MolNFT v1 · #146100 · protein

Cytoplasmic domain of TRPC3

6D7L · Short transient receptor potential channel 3: “Cytoplasmic domain of TRPC3”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #146100 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6D7L
Type: protein
Length: 1,152 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Short transient receptor potential channel 3
UniProt: Q13507
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 1 distinct chain · 60% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Short transient receptor potential channel 3	protein	288	60% helix, 0% strand	Q13507

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1070	0.87	0.88	99	empty
2	786	0.83	0.86	66	empty
3	676	0.82	0.86	57	empty
4	590	0.74	0.81	55	empty
5	65	0.74	0.97	21	empty

Interfaces

6 interfaces between chains.

A–B · 1357 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 1355 Å² buried · 14 hydrogen bonds · protein-protein
C–D · 1355 Å² buried · 14 hydrogen bonds · protein-protein
A–D · 1352 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 44 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6D7L · Cytoplasmic domain of TRPC3 · the same entry in another collection · chain B against B, TM-score 1.00
Q13507 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 3… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13507
Elsewhere: RCSB PDB 6D7L · PDBe 6D7L · UniProt Q13507

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