UniProt Q07869
Peroxisome proliferator-activated receptor alpha (Q07869)
Peroxisome proliferator-activated receptor alpha (UniProt Q07869): 111 experimental structures and 1 predicted model on GenesisL1, 26 ligands bound, 78 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q07869
- Protein
- Peroxisome proliferator-activated receptor alpha
- Experimental structures
- 111
- Predicted models
- 1
- Ligands
- 26
- Pockets
- 78 · 30 records with a druggable one
Structures
112 records of Q07869 in the MolNFT archive: 111 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1I7G | Crystal structure of the ligand binding domain from human ppar-alpha in complex with the agonist az… | x-ray diffraction | A | — | — |
| 1I7G | Crystal structure of the ligand binding domain from human ppar-alpha in complex with the agonist az… | x-ray diffraction | A | — | — |
| 1K7L | The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound… | x-ray diffraction | A, C, E, G | — | — |
| 1K7L | The 2.5 ångström resolution crystal structure of the human pparalpha ligand binding domain bound… | x-ray diffraction | A, C, E, G | — | — |
| 1KKQ | Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist… | x-ray diffraction | A, B, C, D | — | — |
| 1KKQ | Crystal structure of the human ppar-alpha ligand-binding domain in complex with an antagonist… | x-ray diffraction | A, B, C, D | — | — |
| 2NPA | the crystal structure of the human PPARaplpha ligand binding domain in complex with a… | x-ray diffraction | A, C | — | — |
| 2NPA | The crystal structure of the human pparaplpha ligand binding domain in complex with a… | x-ray diffraction | A, C | — | — |
| 2P54 | a crystal structure of PPAR alpha bound with SRC1 peptide and GW735 | x-ray diffraction | A | — | — |
| 2P54 | A crystal structure of ppar alpha bound with SRC1 peptide and GW735 | x-ray diffraction | A | — | — |
| 2REW | Crystal Structure of PPARalpha ligand binding domain with BMS-631707 | x-ray diffraction | A | — | — |
| 2REW | Crystal structure of pparalpha ligand binding domain with bms-631707 | x-ray diffraction | A | — | — |
| 2ZNN | Human PPAR alpha ligand binding domain in complex with a synthetic agonist TIPP703 | x-ray diffraction | A | — | — |
| 2ZNN | Human ppar alpha ligand binding domain in complex with a synthetic agonist TIPP703 | x-ray diffraction | A | — | — |
| 3ET1 | Structure of PPARalpha with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid | x-ray diffraction | A, B | — | — |
| 3ET1 | Structure of pparalpha with 3-[5-methoxy-1-(4-methoxy- benzenesulfonyl)-1H-indol-3-yl]-propionic… | x-ray diffraction | A, B | — | — |
| 3FEI | Design and biological evaluation of novel, balanced dual PPARa/g agonists | x-ray diffraction | A | — | — |
| 3FEI | Design and biological evaluation of novel, balanced dual PPARA/G agonists | x-ray diffraction | A | — | — |
| 3G8I | Aleglitazar, a new, potent, and balanced PPAR alpha/gamma agonist for the treatment of type II… | x-ray diffraction | A | — | — |
| 3G8I | Aleglitazar, a new, potent, and balanced ppar ALPHA/GAMMA agonist for the treatment of type II… | x-ray diffraction | A | — | — |
| 3KDT | Crystal structure of peroxisome proliferator-activatedeceptor alpha (PPARalpha) complex with… | x-ray diffraction | A, B | — | — |
| 3KDT | Crystal structure of peroxisome proliferator-activatedeceptor alpha (pparalpha) complex with… | x-ray diffraction | A, B | — | — |
| 3KDU | Crystal structure of peroxisome proliferator-activatedeceptor alpha (PPARalpha) complex with… | x-ray diffraction | A, B | — | — |
| 3KDU | Crystal structure of peroxisome proliferator-activatedeceptor alpha (pparalpha) complex with… | x-ray diffraction | A, B | — | — |
| 3SP6 | Structural basis for iloprost as a dual PPARalpha/delta agonist | x-ray diffraction | A | — | — |
