MolNFT v1 · #154436 · protein
X-ray structure of human pparalpha ligand binding domain- tetradecylthioacetic acid (tta) co-crystals obtained by soaking
6KB1 · Peroxisome proliferator-activated receptor alpha: “X-ray structure of human pparalpha ligand binding domain- tetradecylthioacetic acid (tta) co-crystals…”. X-ray diffraction, 1 ligand (T4T), 3 pockets (best druggability 0.84).…
- PDB
- 6KB1
- Type
- protein
- Length
- 269 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxisome proliferator-activated receptor alpha
- UniProt
- Q07869
- Ligands
- T4T
- Pockets
- 3 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 68% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peroxisome proliferator-activated receptor alpha | protein | 269 | 68% helix, 5% strand | Q07869 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 407 | 0.84 | 0.91 | 55 | T4T |
| 2 | 51 | 0.33 | 0.77 | 12 | empty |
| 3 | 65 | 0.31 | 0.74 | 12 | empty |
Compared structures
- 6KB1 · X-ray structure of human PPARalpha ligand binding domain-tetradecylthioacetic acid (TTA)… · the same entry in another collection · chain A against A, TM-score 1.00
- Q07869 · AlphaFold monomer V2.0 prediction for peroxisome proliferator- activated receptor alpha… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07869
- Elsewhere: RCSB PDB 6KB1 · PDBe 6KB1 · UniProt Q07869
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