X5M · (4~{R})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{H}-pyridazin-6-one

Binding sites

X5M in 8 structures; the first of them:

• 7EG1 · Cryo-EM structure of DNMDP-induced PDE3A-SLFN12 complex · X5M A1201 · binds TYR751, HIS752, THR844, LEU910, ILE951, ASN952, GLY953, PRO954 and 10 more
• 7KWE · Crystal structure of the catalytic domain of human PDE3A bound to DNMDP · X5M A1101 · binds TYR751, LEU910, ILE951, GLY953, PRO954, HIS961, TRP964, THR965 and 5 more
• 7LRC · Cryo-EM of the SLFN12-PDE3A complex: PDE3A body refinement · X5M B2003 · binds TYR751, HIS752, THR844, LEU910, ILE951, GLY953, PRO954, HIS961 and 10 more
• 7LRD · Cryo-EM of the SLFN12-PDE3A complex: Consensus subset model · X5M B2003 · binds LEU554, ILE557, ILE558, TYR751, HIS752, THR844, LEU910, ILE951 and 10 more
• 7EG1 · Cryo-EM structure of dnmdp-induced PDE3A-SLFN12 complex · X5M A1201 · binds TYR751, HIS752, THR844, LEU910, GLY953, PRO954, HIS961, TRP964 and 8 more
• 7KWE · Crystal structure of the catalytic domain of human PDE3A bound to dnmdp · X5M A1101 · binds TYR751, LEU910, GLY953, PRO954, HIS961, TRP964, THR965, ILE968 and 4 more
• 7LRC · Cryo-EM of the SLFN12-PDE3A complex: PDE3A body refinement · X5M B2003 · binds TYR751, HIS752, THR844, LEU910, ILE951, PRO954, HIS961, TRP964 and 6 more
• 7LRD · Cryo-EM of the SLFN12-PDE3A complex: consensus subset model · X5M B2003 · binds ILE557, TYR751, HIS752, THR844, LEU910, ILE951, PRO954, HIS961 and 6 more

Residues it binds most

ILE 20, LEU 20, PHE 20, HIS 20, THR 20, GLN 20, PRO 20, TRP 20, TYR 20, GLY 16 (residue and the binding sites it lines).

Found with

• MG · Magnesium ion
• MN · Manganese (II) ion
• ZN · Zinc ion
• ACT · Acetate ion