MolNFT v1 · #80178 · protein
Crystal structure of the splicing factor CWC2 from yeast
3TP2 · Pre-mRNA-splicing factor CWC2: “Crystal structure of the splicing factor CWC2 from yeast”. X-ray diffraction, 2 ligands (NA, ZN), 9 pockets (best druggability 0.65). MolNFT v1 #80178 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3TP2
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA-splicing factor CWC2
- UniProt
- Q12046
- Ligands
- NA, ZN
- Pockets
- 9 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-mRNA-splicing factor CWC2 | protein | 225 | 39% helix, 13% strand | Q12046 |
| B | Pre-mRNA-splicing factor CWC2 | protein | 208 | 35% helix, 13% strand | Q12046 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 386 | 0.65 | 0.79 | 54 | empty |
| 2 | 130 | 0.56 | 0.82 | 27 | empty |
| 3 | 248 | 0.51 | 0.75 | 41 | empty |
| 4 | 81 | 0.43 | 0.80 | 17 | empty |
| 5 | 105 | 0.38 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 628 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12046
- Elsewhere: RCSB PDB 3TP2 · PDBe 3TP2 · UniProt Q12046
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