MolNFT v1 · #176778 · protein
Structure of TRPC3 at 3.9 ångström in 1340 nm free calcium state
7DXD · Short transient receptor potential channel 3: “Structure of TRPC3 at 3.9 ångström in 1340 nm free calcium state”. Electron microscopy, 3 ligands (Y01, ZN, CA), 20 pockets (best druggability 0.86). MolNFT v1 #176778 on GenesisL1: 3D…
- PDB
- 7DXD
- Type
- protein
- Length
- 2,928 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Short transient receptor potential channel 3
- UniProt
- Q13507
- Ligands
- Y01, ZN, CA
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 68% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Short transient receptor potential channel 3 | protein | 732 | 68% helix, 1% strand | Q13507 |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 4 copies · chains A, C, B, D
- ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
- CA · Calcium ion · metal · 4 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 967 | 0.86 | 0.86 | 85 | empty |
| 2 | 947 | 0.85 | 0.86 | 82 | CA |
| 3 | 765 | 0.85 | 0.88 | 83 | CA |
| 4 | 652 | 0.84 | 0.88 | 52 | CA |
| 5 | 645 | 0.84 | 0.88 | 61 | CA |
Interfaces
6 interfaces between chains.
- A–B · 4925 Ų buried · 29 hydrogen bonds · protein-protein
- C–D · 4921 Ų buried · 29 hydrogen bonds · protein-protein
- B–D · 4920 Ų buried · 29 hydrogen bonds · protein-protein
- A–C · 4905 Ų buried · 29 hydrogen bonds · protein-protein
- A–D · 66 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7DXD · Structure of TRPC3 at 3.9 angstrom in 1340 nM free calcium state · the same entry in another collection · chain A against A, TM-score 1.00
- Q13507 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 3… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13507
- Elsewhere: RCSB PDB 7DXD · PDBe 7DXD · UniProt Q13507
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