| 3SP6 | Structural basis for iloprost as a dual PPARALPHA/DELTA agonist | x-ray diffraction | A | — | — |
| 3VI8 | Human PPAR alpha ligand binding domain in complex with a synthetic agonist APHM13 | x-ray diffraction | A | — | — |
| 3VI8 | Human ppar alpha ligand binding domain in complex with a synthetic agonist APHM13 | x-ray diffraction | A | — | — |
| 4BCR | Structure of PPARalpha in complex with WY14643 | x-ray diffraction | A, B | — | — |
| 4BCR | Structure of pparalpha in complex with WY14643 | x-ray diffraction | A, B | — | — |
| 4CI4 | Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor alpha agonist | x-ray diffraction | A | — | — |
| 4CI4 | Structural basis for GL479 a dual peroxisome proliferator-activated receptor alpha agonist | x-ray diffraction | A | — | — |
| 5AZT | Ternary complex of hPPARalpha ligand binding domain, 17-oxoDHA and a SRC1 peptide | x-ray diffraction | A, B | — | — |
| 5AZT | Ternary complex of hpparalpha ligand binding domain, 17-oxodha and a SRC1 peptide | x-ray diffraction | A, B | — | — |
| 5HYK | Crystal structure of the complex PPARalpha/AL26-29 | x-ray diffraction | A | 65W | 1 (best 0.84) |
| 5HYK | Crystal structure of the complex PPARALPHA/AL26-29 | x-ray diffraction | A | — | — |
| 6KAX | X-ray structure of human pparalpha ligand binding domain-intrinsic fatty acid (E. COLI origin)… | x-ray diffraction | A | PLM | — |
| 6KAY | X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by soaking | x-ray diffraction | A | 2VN | — |
| 6KAY | X-ray structure of human pparalpha ligand binding domain-GW7647 co- crystals obtained by soaking | x-ray diffraction | A | 2VN | — |
| 6KAZ | X-ray structure of human PPARalpha ligand binding domain-pemafibrate co-crystals obtained by soaking | x-ray diffraction | A | P7F | — |
| 6KAZ | X-ray structure of human pparalpha ligand binding domain-pemafibrate co-crystals obtained by soaking | x-ray diffraction | A | P7F | — |
| 6KB0 | X-ray structure of human PPARalpha ligand binding domain-5,8,11,14-eicosatetraynoic acid (ETYA)… | x-ray diffraction | A | ITY | 2 (best 0.82) |
| 6KB0 | X-ray structure of human pparalpha ligand binding domain-5,8,11,14- eicosatetraynoic acid (etya)… | x-ray diffraction | A | ITY | — |
| 6KB1 | X-ray structure of human PPARalpha ligand binding domain-tetradecylthioacetic acid (TTA)… | x-ray diffraction | A | T4T | — |
| 6KB1 | X-ray structure of human pparalpha ligand binding domain- tetradecylthioacetic acid (tta)… | x-ray diffraction | A | T4T | — |
| 6KB2 | X-ray structure of human PPARalpha ligand binding domain-Wy14643 co-crystals obtained by soaking | x-ray diffraction | A | WY1 | 2 (best 0.83) |
| 6KB2 | X-ray structure of human pparalpha ligand binding domain-WY14643 co- crystals obtained by soaking | x-ray diffraction | A | WY1 | — |
| 6KB3 | X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by… | x-ray diffraction | A | 2VN | — |
| 6KB3 | X-ray structure of human pparalpha ligand binding domain-GW7647 co- crystals obtained by… | x-ray diffraction | A | 2VN | — |
| 6KB4 | X-ray structure of human PPARalpha ligand binding domain-pemafibrate co-crystals obtained by… | x-ray diffraction | A | P7F | 2 (best 0.83) |
| 6KB4 | X-ray structure of human pparalpha ligand binding domain-pemafibrate co-crystals obtained by… | x-ray diffraction | A | P7F | — |
| 6KB5 | X-ray structure of human PPARalpha ligand binding domain-5,8,11,14-eicosatetraynoic Acid (ETYA)… | x-ray diffraction | A | ITY | 2 (best 0.82) |
| 6KB5 | X-ray structure of human pparalpha ligand binding domain-5,8,11,14- eicosatetraynoic acid (etya)… | x-ray diffraction | A | ITY | — |
| 6KB6 | X-ray structure of human pparalpha ligand binding domain- tetradecylthioacetic acid (tta)… | x-ray diffraction | A | T4T | — |
