MolNFT v1 · #180517 · protein

Crystal structure of the catalytic domain of human PDE3A bound to trequinsin

7L28: “Crystal structure of the catalytic domain of human PDE3A bound to trequinsin”. X-ray diffraction, 3 ligands (XKG, MN, MG). MolNFT v1 #180517 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7L28
Type: protein
Length: 1,477 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q14432
Ligands: XKG, MN, MG

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	363	—	Q14432
B	—	protein	369	—	Q14432
C	—	protein	375	—	Q14432
D	—	protein	370	—	Q14432

Ligands and binding sites

XKG · (2E)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one · ligand · 4 copies · chains A, B, C, D
MN · Manganese (II) ion · metal · 4 copies · chains A, B, C, D
MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
ACT · Acetate ion · additive · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7L28 · Crystal structure of the catalytic domain of human PDE3A bound to Trequinsin · the same entry in another collection · chain D against D, TM-score 1.00
Q14432 · AlphaFold monomer V2.0 prediction for cgmp-inhibited 3',5'-cyclic phosphodiesterase a… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14432
Elsewhere: RCSB PDB 7L28 · PDBe 7L28 · UniProt Q14432

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