UniProt Q16552
Interleukin-17A (Q16552)
Interleukin-17A (UniProt Q16552): 33 experimental structures on GenesisL1, 6 ligands bound, 41 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q16552
- Protein
- Interleukin-17A
- Experimental structures
- 33
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 41 · 4 records with a druggable one
Structures
33 records of Q16552 in the MolNFT archive: 33 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VXS | Structure of IL-17A in complex with a potent, fully human neutralising antibody | x-ray diffraction | A, B, C, D | — | — |
| 2VXS | Structure of il-17A in complex with a potent, fully human neutralising antibody | x-ray diffraction | A, B, C, D | — | — |
| 4HR9 | Human interleukin 17A | x-ray diffraction | A, B | — | — |
| 4HR9 | Human interleukin 17A | x-ray diffraction | A, B | — | — |
| 4HSA | Structure of interleukin 17a in complex with il17ra receptor | x-ray diffraction | A, B, D, E | — | — |
| 4HSA | Structure of interleukin 17A in complex with IL17RA receptor | x-ray diffraction | A, B, D, E | — | — |
| 4QHU | Crystal Structure of IL-17A/Fab6785 complex | x-ray diffraction | C, D | — | — |
| 4QHU | Crystal structure of il-17A/FAB6785 complex | x-ray diffraction | C, D | — | — |
| 5HHV | Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide | x-ray diffraction | A, B | — | — |
| 5HHV | Inhibiting complex il-17A and il-17RA interactions with a linear peptide | x-ray diffraction | A, B | — | — |
| 5HHX | Inhibiting complex il-17A and il-17RA interactions with a linear peptide | x-ray diffraction | A, B | — | — |
| 5HI3 | Binding site elucidation and structure guided design of macrocyclic il-17A antagonists | x-ray diffraction | A, B | — | — |
| 5HI4 | Binding site elucidation and structure guided design of macrocyclic il-17A antagonists | x-ray diffraction | A, B | — | — |
| 5HI5 | Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists | x-ray diffraction | A, B | 63Q | — |
| 5HI5 | Binding site elucidation and structure guided design of macrocyclic il-17A antagonists | x-ray diffraction | A, B | — | — |
| 5N7W | Computationally designed functional antibody | x-ray diffraction | X, Y | — | — |
| 5N92 | Crystal structure of human il-17AF | x-ray diffraction | A | — | — |
| 5NAN | Crystal Structure of human IL-17AF in complex with human IL-17RA | x-ray diffraction | A, D | — | 12 (best 0.72) |
| 5NAN | Crystal structure of human il-17AF in complex with human il-17RA | x-ray diffraction | A, D | — | — |
| 5VB9 | Il-17A in complex with peptide | x-ray diffraction | A, B | CL | — |
| 6WIO | Fab antigen complex | x-ray diffraction | C | — | 1 (best 0.34) |
| 6WIO | Fab antigen complex | x-ray diffraction | C | — | — |
| 6WIR | Fab antigen complex | x-ray diffraction | C | — | — |
| 7AMA | Il-17A in complex with small molecule modulators | x-ray diffraction | A, B | RMK | — |
| 7AMG | Il-17A in complex with small molecule modulators | x-ray diffraction | A, B, C, D | RMQ | — |
| 7UWM | Structure of the IL-17A-IL-17RA binary complex | electron microscopy | A, B, D, E | — | 13 (best 0.77) |
| 7UWM | Structure of the il-17A-il-17RA binary complex | electron microscopy | A, B, D, E | — | — |
| 7UWN | Structure of the il-17A-il-17RA-il-17RC ternary complex | electron microscopy | A, B, D, E | NAG | — |
| 7WKX | Il-17A in complex with the humanized antibody HB0017 | x-ray diffraction | E, F | — | — |
| 7Z2M | Crystal Structure of the 11.003 Fab in complex with human IL-17A | x-ray diffraction | G, I, J, K | — | 12 (best 0.82) |
| 8CDG | Crystal structure of human IL-17A cytokine in complex with macrocycle | x-ray diffraction | A, B | — | — |
| 8DYG | IL17A homodimer bound to Compound 7 | x-ray diffraction | A, B | U5Q | 3 (best 0.68) |
| Q16552 | AlphaFold monomer V2.0 prediction for interleukin-17A (Q16552) | — | — | — |
Ligands
- 63Q · (4S,20R)-7-chloro-N-methyl-4-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-3,18-dioxo-2,19-diazatetracyclo[20.2.2.1~6,10~.1~11,15~]octacosa-1(24),6(28),7,9,11(27),12,14,22,25-nonaene-20-carboxamide · in 1 record
- CL · Chloride ion · in 1 record
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
- RMK · ~{N}-[(2~{S})-1,1-dicyclopropyl-3-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)phenyl]amino]-3-oxidanylidene-propan-2-yl]-2-propan-2-yl-pyrazole-3-carboxamide · in 1 record
- RMQ · (3~{R})-4-[4-[[(2~{S})-2-[[2,2-bis(fluoranyl)-2-phenyl-ethanoyl]amino]-3-(2-chlorophenyl) propanoyl]amino]phenyl]-3-[[(2~{S})-3-methyl-2-[2-[2-[(2-methylpropan-2-yl) oxycarbonylamino]ethoxy]ethanoylamino]butanoyl]amino]b utanoic acid · in 1 record
- U5Q · (5P)-2-hydroxy-5-(6-methylquinolin-5-yl)benzoic acid · in 1 record
Elsewhere
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