UniProt Q14432
cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Q14432)
cGMP-inhibited 3',5'-cyclic phosphodiesterase A (UniProt Q14432), EC 3.1.4.17: 14 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 72 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q14432
- Protein
- cGMP-inhibited 3',5'-cyclic phosphodiesterase A
- EC
- 3.1.4.17
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 72 · 6 records with a druggable one
Structures
15 records of Q14432 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EG0 | Cryo-EM structure of anagrelide-induced PDE3A-SLFN12 complex | electron microscopy | A, C | J33, MG | 15 (best 0.83) |
| 7EG0 | Cryo-EM structure of anagrelide-induced PDE3A-SLFN12 complex | electron microscopy | A, C | J33, MG | — |
| 7EG1 | Cryo-EM structure of DNMDP-induced PDE3A-SLFN12 complex | electron microscopy | A, C | X5M, MG | 14 (best 0.83) |
| 7EG1 | Cryo-EM structure of dnmdp-induced PDE3A-SLFN12 complex | electron microscopy | A, C | X5M, MG | — |
| 7EG4 | Cryo-EM structure of nauclefine-induced PDE3A-SLFN12 complex | electron microscopy | C, A | J36, MG | — |
| 7KWE | Crystal structure of the catalytic domain of human PDE3A bound to dnmdp | x-ray diffraction | A, D, C, B | X5M, MN, MG | — |
| 7L27 | Crystal structure of the catalytic domain of human PDE3A | x-ray diffraction | A, B, C, D | MN, MG, CA | — |
| 7L28 | Crystal structure of the catalytic domain of human PDE3A bound to trequinsin | x-ray diffraction | A, B, C, D | XKG, MN, MG | — |
| 7L29 | Crystal structure of the catalytic domain of human PDE3A bound to AMP | x-ray diffraction | A, B, C, D | AMP, MN, MG, CA | 12 (best 0.79) |
| 7L29 | Crystal structure of the catalytic domain of human PDE3A bound to AMP | x-ray diffraction | A, B, C, D | AMP, MN, MG, CA | — |
| 7LRC | Cryo-EM of the SLFN12-PDE3A complex: PDE3A body refinement | electron microscopy | B, C | MN, MG, X5M | 9 (best 0.84) |
| 7LRC | Cryo-EM of the SLFN12-PDE3A complex: PDE3A body refinement | electron microscopy | B, C | MN, MG, X5M | — |
| 7LRD | Cryo-EM of the SLFN12-PDE3A complex: Consensus subset model | electron microscopy | B, D | MN, MG, X5M | 12 (best 0.84) |
| 7LRD | Cryo-EM of the SLFN12-PDE3A complex: consensus subset model | electron microscopy | B, D | MN, MG, X5M | — |
| Q14432 | AlphaFold monomer V2.0 prediction for cgmp-inhibited 3',5'-cyclic phosphodiesterase a (Q14432) | predicted | A | — | 10 (best 0.76) |
Ligands
- MG · Magnesium ion · in 14 records
- MN · Manganese (II) ion · in 9 records
- X5M · (4~{R})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{H}-pyridazin-6-one · in 7 records
- CA · Calcium ion · in 3 records
- AMP · Adenosine monophosphate · in 2 records
- J33 · 6,7-bis(chloranyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one · in 2 records
- J36 · Parvine · in 1 record
- XKG · (2E)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one · in 1 record
Experiment against prediction
- 7L28 chain A against the predicted model Q14432: TM-score 0.99, RMSD 0.52 Å
- 7KWE chain A against the predicted model Q14432: TM-score 0.99, RMSD 0.52 Å
- 7L27 chain B against the predicted model Q14432: TM-score 0.99, RMSD 0.54 Å
- 7KWE chain B against the predicted model Q14432: TM-score 0.99, RMSD 0.59 Å
- 7LRD chain B against the predicted model Q14432: TM-score 0.99, RMSD 0.59 Å
- 7LRD chain B against the predicted model Q14432: TM-score 0.99, RMSD 0.59 Å
- 7LRC chain C against the predicted model Q14432: TM-score 0.99, RMSD 0.59 Å
- 7LRC chain B against the predicted model Q14432: TM-score 0.99, RMSD 0.59 Å
- 7LRC chain B against the predicted model Q14432: TM-score 0.99, RMSD 0.59 Å
- 7LRD chain D against the predicted model Q14432: TM-score 0.99, RMSD 0.59 Å
Elsewhere
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