UniProt Q13509

Tubulin beta-3 chain (Q13509)

Tubulin beta-3 chain (UniProt Q13509): 31 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 192 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q13509
Protein: Tubulin beta-3 chain
Experimental structures: 31
Predicted models: 1
Ligands: 7
Pockets: 192 · 14 records with a druggable one

Structures

32 records of Q13509 in the MolNFT archive: 31 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5IJ0	Cryo EM density of microtubule assembled from human TUBB3	electron microscopy	B	GTP, GDP	—
5IJ0	Cryo EM density of microtubule assembled from human TUBB3	electron microscopy	B	—	—
5IJ9	Cryo EM density of microtubule assembled from human TUBB3-D417H mutant	electron microscopy	B	GTP, GDP	—
5IJ9	Cryo EM density of microtubule assembled from human TUBB3-D417H mutant	electron microscopy	B	—	—
5JCO	Structure and dynamics of single-isoform recombinant neuronal human tubulin	electron microscopy	K, I, J, C, D, L	G2P, MG, GTP	—
5JCO	Structure and dynamics of single-isoform recombinant neuronal human tubulin	electron microscopy	K, I, J, C, D, L	—	—
6E7B	13-pf 3-start GMPCPP-human alpha1B/beta3 microtubules	electron microscopy	B	MG, G2P, GTP	8 (best 0.83)
6E7B	13-pf 3-start gmpcpp-human ALPHA1B/BETA3 microtubules	electron microscopy	B	MG, G2P, GTP	—
6S8L	Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes	x-ray diffraction	B	GTP, MG, PN6, GDP	9 (best 0.81)
6S8L	Structure, thermodynamics, and kinetics of plinabulin binding to two tubulin isotypes	x-ray diffraction	B	GTP, MG, PN6, GDP	—
6WSL	Cryo-EM structure of VASH1-SVBP bound to microtubules	electron microscopy	B, F	GTP, G2P	14 (best 0.84)
6WSL	Cryo-EM structure of VASH1-svbp bound to microtubules	electron microscopy	B, F	GTP, G2P	—
7LXB	HeLa-tubulin in complex with cryptophycin 52	electron microscopy	B, D, F, H, J, L, N, P	YGY, GDP	16 (best 0.83)
7LXB	Hela-tubulin in complex with cryptophycin 52	electron microscopy	B, D, F, H, J, L, N, P	YGY, GDP	—
7M18	HeLa-tubulin in complex with cryptophycin 1	electron microscopy	B, D, F, H, J, L, N, P	YNP, GDP	13 (best 0.84)
7M18	Hela-tubulin in complex with cryptophycin 1	electron microscopy	B, D, F, H, J, L, N, P	YNP, GDP	—
7M20	18-mer hela-tubulin rings in complex with cryptophycin 1	electron microscopy	B, D, F, H, J, L, N, P, R	GDP, YNP	—
7PJF	Inhibiting parasite proliferation using a rationally designed anti- tubulin agent	x-ray diffraction	B	GTP	—
7SJ7	Undecorated 13pf wildtype microtubule from recombinant human tubulin	electron microscopy	F, D, G, H, I, B	GTP, GDP	16 (best 0.86)
7SJ7	Undecorated 13PF wildtype microtubule from recombinant human tubulin	electron microscopy	F, D, G, H, I, B	GTP, GDP	—
7SJ8	13pf wildtype microtubule from recombinant human tubulin decorated with kinesin	electron microscopy	F, D, G, H, I, B	GTP, GDP	16 (best 0.86)
7SJ8	13PF wildtype microtubule from recombinant human tubulin decorated with kinesin	electron microscopy	F, D, G, H, I, B	GTP, GDP	—
7SJ9	13pf E254A microtubule from recombinant human tubulin decorated with EB3	electron microscopy	B, D, F, G, H, I	GTP, MG	17 (best 0.86)
7SJ9	13PF E254A microtubule from recombinant human tubulin decorated with EB3	electron microscopy	B, D, F, G, H, I	GTP, MG	—
7SJA	Undecorated 13pf E254N microtubule from recombinant human tubulin	electron microscopy	B, D, F, G, H, I	GTP, MG	16 (best 0.84)
7SJA	Undecorated 13PF E254N microtubule from recombinant human tubulin	electron microscopy	B, D, F, G, H, I	GTP, MG	—
7Z6S	MATCAP bound to a human 14 protofilament microtubule	electron microscopy	B, H	GTP, GDP	16 (best 0.84)
7Z6S	Matcap bound to a human 14 protofilament microtubule	electron microscopy	B, H	GTP, GDP	—
8VRJ	Rigid body fitted model for gamma tubulin ring complex capped microtubule	electron microscopy	2, o, p, q, r, s, t, u, v, w, x, y, z	—	14 (best 0.87)
8VRK	Rigid body fitted model for refined density map of gamma tubulin ring complex capped microtubule	electron microscopy	2, o, p, q, r, s, t, u, v, w, x, y, z	—	14 (best 0.87)
8VT7	Structure of the gamma tubulin ring complex nucleated microtubule protofilament.	electron microscopy	F, A	GDP, GTP, MG	17 (best 0.83)
Q13509	AlphaFold monomer V2.0 prediction for tubulin beta-3 chain (Q13509)	predicted	A	—	6 (best 0.59)

Ligands

GTP · Guanosine-5'-triphosphate · in 21 records
GDP · Guanosine-5'-diphosphate · in 16 records
MG · Magnesium ion · in 10 records
G2P · Phosphomethylphosphonic acid guanylate ester · in 5 records
YNP · Cryptophycin 1 · in 3 records
PN6 · (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione · in 2 records
YGY · Cryptophycin 52 · in 2 records

Experiment against prediction

6S8L chain B against the predicted model Q13509: TM-score 0.99, RMSD 0.93 Å
6S8L chain B against the predicted model Q13509: TM-score 0.99, RMSD 0.93 Å
7PJF chain B against the predicted model Q13509: TM-score 0.98, RMSD 1.21 Å
8VT7 chain F against the predicted model Q13509: TM-score 0.98, RMSD 1.22 Å
8VRJ chain 2 against the predicted model Q13509: TM-score 0.97, RMSD 1.24 Å
8VRK chain 2 against the predicted model Q13509: TM-score 0.97, RMSD 1.24 Å
6WSL chain B against the predicted model Q13509: TM-score 0.97, RMSD 1.24 Å
6WSL chain B against the predicted model Q13509: TM-score 0.97, RMSD 1.24 Å
6E7B chain B against the predicted model Q13509: TM-score 0.97, RMSD 1.31 Å
6E7B chain B against the predicted model Q13509: TM-score 0.97, RMSD 1.31 Å

Elsewhere

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