3 peptide and stabilisator fusicoccin a | x-ray diffraction | A | — | — |
| 3P1P | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide | x-ray diffraction | A | — | — |
| 3P1P | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide | x-ray diffraction | A | — | — |
| 3P1Q | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 Peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3P1Q | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3P1R | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide | x-ray diffraction | A | — | — |
| 3P1R | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with task-3 peptide | x-ray diffraction | A | — | — |
| 3P1S | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3P1S | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SMK | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SMK | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SML | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SML | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SMM | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SMM | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SMN | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SMN | Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SMO | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SMO | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SP5 | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SP5 | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SPR | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3SPR | Crystal structure of human 14-3-3 sigma C38V/N166H in complex with task-3 peptide and stabilizer… | x-ray diffraction | A | — | — |
| 3T0L | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
| 3T0L | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
| 3T0M | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
| 3T0M | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
| 3U9X | Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins | x-ray diffraction | A | — | — |
| 3U9X | Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins | x-ray diffraction | A | — | — |
| 3UX0 | Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer Fusicoccin H | x-ray diffraction | A | — | — |
| 3UX0 | Crystal structure of human 14-3-3 sigma in complex with task-3 peptide and stabilizer fusicoccin H | x-ray diffraction | A | — | — |
| 4DAT | Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif II | x-ray diffraction | A | — | — |
| 4DAT | Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif II | x-ray diffraction | A | — | — |
| 4DAU | Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif I | x-ray diffraction | A | — | — |
| 4DAU | Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif I | x-ray diffraction | A | — | — |
| 4DHM | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
| 4DHM | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
| 4DHN | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
| 4DHN | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
| 4DHO | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
| 4DHO | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | x-ray diffraction | A | — | — |
593 records more on the page itself.
Ligands
- MG · Magnesium ion · in 318 records
- CL · Chloride ion · in 310 records
- CA · Calcium ion · in 131 records
- NA · Sodium ion · in 47 records
- FSC · Fusicoccin · in 17 records
- 0AW · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-5-carboxamide · in 10 records
- SO4 · Sulfate ion · in 10 records
- 09W · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-7-carboxamide · in 9 records
- 0B7 · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-1~{H}-indole-6-carboxamide · in 7 records
- K7N · 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide · in 6 records
- 9SZ · C42 H32 O8 P2 · in 4 records
- FAR · Farnesyl · in 4 records
- GEH · 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl) propanamide · in 4 records
- HY5 · Fc-ncpc · in 4 records
- K5Z · 5-(3-azanylpropyl)-4-phenyl-thiophene-2-carboximidamide · in 4 records
- K7Q · ~{N}-(2-azanylethyl)-2-carbamimidoyl-7-methoxy-1-benzothiophene-4-carboxamide · in 4 records
- K8W · 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide · in 4 records
- K92 · 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide · in 4 records
- KDK · 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide · in 4 records
- L1T · 4-methyl-5-phenyl-thiophene-2-carboximidamide · in 4 records
- TJ8 · 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde · in 4 records
- 60H · (2~{S})-2-(diphenylmethyl)pyrrolidine · in 3 records
- EZ5 · ~{N}-[(2~{S})-2-[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R}, 11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-8-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(2-methylbut-3-en-2-yloxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,9-bis(oxidanyl)-6-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]propyl]ethanamide · in 3 records
- JT2 · 4-[[(2~{S})-1-azanylpropan-2-yl]amino]-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide · in 3 records
- K48 · 5-azanyl-4-phenyl-thiophene-2-carboximidamide · in 3 records
- KM8 · ~{N}-[3-(5-carbamimidoylthiophen-3-yl) phenyl]propanamide · in 3 records
- NH2 · Amino group · in 3 records
- P5N · 1-(4-methylphenyl)imidazole · in 3 records
- S9E · 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde · in 3 records
- 0BL · (2~{S},3~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-3-methyl-2,3-dihydro-1-benzofuran-2-carboxamide · in 2 records
Experiment against prediction
- 5LU2 chain A against the predicted model P31947: TM-score 0.99, RMSD 0.59 Å
- 5LU2 chain A against the predicted model P31947: TM-score 0.99, RMSD 0.59 Å
- 5LU1 chain A against the predicted model P31947: TM-score 0.99, RMSD 0.59 Å
- 5LU1 chain A against the predicted model P31947: TM-score 0.99, RMSD 0.59 Å
- 5LU2 chain B against the predicted model P31947: TM-score 0.99, RMSD 0.61 Å
- 5LU2 chain B against the predicted model P31947: TM-score 0.99, RMSD 0.61 Å
- 7QIK chain A against the predicted model P31947: TM-score 0.99, RMSD 0.79 Å
- 7QIK chain A against the predicted model P31947: TM-score 0.99, RMSD 0.79 Å
- 5LTW chain E against the predicted model P31947: TM-score 0.98, RMSD 0.94 Å
- 5LTW chain E against the predicted model P31947: TM-score 0.98, RMSD 0.94 Å
Elsewhere
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