UniProt Q12791
Calcium-activated potassium channel subunit alpha-1 (Q12791)
Calcium-activated potassium channel subunit alpha-1 (UniProt Q12791): 25 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 276 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q12791
- Protein
- Calcium-activated potassium channel subunit alpha-1
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 276 · 15 records with a druggable one
Structures
26 records of Q12791 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2K44 | Solution structure of a K+-channel voltage-sensor paddle domain | solution nmr | A | — | — |
| 2K44 | Solution structure of a K+-channel voltage-sensor paddle domain | solution nmr | A | — | — |
| 3NAF | Structure of the Intracellular Gating Ring from the Human High-conductance Ca2+ gated K+ Channel… | x-ray diffraction | A | — | — |
| 3NAF | Structure of the intracellular gating ring from the human high- conductance CA2+ gated K+ channel… | x-ray diffraction | A | — | — |
| 6ND0 | human BK channel reconstituted into liposomes | electron microscopy | A, B, C, D | — | 20 (best 0.81) |
| 6ND0 | Human bk channel reconstituted into liposomes | electron microscopy | A, B, C, D | — | — |
| 6V22 | Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex | electron microscopy | A, B, C, D | MG, CA, POV, CLR, K | 20 (best 0.78) |
| 6V22 | Cryo-EM structure of CA2+-bound HSSLO1-BETA4 channel complex | electron microscopy | A, B, C, D | MG, CA, POV, CLR, K | — |
| 6V35 | Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex | electron microscopy | A, B, C, D | PGW, CLR | 20 (best 0.79) |
| 6V35 | Cryo-EM structure of CA2+-free HSSLO1-BETA4 channel complex | electron microscopy | A, B, C, D | PGW, CLR | — |
| 6V38 | Cryo-EM structure of Ca2+-bound hsSlo1 channel | electron microscopy | A, B, C, D | MG, CA, POV, CLR | 20 (best 0.82) |
| 6V38 | Cryo-EM structure of CA2+-bound HSSLO1 channel | electron microscopy | A, B, C, D | MG, CA, POV, CLR | — |
| 6V3G | Cryo-EM structure of Ca2+-free hsSlo1 channel | electron microscopy | B, A, C, D | — | — |
| 6V3G | Cryo-EM structure of CA2+-free HSSLO1 channel | electron microscopy | B, A, C, D | — | — |
| 6V5A | Crystal structure of the human BK channel gating ring L390P mutant | x-ray diffraction | A | CA, SO4 | 9 (best 0.79) |
| 6V5A | Crystal structure of the human bk channel gating ring L390P mutant | x-ray diffraction | A | CA, SO4 | — |
| 8GH9 | Cryo-EM structure of hSlo1 in total membrane vesicles | electron microscopy | A, C, B, D | — | 20 (best 0.80) |
| 8GHF | cryo-EM structure of hSlo1 in plasma membrane vesicles | electron microscopy | A, B, C, D | MG, CA, POV, CLR, NA | 20 (best 0.78) |
| 8GHG | Cryo-EM structure of hSlo1 in digitonin, Ca2+-free and EDTA-free | electron microscopy | A, C, B, D | — | 20 (best 0.82) |
| 8V60 | F315A mutant of human Slo1 in presence of EDTA - resting VSD | electron microscopy | A, B, C, D | K, POV, CLR, AJP | 20 (best 0.81) |
| 8V63 | R207A mutant of human Slo1 in presence of EDTA - activated VSD | electron microscopy | A, B, C, D | K, POV, CLR, AJP | 20 (best 0.79) |
| 8V64 | RCK1-RCK2 double mutant of human Slo1 in presence of EDTA - resting VSD | electron microscopy | A, B, C, D | K, POV, CLR, AJP | 20 (best 0.81) |
| 8VAV | Human Slo1 - human LRRC26 in presence of EDTA - GR masked | electron microscopy | A, B, C, D | POV, K, AJP, CLR | 16 (best 0.70) |
| 8VAZ | Structure of human Slo1 and human LRRC26 in EDTA - LRRD masked | electron microscopy | A, B, C, D | K | 20 (best 0.80) |
| 8Z3S | Activation mechanism and novel binding site of the BKCa channel activator CTIBD | electron microscopy | A, B, C, D | A1L04, Y01, MG, CA | 20 (best 0.80) |
| Q12791 | AlphaFold monomer V2.0 prediction for calcium-activated potassium channel subunit alpha-1 (Q12791) | predicted | A | — | 11 (best 0.80) |
Ligands
- CLR · Cholesterol · in 11 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 9 records
- CA · Calcium ion · in 8 records
- K · Potassium ion · in 7 records
- MG · Magnesium ion · in 6 records
- AJP · Digitonin · in 4 records
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · in 2 records
- SO4 · Sulfate ion · in 2 records
- A1L04 · 4-[4-(4-chlorophenyl)-3-(trifluoromethyl)-1,2-oxazol-5-yl]benzene-1,3-diol · in 1 record
- NA · Sodium ion · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 6V5A chain A against the predicted model Q12791: TM-score 0.99, RMSD 1.16 Å
- 6V5A chain A against the predicted model Q12791: TM-score 0.99, RMSD 1.16 Å
- 6V22 chain A against the predicted model Q12791: TM-score 0.98, RMSD 1.51 Å
- 6V22 chain A against the predicted model Q12791: TM-score 0.98, RMSD 1.51 Å
- 6V38 chain A against the predicted model Q12791: TM-score 0.97, RMSD 1.72 Å
- 6V38 chain A against the predicted model Q12791: TM-score 0.97, RMSD 1.72 Å
- 6ND0 chain D against the predicted model Q12791: TM-score 0.97, RMSD 1.85 Å
- 6ND0 chain C against the predicted model Q12791: TM-score 0.97, RMSD 1.85 Å
- 8GHG chain C against the predicted model Q12791: TM-score 0.97, RMSD 1.92 Å
- 8GHG chain D against the predicted model Q12791: TM-score 0.97, RMSD 1.92 Å
Elsewhere
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