MolNFT v1 · #94256 · protein

Human interleukin 17A

4HR9 · Interleukin-17A: “Human interleukin 17A”. X-ray diffraction, 2 pockets (best druggability 0.68). MolNFT v1 #94256 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4HR9
Type: protein
Length: 189 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-17A
UniProt: Q16552
Pockets: 2 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 59% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-17A	protein	96	0% helix, 58% strand	Q16552
B	Interleukin-17A	protein	93	0% helix, 60% strand	Q16552

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	265	0.68	0.83	32	empty
2	125	0.49	0.79	18	empty

Interfaces

1 interface between chains.

A–B · 2287 Å² buried · 47 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4HR9 · Human interleukin 17A · the same entry in another collection · chain A against A, TM-score 1.00
Q16552 · AlphaFold monomer V2.0 prediction for interleukin-17A (Q16552) · a predicted model of the same protein · chain B against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16552
Elsewhere: RCSB PDB 4HR9 · PDBe 4HR9 · UniProt Q16552

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