UniProt Q13507
Short transient receptor potential channel 3 (Q13507)
Short transient receptor potential channel 3 (UniProt Q13507): 16 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 152 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q13507
- Protein
- Short transient receptor potential channel 3
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 152 · 8 records with a druggable one
Structures
17 records of Q13507 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZBG | Cryo-EM structure of human TRPC3 at 4.36A resolution | electron microscopy | A, B, C, D | — | 20 (best 0.85) |
| 5ZBG | Cryo-EM structure of human TRPC3 at 4.36A resolution | electron microscopy | A, B, C, D | — | — |
| 6CUD | Structure of the human TRPC3 in a lipid-occupied, closed state | electron microscopy | A, B, C, D | 6OE, FGJ, NAG | 20 (best 0.83) |
| 6CUD | Structure of the human TRPC3 in a lipid-occupied, closed state | electron microscopy | A, B, C, D | 6OE, FGJ, NAG | — |
| 6D7L | Cytoplasmic domain of TRPC3 | electron microscopy | A, B, C, D | — | — |
| 6D7L | Cytoplasmic domain of TRPC3 | electron microscopy | A, B, C, D | — | — |
| 6DJS | Hybrid model of TRPC3 in GDN | electron microscopy | A, B, C, D | — | 20 (best 0.82) |
| 6DJS | Hybrid model of TRPC3 in gdn | electron microscopy | A, B, C, D | — | — |
| 7DXB | Structure of TRPC3 at 2.7 angstrom in high calcium state | electron microscopy | A, B, C, D | POV, Y01, ZN, CA, 98R | 20 (best 0.85) |
| 7DXB | Structure of TRPC3 at 2.7 ångström in high calcium state | electron microscopy | A, B, C, D | POV, Y01, ZN, CA, 98R | — |
| 7DXC | Structure of TRPC3 at 3.06 angstrom in low calcium state | electron microscopy | A, B, C, D | Y01, ZN, 98R, POV | 20 (best 0.84) |
| 7DXC | Structure of TRPC3 at 3.06 ångström in low calcium state | electron microscopy | A, B, C, D | Y01, ZN, 98R, POV | — |
| 7DXD | Structure of TRPC3 at 3.9 angstrom in 1340 nM free calcium state | electron microscopy | A, B, C, D | Y01, ZN, CA | 20 (best 0.86) |
| 7DXD | Structure of TRPC3 at 3.9 ångström in 1340 nm free calcium state | electron microscopy | A, B, C, D | Y01, ZN, CA | — |
| 7DXE | Structure of TRPC3 gain of function mutation R803C at 3.2 angstrom in 1340nM free calcium state | electron microscopy | D, A, B, C | Y01, ZN, POV, 98R | 20 (best 0.85) |
| 7DXE | Structure of TRPC3 gain of function mutation R803C at 3.2 ångström in 1340NM free calcium state | electron microscopy | D, A, B, C | Y01, ZN, POV, 98R | — |
| Q13507 | AlphaFold monomer V2.0 prediction for short transient receptor potential channel 3 (Q13507) | predicted | A | — | 12 (best 0.79) |
Ligands
- Y01 · Cholesterol hemisuccinate · in 8 records
- ZN · Zinc ion · in 8 records
- 98R · [(2S)-2-[(E)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate · in 6 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 6 records
- CA · Calcium ion · in 4 records
- 6OE · (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate · in 2 records
- FGJ · (2R)-3-hydroxypropane-1,2-diyl dihexanoate · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
Experiment against prediction
- 7DXE chain D against the predicted model Q13507: TM-score 0.98, RMSD 1.49 Å
- 7DXE chain D against the predicted model Q13507: TM-score 0.98, RMSD 1.49 Å
- 7DXD chain A against the predicted model Q13507: TM-score 0.96, RMSD 1.89 Å
- 7DXD chain A against the predicted model Q13507: TM-score 0.96, RMSD 1.89 Å
- 7DXC chain A against the predicted model Q13507: TM-score 0.96, RMSD 1.97 Å
- 7DXC chain A against the predicted model Q13507: TM-score 0.96, RMSD 1.97 Å
- 7DXB chain A against the predicted model Q13507: TM-score 0.96, RMSD 2.01 Å
- 7DXB chain A against the predicted model Q13507: TM-score 0.96, RMSD 2.01 Å
- 5ZBG chain A against the predicted model Q13507: TM-score 0.96, RMSD 1.96 Å
- 5ZBG chain A against the predicted model Q13507: TM-score 0.96, RMSD 1.96 Å
Elsewhere
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