MolNFT v1 · #146514 · protein

Hybrid model of TRPC3 in gdn

6DJS · Short transient receptor potential channel 3: “Hybrid model of TRPC3 in gdn”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #146514 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DJS
Type: protein
Length: 1,960 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Short transient receptor potential channel 3
UniProt: Q13507
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Short transient receptor potential channel 3	protein	490	70% helix, 0% strand	Q13507

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	966	0.82	0.83	72	empty
2	1040	0.82	0.83	82	empty
3	1060	0.82	0.83	83	empty
4	1112	0.82	0.83	86	empty
5	716	0.79	0.83	80	empty

Interfaces

6 interfaces between chains.

B–C · 1379 Å² buried · 19 hydrogen bonds · protein-protein
A–D · 1371 Å² buried · 20 hydrogen bonds · protein-protein
C–D · 1370 Å² buried · 20 hydrogen bonds · protein-protein
A–B · 1369 Å² buried · 19 hydrogen bonds · protein-protein
B–D · 34 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6DJS · Hybrid model of TRPC3 in GDN · the same entry in another collection · chain A against A, TM-score 1.00
Q13507 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 3… · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13507
Elsewhere: RCSB PDB 6DJS · PDBe 6DJS · UniProt Q13507

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