UniProt Q8IYM2
Schlafen family member 12 (Q8IYM2)
Schlafen family member 12 (UniProt Q8IYM2): 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 100 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8IYM2
- Protein
- Schlafen family member 12
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 100 · 7 records with a druggable one
Structures
13 records of Q8IYM2 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EG0 | Cryo-EM structure of anagrelide-induced PDE3A-SLFN12 complex | electron microscopy | B, D | ZN | 18 (best 0.83) |
| 7EG0 | Cryo-EM structure of anagrelide-induced PDE3A-SLFN12 complex | electron microscopy | B, D | ZN | — |
| 7EG1 | Cryo-EM structure of DNMDP-induced PDE3A-SLFN12 complex | electron microscopy | B, D | X5M, ZN | 18 (best 0.83) |
| 7EG1 | Cryo-EM structure of dnmdp-induced PDE3A-SLFN12 complex | electron microscopy | B, D | X5M, ZN | — |
| 7EG4 | Cryo-EM structure of nauclefine-induced PDE3A-SLFN12 complex | electron microscopy | D, B | J36, ZN | 19 (best 0.84) |
| 7EG4 | Cryo-EM structure of nauclefine-induced PDE3A-SLFN12 complex | electron microscopy | D, B | ZN | — |
| 7LRC | Cryo-EM of the SLFN12-PDE3A complex: PDE3A body refinement | electron microscopy | A, D | X5M | 4 (best 0.84) |
| 7LRC | Cryo-EM of the SLFN12-PDE3A complex: PDE3A body refinement | electron microscopy | A, D | X5M | — |
| 7LRD | Cryo-EM of the SLFN12-PDE3A complex: Consensus subset model | electron microscopy | A, C | ZN, X5M | 16 (best 0.84) |
| 7LRD | Cryo-EM of the SLFN12-PDE3A complex: consensus subset model | electron microscopy | A, C | ZN, X5M | — |
| 7LRE | Cryo-EM of the SLFN12-PDE3A complex: SLFN12 body refinement | electron microscopy | A, B | ZN | 16 (best 0.71) |
| 7LRE | Cryo-EM of the SLFN12-PDE3A complex: SLFN12 body refinement | electron microscopy | A, B | ZN | — |
| Q8IYM2 | AlphaFold monomer V2.0 prediction for schlafen family member 12 (Q8IYM2) | predicted | A | — | 9 (best 0.67) |
Ligands
Experiment against prediction
- 7LRE chain A against the predicted model Q8IYM2: TM-score 0.97, RMSD 1.45 Å
- 7LRE chain A against the predicted model Q8IYM2: TM-score 0.97, RMSD 1.45 Å
- 7LRD chain A against the predicted model Q8IYM2: TM-score 0.96, RMSD 1.66 Å
- 7LRD chain A against the predicted model Q8IYM2: TM-score 0.96, RMSD 1.66 Å
- 7EG4 chain D against the predicted model Q8IYM2: TM-score 0.90, RMSD 2.51 Å
- 7EG4 chain D against the predicted model Q8IYM2: TM-score 0.90, RMSD 2.51 Å
- 7EG4 chain B against the predicted model Q8IYM2: TM-score 0.90, RMSD 2.51 Å
- 7EG0 chain B against the predicted model Q8IYM2: TM-score 0.90, RMSD 2.43 Å
- 7EG0 chain B against the predicted model Q8IYM2: TM-score 0.90, RMSD 2.43 Å
- 7EG1 chain B against the predicted model Q8IYM2: TM-score 0.90, RMSD 2.46 Å
Elsewhere
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