MolNFT v1 · #177357 · protein

Cryo-EM structure of anagrelide-induced PDE3A-SLFN12 complex

7EG0: “Cryo-EM structure of anagrelide-induced PDE3A-SLFN12 complex”. Electron microscopy, 3 ligands (J33, MG, ZN). MolNFT v1 #177357 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EG0
Type: protein
Length: 1,878 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q14432, Q8IYM2
Ligands: J33, MG, ZN

Structure

electron microscopy · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	—	protein	372	—	Q14432
B, D	—	protein	567	—	Q8IYM2

Ligands and binding sites

J33 · 6,7-bis(chloranyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one · ligand · 2 copies · chains A, C
MG · Magnesium ion · metal · 4 copies · chains A, C
ZN · Zinc ion · metal · 2 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7EG0 · Cryo-EM structure of anagrelide-induced PDE3A-SLFN12 complex · the same entry in another collection · chain A against A, TM-score 1.00
Q14432 · AlphaFold monomer V2.0 prediction for cgmp-inhibited 3',5'-cyclic phosphodiesterase a… · a predicted model of the same protein · chain A against A, TM-score 0.99
Q8IYM2 · AlphaFold monomer V2.0 prediction for schlafen family member 12 (Q8IYM2) · a predicted model of the same protein · chain B against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14432
Every structure of UniProt Q8IYM2
Elsewhere: RCSB PDB 7EG0 · PDBe 7EG0 · UniProt Q14432 · UniProt Q8IYM2

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