Il-17A in complex with small molecule modulators

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• RMQ · (3~{R})-4-[4-[[(2~{S})-2-[[2,2-bis(fluoranyl)-2-phenyl-ethanoyl]amino]-3-(2-chlorophenyl) propanoyl]amino]phenyl]-3-[[(2~{S})-3-methyl-2-[2-[2-[(2-methylpropan-2-yl) oxycarbonylamino]ethoxy]ethanoylamino]butanoyl]amino]b utanoic acid · ligand · 2 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7AMG · IL-17A in complex with small molecule modulators · the same entry in another collection · chain D against D, TM-score 1.00
• Q16552 · AlphaFold monomer V2.0 prediction for interleukin-17A (Q16552) · a predicted model of the same protein · chain C against A, TM-score 0.89

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q16552
• Elsewhere: RCSB PDB 7AMG · PDBe 7AMG · UniProt Q16552