| 6KB7 | X-ray structure of human PPARalpha ligand binding domain-Wy14643 co-crystals obtained by… | x-ray diffraction | A | WY1 | 2 (best 0.83) |
| 6KB7 | X-ray structure of human pparalpha ligand binding domain-WY14643 co- crystals obtained by… | x-ray diffraction | A | WY1 | — |
| 6KB8 | X-ray structure of human pparalpha ligand binding domain-GW7647 co- crystals obtained by… | x-ray diffraction | A | 2VN | — |
| 6KB9 | X-ray structure of human PPARalpha ligand binding domain-pemafibrate co-crystals obtained by… | x-ray diffraction | A | P7F | 2 (best 0.83) |
| 6KB9 | X-ray structure of human pparalpha ligand binding domain-pemafibrate co-crystals obtained by… | x-ray diffraction | A | P7F | — |
| 6KBA | X-ray structure of human pparalpha ligand binding domain-WY14643 co- crystals obtained by… | x-ray diffraction | A | WY1 | — |
52 records more on the page itself.
Ligands
- P7F · (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid · in 8 records
- 2VN · 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl) amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid · in 6 records
- GW9 · 2-chloro-5-nitro-N-phenylbenzamide · in 6 records
- F5A · 2-[4-(4-chlorobenzene-1-carbonyl)phenoxy]-2-methylpropanoic acid · in 5 records
- PLM · Palmitic acid · in 5 records
- WY1 · 2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)acetic acid · in 5 records
- C5F · 2-{4-[(1S)-2,2-dichlorocyclopropyl]phenoxy}-2-methylpropanoic acid · in 4 records
- EWR · (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid · in 4 records
- HW3 · (2S)-2-[[3-[[3-fluoranyl-4-(4-fluoranylphenoxy) phenyl]methylcarbamoyl]-4-methoxy-phenyl]methyl]butanoic acid · in 4 records
- ITY · icosa-5,8,11,14-tetraynoic acid · in 4 records
- E0O · 2-(4-chloranylphenoxy)-2-methyl-propanoic acid · in 3 records
- EPA · 5,8,11,14,17-eicosapentaenoic acid · in 3 records
- T4T · 2-tetradecylsulfanylethanoic acid · in 3 records
- ACD · Arachidonic acid · in 2 records
- HVX · (2S)-2-[[4-butoxy-3-[(pyren-1-ylcarbonylamino) methyl]phenyl]methyl]butanoic acid · in 2 records
- PEM · 2-[P-[2-P-chlorobenzamido)ethyl]phenoxy]-2-methylpropionic acid · in 2 records
- S44 · (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl) amino]methyl}benzyl)butanoic acid · in 2 records
- SAU · 13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium · in 2 records
- STE · Stearic acid · in 2 records
- T02 · 1-(4-chlorophenyl)-6-methyl-3-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid · in 2 records
- T06 · 6-ethyl-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid · in 2 records
- 65W · 2-methyl-2-[4-(naphthalen-1-yl)phenoxy]propanoic acid · in 1 record
- BJB · 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid · in 1 record
- MUO · 2-[2,6-dimethyl-4-[(~{E})-3-(4-methylsulfanylphenyl)-3-oxidanylidene-prop-1-enyl]phenoxy]-2-methyl-propanoic acid · in 1 record
- OLA · Oleic acid · in 1 record
- WUE · (2~{S})-2-(4-naphthalen-1-ylphenoxy)-3-phenyl-propanoic acid · in 1 record
Experiment against prediction
- 3KDU chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.50 Å
- 3KDU chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.50 Å
- 7BQ3 chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.51 Å
- 8HUQ chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.54 Å
- 4CI4 chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.51 Å
- 4CI4 chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.51 Å
- 2REW chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.54 Å
- 2REW chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.54 Å
- 3KDT chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.58 Å
- 3KDT chain A against the predicted model Q07869: TM-score 0.99, RMSD 0.58 Å
Elsewhere
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