UniProt Q12046
Pre-mRNA-splicing factor CWC2 (Q12046)
Pre-mRNA-splicing factor CWC2 (UniProt Q12046): 35 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12046
- Protein
- Pre-mRNA-splicing factor CWC2
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 18 · 11 records with a druggable one
Structures
36 records of Q12046 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3TP2 | Crystal Structure of the Splicing Factor Cwc2 from yeast | x-ray diffraction | A, B | — | — |
| 3TP2 | Crystal structure of the splicing factor CWC2 from yeast | x-ray diffraction | A, B | — | — |
| 3U1L | Structure of the mRNA splicing complex component Cwc2 | x-ray diffraction | A | — | — |
| 3U1L | Structure of the mRNA splicing complex component CWC2 | x-ray diffraction | A | — | — |
| 3U1M | Structure of the mRNA splicing complex component Cwc2 | x-ray diffraction | A | — | — |
| 3U1M | Structure of the mRNA splicing complex component CWC2 | x-ray diffraction | A | — | — |
| 5GM6 | Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution | electron microscopy | R | ZN | 1 (best 0.87) |
| 5GMK | Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom resolution | electron microscopy | R | ZN | 2 (best 0.87) |
| 5GMK | Cryo-EM structure of the catalytic step I spliceosome (C complex) at 3.4 ångström resolution | electron microscopy | R | — | — |
| 5LJ5 | Overall structure of the yeast spliceosome immediately after branching. | electron microscopy | M | ZN | 2 (best 0.87) |
| 5LJ5 | Overall structure of the yeast spliceosome immediately after branching. | electron microscopy | M | ZN | — |
| 5LQW | yeast activated spliceosome | electron microscopy | F | — | — |
| 5LQW | Yeast activated spliceosome | electron microscopy | F | — | — |
| 5MPS | Structure of a spliceosome remodeled for exon ligation | electron microscopy | M | ZN | 2 (best 0.86) |
| 5MPS | Structure of a spliceosome remodeled for exon ligation | electron microscopy | M | ZN | — |
| 5MQ0 | Structure of a spliceosome remodeled for exon ligation | electron microscopy | M | ZN | 1 (best 0.87) |
| 5MQ0 | Structure of a spliceosome remodeled for exon ligation | electron microscopy | M | ZN | — |
| 5WSG | Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution | electron microscopy | R | ZN | — |
| 5WSG | Cryo-EM structure of the catalytic step II spliceosome (C* complex) at 4.0 ångström resolution | electron microscopy | R | ZN | — |
| 5Y88 | Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5… | electron microscopy | N | ZN | 1 (best 0.86) |
| 5Y88 | Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.CEREVISIAE at 3.5… | electron microscopy | N | ZN | — |
| 5YLZ | Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom | electron microscopy | N | ZN | — |
| 5YLZ | Cryo-EM structure of the post-catalytic spliceosome from saccharomyces cerevisiae at 3.6 ångström | electron microscopy | N | ZN | — |
| 6BK8 | S. cerevisiae spliceosomal post-catalytic P complex | electron microscopy | G | ZN | — |
| 6EXN | Post-catalytic P complex spliceosome with 3' splice site docked | electron microscopy | M | ZN | — |
| 6EXN | Post-catalytic P complex spliceosome with 3' splice site docked | electron microscopy | M | ZN | — |
| 6J6G | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | electron microscopy | R | ZN | 3 (best 0.87) |
| 6J6G | Cryo-EM structure of the yeast B*-A2 complex at an average resolution of 3.2 ångström | electron microscopy | R | ZN | — |
| 6J6H | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | electron microscopy | R | ZN | 2 (best 0.87) |
| 6J6H | Cryo-EM structure of the yeast B*-A1 complex at an average resolution of 3.6 ångström | electron microscopy | R | ZN | — |
| 6J6N | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | electron microscopy | R | ZN | 1 (best 0.87) |
| 6J6N | Cryo-EM structure of the yeast B*-B1 complex at an average resolution of 3.86 ångström | electron microscopy | R | ZN | — |
| 6J6Q | Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom | electron microscopy | R | ZN | 2 (best 0.87) |
| 6J6Q | Cryo-EM structure of the yeast B*-B2 complex at an average resolution of 3.7 ångström | electron microscopy | R | ZN | — |
| 9DTR | Structure of the yeast post-catalytic P complex spliceosome at 2.3 Angstrom resolution | electron microscopy | M | ZN | 1 (best 0.88) |
| Q12046 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor CWC2 (Q12046) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 26 records
Experiment against prediction
- 3TP2 chain B against the predicted model Q12046: TM-score 0.99, RMSD 0.61 Å
- 3TP2 chain B against the predicted model Q12046: TM-score 0.99, RMSD 0.61 Å
- 3U1L chain A against the predicted model Q12046: TM-score 0.98, RMSD 1.03 Å
- 3U1L chain A against the predicted model Q12046: TM-score 0.98, RMSD 1.03 Å
- 3U1M chain A against the predicted model Q12046: TM-score 0.96, RMSD 1.37 Å
- 3U1M chain A against the predicted model Q12046: TM-score 0.96, RMSD 1.37 Å
- 3TP2 chain A against the predicted model Q12046: TM-score 0.95, RMSD 1.61 Å
- 3TP2 chain A against the predicted model Q12046: TM-score 0.95, RMSD 1.61 Å
- 5LJ5 chain M against the predicted model Q12046: TM-score 0.89, RMSD 2.15 Å
- 5LJ5 chain M against the predicted model Q12046: TM-score 0.89, RMSD 2.15 Å
Elsewhere
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