MolNFT v1 · #173035 · protein

Il-17A in complex with small molecule modulators

7AMA: “Il-17A in complex with small molecule modulators”. X-ray diffraction, 1 ligand (RMK). MolNFT v1 #173035 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7AMA
Type: protein
Length: 197 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q16552
Ligands: RMK

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	99	—	Q16552
B	—	protein	98	—	Q16552

Ligands and binding sites

RMK · ~{N}-[(2~{S})-1,1-dicyclopropyl-3-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)phenyl]amino]-3-oxidanylidene-propan-2-yl]-2-propan-2-yl-pyrazole-3-carboxamide · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7AMA · IL-17A in complex with small molecule modulators · the same entry in another collection · chain A against A, TM-score 1.00
Q16552 · AlphaFold monomer V2.0 prediction for interleukin-17A (Q16552) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16552
Elsewhere: RCSB PDB 7AMA · PDBe 7AMA · UniProt Q16552

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