UniProt Q2T9S0
Tubulin beta-3 chain (Q2T9S0)
Tubulin beta-3 chain (UniProt Q2T9S0): 4 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q2T9S0
- Protein
- Tubulin beta-3 chain
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 25 · 3 records with a druggable one
Structures
5 records of Q2T9S0 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7ALR | Crystal structure of TD1-gatorbulin1 complex | x-ray diffraction | B | GTP, MG, RQK, SO4, GDP | 9 (best 0.80) |
| 7ALR | Crystal structure of TD1-GATORBULIN1 complex | x-ray diffraction | B | GTP, MG, RQK, SO4, GDP | — |
| 7ODN | Crystal structure of TD1-mebendazole complex | x-ray diffraction | B | GTP, MG, SO4, GDP, V95, CL | 10 (best 0.82) |
| 7ODN | Crystal structure of TD1-mebendazole complex | x-ray diffraction | B | GTP, MG, SO4, GDP, V95, CL | — |
| Q2T9S0 | AlphaFold monomer V2.0 prediction for tubulin beta-3 chain (Q2T9S0) | predicted | A | — | 6 (best 0.59) |
Ligands
- GDP · Guanosine-5'-diphosphate · in 4 records
- GTP · Guanosine-5'-triphosphate · in 4 records
- MG · Magnesium ion · in 4 records
- SO4 · Sulfate ion · in 4 records
- CL · Chloride ion · in 2 records
- RQK · (2~{R})-2-oxidanyl-2-[(6~{S},9~{S},12~{S},15~{S}, 17~{S})-6,10,12,17-tetramethyl-3-methylidene-7-oxidanyl-2,5,8,11,14-pentakis(oxidanylidene)-13-oxa-1, 4,7,10-tetrazabicyclo[13.3.0]octadecan-9-yl]ethanamide · in 2 records
- V95 · methyl N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate · in 2 records
Experiment against prediction
- 7ODN chain B against the predicted model Q2T9S0: TM-score 0.98, RMSD 1.11 Å
- 7ODN chain B against the predicted model Q2T9S0: TM-score 0.98, RMSD 1.11 Å
- 7ALR chain B against the predicted model Q2T9S0: TM-score 0.98, RMSD 1.11 Å
- 7ALR chain B against the predicted model Q2T9S0: TM-score 0.98, RMSD 1.11 Å
Elsewhere
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